Lineage for Protein: Bruton's tyrosine kinase

  1. Root: SCOPe 2.08
  2. 2739516Class b: All beta proteins [48724] (180 folds)
  3. 2803065Fold b.55: PH domain-like barrel [50728] (3 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 2803066Superfamily b.55.1: PH domain-like [50729] (14 families) (S)
  5. 2803067Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 proteins)
    Pfam PF00169
  6. 2803087Protein Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif

Species:

  • 2803088Human (Homo sapiens) [TaxId:9606] [50739] (10 PDB entries)
    1. Domains for 1b55:
      1. 2803113Domain d1b55a_: 1b55 A: [26963]
        complexed with 4ip, zn
        has additional insertions and/or extensions that are not grouped together
      2. 2803114Domain d1b55b_: 1b55 B: [26964]
        complexed with 4ip, zn
        has additional insertions and/or extensions that are not grouped together
    2. Domains for 1btk:
      1. 2803093Domain d1btka_: 1btk A: [26959]
        complexed with na, zn; mutant
        has additional insertions and/or extensions that are not grouped together
      2. 2803094Domain d1btkb_: 1btk B: [26960]
        complexed with na, zn; mutant
        has additional insertions and/or extensions that are not grouped together
    3. Domains for 1bwn:
      1. 2803103Domain d1bwna_: 1bwn A: [26961]
        complexed with 4ip, zn; mutant
        has additional insertions and/or extensions that are not grouped together
      2. 2803104Domain d1bwnb_: 1bwn B: [26962]
        complexed with 4ip, zn; mutant
        has additional insertions and/or extensions that are not grouped together
    4. Domains for 6tse:
      1. 2803091Domain d6tsea_: 6tse A: [395823]
        automated match to d1btka_
        complexed with 72v, mg, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      2. 2803092Domain d6tseb_: 6tse B: [395787]
        automated match to d1btka_
        complexed with 72v, mg, zn; mutant

        has additional insertions and/or extensions that are not grouped together
    5. Domains for 6tt2:
      1. 2803089Domain d6tt2a_: 6tt2 A: [395839]
        automated match to d1btka_
        complexed with mg, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      2. 2803090Domain d6tt2b_: 6tt2 B: [395913]
        automated match to d1btka_
        complexed with mg, zn; mutant

        has additional insertions and/or extensions that are not grouped together
    6. Domains for 6tuh:
      1. 2803105Domain d6tuha_: 6tuh A: [395890]
        automated match to d1b55a_
        complexed with mg, nxt, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      2. 2803106Domain d6tuhb_: 6tuh B: [395817]
        automated match to d1b55a_
        complexed with mg, nxt, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      3. 2803107Domain d6tuhc_: 6tuh C: [395809]
        automated match to d1b55a_
        complexed with mg, nxt, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      4. 2803108Domain d6tuhd_: 6tuh D: [395815]
        automated match to d1b55a_
        complexed with mg, nxt, zn; mutant

        has additional insertions and/or extensions that are not grouped together
    7. Domains for 6tvn:
      1. 2803109Domain d6tvna_: 6tvn A: [395877]
        automated match to d1b55a_
        complexed with mg, nyq, zn

        has additional insertions and/or extensions that are not grouped together
      2. 2803110Domain d6tvnb_: 6tvn B: [395851]
        automated match to d1b55a_
        complexed with mg, nyq, zn

        has additional insertions and/or extensions that are not grouped together
      3. 2803111Domain d6tvnc_: 6tvn C: [395833]
        automated match to d1b55a_
        complexed with mg, nyq, zn

        has additional insertions and/or extensions that are not grouped together
      4. 2803112Domain d6tvnd_: 6tvn D: [395798]
        automated match to d1b55a_
        complexed with mg, nyq, zn

        has additional insertions and/or extensions that are not grouped together
    8. Domains for 6yyf:
      1. 2803095Domain d6yyfa_: 6yyf A: [404209]
        automated match to d1btka_
        complexed with 3is, mg, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      2. 2803096Domain d6yyfb_: 6yyf B: [404241]
        automated match to d1btka_
        complexed with 3is, mg, zn; mutant

        has additional insertions and/or extensions that are not grouped together
    9. Domains for 6yyg:
      1. 2803097Domain d6yyga_: 6yyg A: [404298]
        automated match to d1b55a_
        complexed with mg, q1b, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      2. 2803098Domain d6yygb_: 6yyg B: [404275]
        automated match to d1b55a_
        complexed with mg, q1b, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      3. 2803099Domain d6yygc_: 6yyg C: [404261]
        automated match to d1b55a_
        complexed with mg, q1b, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      4. 2803100Domain d6yygd_: 6yyg D: [404285]
        automated match to d1b55a_
        complexed with mg, q1b, zn; mutant

        has additional insertions and/or extensions that are not grouped together
    10. Domains for 6yyk:
      1. 2803101Domain d6yyka_: 6yyk A: [404226]
        automated match to d1btka_
        complexed with is7, mg, zn; mutant

        has additional insertions and/or extensions that are not grouped together
      2. 2803102Domain d6yykb_: 6yyk B: [404255]
        automated match to d1btka_
        complexed with is7, mg, zn; mutant

        has additional insertions and/or extensions that are not grouped together

More info for Protein Bruton's tyrosine kinase from b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Protein Bruton's tyrosine kinase from b.55.1.1: Pleckstrin-homology domain (PH domain):