Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOPe 2.06
  2. 2021373Class b: All beta proteins [48724] (177 folds)
  3. 2070980Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 2070981Superfamily b.55.1: PH domain-like [50729] (14 families) (S)
  5. 2070982Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 proteins)
    Pfam PF00169

Proteins:

  1. 20709833-phosphoinositide dependent protein kinase-1 [117246] (1 species)
  2. 2070991Alpha-1-syntrophin [141411] (1 species)
  3. 2070994beta-spectrin [50733] (3 species)
    1. 2070995Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 2070997Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry)
      Uniprot O15020 2219-2324
    3. 2070999Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  4. 2071002Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  5. 2071010Calcium-dependent activator protein for secretion, CAPS [117252] (1 species)
  6. 2071013Centaurin-delta 1 [141395] (1 species)
  7. 2071016Cytohesin 2 [141401] (1 species)
  8. 2071020Cytohesin 3 [141397] (1 species)
  9. 2071023Dbl's big sister, Dbs [74989] (1 species)
    • 2071024Species Mouse (Mus musculus) [TaxId:10090] [74990] (4 PDB entries)
      SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
  10. 2071037DCC-interacting protein 13-alpha, APPL1 [159211] (1 species)
  11. 2071040Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species)
  12. 2071043Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  13. 2071047Dynamin [50736] (1 species)
  14. 2071053Exocyst complex protein EXO84 [141399] (1 species)
  15. 2071056FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415] (1 species)
  16. 2071059FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species)
  17. 2071062G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 2071063Species Cow (Bos taurus) [TaxId:9913] [89354] (6 PDB entries)
    2. 2071073Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  18. 2071075GEF of intersectin [74991] (1 species)
  19. 2071079GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  20. 2071085Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  21. 2071097KIAA1914 [141407] (1 species)
  22. 2071100Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)
  23. 2071103Phosphoinositide phospholipase C, PLC-gamma-1 [141413] (1 species)
    contains split PH domain
  24. 2071106Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species)
  25. 2071110Phospholipase C delta-1 [50731] (1 species)
  26. 2071113Phospholipase C-beta-2 [159207] (1 species)
  27. 2071117Pleckstrin [50740] (1 species)
  28. 2071127Pleckstrin-2 [141409] (1 species)
  29. 2071130Protein kinase c, d2 type [141419] (1 species)
  30. 2071133Rac-alpha serine/threonine kinase [89355] (1 species)
  31. 2071139Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)
  32. 2071142Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)
  33. 2071145Rho GTPase-activating protein 21 [159213] (1 species)
  34. 2071153Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)
  35. 2071165Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  36. 2071172Rho guanine nucleotide exchange factor 9, Collybistin [159209] (1 species)
  37. 2071176Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)
  38. 2071179SET binding factor 1, Sbf1 [110260] (1 species)
  39. 2071182SH2 and PH domain-containing adapter protein APS [110256] (1 species)
  40. 2071185Signal-transducing adaptor protein 1, STAP-1 [141405] (1 species)
  41. 2071188Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 2071189Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries)
      Uniprot Q07889 189-1046
    2. 2071196Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  42. 2071198Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403] (1 species)
  43. 2071204Src-associated adaptor protein Skap2 [141417] (1 species)
  44. 2071215Tapp1 [74993] (1 species)
  45. 2071218Tapp2 [110258] (1 species)
  46. 2071221Triple functional domain protein TRIO [110264] (1 species)
  47. 2071225UNC-89 [50753] (1 species)
  48. 2071228automated matches [190063] (3 species)
    not a true protein
    1. 2071229Species Cow (Bos taurus) [TaxId:9913] [270894] (1 PDB entry)
    2. 2071234Species Human (Homo sapiens) [TaxId:9606] [187187] (8 PDB entries)
    3. 2071253Species Norway rat (Rattus norvegicus) [TaxId:10116] [188181] (2 PDB entries)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):