![]() | Class b: All beta proteins [48724] (178 folds) |
![]() | Fold b.55: PH domain-like barrel [50728] (3 superfamilies) barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix |
![]() | Superfamily b.55.1: PH domain-like [50729] (14 families) ![]() |
![]() | Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 proteins) Pfam PF00169 |
![]() | 3-phosphoinositide dependent protein kinase-1 [117246] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [117247] (3 PDB entries) Uniprot O15530 409-550 |
![]() | Alpha-1-syntrophin [141411] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [141412] (1 PDB entry) Uniprot Q61234 2-44,203-264 |
![]() | beta-spectrin [50733] (3 species) |
![]() | Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry) |
![]() | Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry) Uniprot O15020 2219-2324 |
![]() | Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries) |
![]() | Bruton's tyrosine kinase [50738] (1 species) contains Btk zinc-binding motif |
![]() | Species Human (Homo sapiens) [TaxId:9606] [50739] (10 PDB entries) |
![]() | Calcium-dependent activator protein for secretion, CAPS [117252] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [117253] (1 PDB entry) Uniprot Q8NFR0 522-634 |
![]() | Centaurin-delta 1 [141395] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [141396] (1 PDB entry) Uniprot Q8WZ64 483-584 |
![]() | Cytohesin 2 [141401] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [141402] (2 PDB entries) Uniprot P63034 260-378 |
![]() | Cytohesin 3 [141397] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [141398] (1 PDB entry) Uniprot O08967 261-387 |
![]() | Dbl's big sister, Dbs [74989] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [74990] (4 PDB entries) SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence |
![]() | DCC-interacting protein 13-alpha, APPL1 [159211] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [159212] (1 PDB entry) Uniprot Q9UKG1 274-374 |
![]() | Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [117249] (1 PDB entry) Uniprot Q9BZ29 165-301 |
![]() | Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [50750] (2 PDB entries) |
![]() | Dynamin [50736] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [50737] (2 PDB entries) |
![]() | Exocyst complex protein EXO84 [141399] (1 species) |
![]() | Species Norway rat (Rattus norvegicus) [TaxId:10116] [141400] (1 PDB entry) Uniprot O54924 171-283 |
![]() | FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [141416] (1 PDB entry) Uniprot Q5JSP0 605-703 |
![]() | FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [117251] (1 PDB entry) Uniprot Q69ZL1 1303-1389 |
![]() | G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species) |
![]() | Species Cow (Bos taurus) [TaxId:9913] [89354] (6 PDB entries) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry) |
![]() | GEF of intersectin [74991] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [74992] (1 PDB entry) |
![]() | GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [50746] (1 PDB entry) |
![]() | Grp1 [50751] (1 species) ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [50752] (6 PDB entries) |
![]() | KIAA1914 [141407] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [141408] (1 PDB entry) Uniprot Q8N4X5 354-448 |
![]() | Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [110267] (1 PDB entry) Uniprot Q9BZF1 149-265 |
![]() | Phosphoinositide phospholipase C, PLC-gamma-1 [141413] (1 species) contains split PH domain |
![]() | Species Norway rat (Rattus norvegicus) [TaxId:10116] [141414] (1 PDB entry) Uniprot P10686 489-525,870-933 |
![]() | Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [117245] (2 PDB entries) Uniprot Q9H4M7 47-153 |
![]() | Phospholipase C delta-1 [50731] (1 species) |
![]() | Species Norway rat (Rattus norvegicus) [TaxId:10116] [50732] (1 PDB entry) |
![]() | Phospholipase C-beta-2 [159207] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [159208] (2 PDB entries) Uniprot Q00722 11-141 |
![]() | Pleckstrin [50740] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [50741] (6 PDB entries) |
![]() | Pleckstrin-2 [141409] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [141410] (1 PDB entry) Uniprot Q9NYT0 238-353 |
![]() | Protein kinase c, d2 type [141419] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [141420] (1 PDB entry) Uniprot Q9BZL6 398-509 |
![]() | Rac-alpha serine/threonine kinase [89355] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [89356] (4 PDB entries) Uniprot P31749 1-117 |
![]() | Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [110255] (1 PDB entry) Uniprot P31751 1-111 |
![]() | Rac/CDC42 GEF 6, alpha-pix [110262] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [110263] (1 PDB entry) Uniprot Q8K4I3 429-551 |
![]() | Rho GTPase-activating protein 21 [159213] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [159214] (1 PDB entry) Uniprot Q5T5U3 931-1063 |
![]() | Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [117255] (5 PDB entries) Uniprot O15085 714-1081 |
![]() | Rho guanine nucleotide exchange factor 12 [110270] (1 species) |
![]() | Species Human (Homo sapiens), gamma isoform [TaxId:9606] [110271] (2 PDB entries) Uniprot Q9NZN5 766-1138 |
![]() | Rho guanine nucleotide exchange factor 9, Collybistin [159209] (1 species) |
![]() | Species Norway rat (Rattus norvegicus) [TaxId:10116] [159210] (1 PDB entry) Uniprot Q9QX73 300-461 |
![]() | Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [110269] (1 PDB entry) Uniprot P42331 40-144 |
![]() | SET binding factor 1, Sbf1 [110260] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [110261] (1 PDB entry) Uniprot Q8K2Z0 256-367 |
![]() | SH2 and PH domain-containing adapter protein APS [110256] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [110257] (1 PDB entry) Uniprot Q9JID9 178-299 |
![]() | Signal-transducing adaptor protein 1, STAP-1 [141405] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [141406] (1 PDB entry) Uniprot Q9ULZ2 16-151 |
![]() | Son of sevenless-1 (sos-1) [50742] (2 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries) Uniprot Q07889 189-1046 |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry) |
![]() | Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [141404] (1 PDB entry) Uniprot O15268 108-213 |
![]() | Src-associated adaptor protein Skap2 [141417] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [141418] (4 PDB entries) Uniprot Q9Z2K4 105-212! Uniprot Q9Z2K4 109-219! Uniprot Q9Z2K4 14-222 |
![]() | Tapp1 [74993] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [74994] (1 PDB entry) |
![]() | Tapp2 [110258] (1 species) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [110259] (1 PDB entry) Uniprot Q9ERS5 1-113 |
![]() | Triple functional domain protein TRIO [110264] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [110265] (3 PDB entries) Uniprot O75962 1231-1535 |
![]() | UNC-89 [50753] (1 species) |
![]() | Species Nematode (Caenorhabditis elegans) [TaxId:6239] [50754] (1 PDB entry) |
![]() | automated matches [190063] (3 species) not a true protein |
![]() | Species Cow (Bos taurus) [TaxId:9913] [270894] (1 PDB entry) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [187187] (8 PDB entries) |
![]() | Species Norway rat (Rattus norvegicus) [TaxId:10116] [188181] (2 PDB entries) |
Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):