Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOPe 2.02
  2. 1103260Class b: All beta proteins [48724] (174 folds)
  3. 1132154Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 1132155Superfamily b.55.1: PH domain-like [50729] (14 families) (S)
  5. 1132156Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 proteins)
    Pfam PF00169

Proteins:

  1. 11321573-phosphoinositide dependent protein kinase-1 [117246] (1 species)
  2. 1132165Alpha-1-syntrophin [141411] (1 species)
  3. 1132168beta-spectrin [50733] (3 species)
    1. 1132169Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 1132171Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry)
      Uniprot O15020 2219-2324
    3. 1132173Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  4. 1132176Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  5. 1132184Calcium-dependent activator protein for secretion, CAPS [117252] (1 species)
  6. 1132187Centaurin-delta 1 [141395] (1 species)
  7. 1132190Cytohesin 2 [141401] (1 species)
  8. 1132194Cytohesin 3 [141397] (1 species)
  9. 1132197Dbl's big sister, Dbs [74989] (1 species)
    • 1132198Species Mouse (Mus musculus) [TaxId:10090] [74990] (4 PDB entries)
      SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
  10. 1132211DCC-interacting protein 13-alpha, APPL1 [159211] (1 species)
  11. 1132214Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species)
  12. 1132217Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  13. 1132221Dynamin [50736] (1 species)
  14. 1132227Exocyst complex protein EXO84 [141399] (1 species)
  15. 1132230FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415] (1 species)
  16. 1132233FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species)
  17. 1132236G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 1132237Species Cow (Bos taurus) [TaxId:9913] [89354] (3 PDB entries)
    2. 1132244Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  18. 1132246GEF of intersectin [74991] (1 species)
  19. 1132250GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  20. 1132256Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  21. 1132268KIAA1914 [141407] (1 species)
  22. 1132271Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)
  23. 1132274Phosphoinositide phospholipase C, PLC-gamma-1 [141413] (1 species)
    contains split PH domain
  24. 1132277Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species)
  25. 1132281Phospholipase C delta-1 [50731] (1 species)
  26. 1132284Phospholipase C-beta-2 [159207] (1 species)
  27. 1132288Pleckstrin [50740] (1 species)
  28. 1132298Pleckstrin-2 [141409] (1 species)
  29. 1132301Protein kinase c, d2 type [141419] (1 species)
  30. 1132304Rac-alpha serine/threonine kinase [89355] (1 species)
  31. 1132310Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)
  32. 1132313Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)
  33. 1132316Rho GTPase-activating protein 21 [159213] (1 species)
  34. 1132324Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)
  35. 1132328Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  36. 1132335Rho guanine nucleotide exchange factor 9, Collybistin [159209] (1 species)
  37. 1132338Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)
  38. 1132341SET binding factor 1, Sbf1 [110260] (1 species)
  39. 1132344SH2 and PH domain-containing adapter protein APS [110256] (1 species)
  40. 1132347Signal-transducing adaptor protein 1, STAP-1 [141405] (1 species)
  41. 1132350Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 1132351Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries)
      Uniprot Q07889 189-1046
    2. 1132358Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  42. 1132360Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403] (1 species)
  43. 1132366Src-associated adaptor protein Skap2 [141417] (1 species)
  44. 1132377Tapp1 [74993] (1 species)
  45. 1132380Tapp2 [110258] (1 species)
  46. 1132383Triple functional domain protein TRIO [110264] (1 species)
  47. 1132387UNC-89 [50753] (1 species)
  48. 1132390automated matches [190063] (2 species)
    not a true protein
    1. 1132391Species Human (Homo sapiens) [TaxId:9606] [187187] (6 PDB entries)
    2. 1132408Species Norway rat (Rattus norvegicus) [TaxId:10116] [188181] (2 PDB entries)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):