Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOP 1.75
  2. 781541Class b: All beta proteins [48724] (174 folds)
  3. 805150Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 805151Superfamily b.55.1: PH domain-like [50729] (13 families) (S)
  5. 805152Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (47 proteins)
    Pfam PF00169

Proteins:

  1. 8051533-phosphoinositide dependent protein kinase-1 [117246] (1 species)
  2. 805161Alpha-1-syntrophin [141411] (1 species)
  3. 805164beta-spectrin [50733] (3 species)
    1. 805165Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 805167Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry)
      Uniprot O15020 2219-2324
    3. 805169Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  4. 805172Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  5. 805184Calcium-dependent activator protein for secretion, CAPS [117252] (1 species)
  6. 805187Centaurin-delta 1 [141395] (1 species)
  7. 805190Cytohesin 2 [141401] (1 species)
  8. 805194Cytohesin 3 [141397] (1 species)
  9. 805197Dbl's big sister, Dbs [74989] (1 species)
    • 805198Species Mouse (Mus musculus) [TaxId:10090] [74990] (4 PDB entries)
      SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
  10. 805211DCC-interacting protein 13-alpha, APPL1 [159211] (1 species)
  11. 805214Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species)
  12. 805217Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  13. 805221Dynamin [50736] (1 species)
  14. 805227Exocyst complex protein EXO84 [141399] (1 species)
  15. 805233FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415] (1 species)
  16. 805236FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species)
  17. 805239G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 805240Species Cow (Bos taurus) [TaxId:9913] [89354] (3 PDB entries)
    2. 805247Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  18. 805249GEF of intersectin [74991] (1 species)
  19. 805253GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  20. 805259Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  21. 805271KIAA1914 [141407] (1 species)
  22. 805274Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)
  23. 805277Phosphoinositide phospholipase C, PLC-gamma-1 [141413] (1 species)
    contains split PH domain
  24. 805280Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species)
  25. 805284Phospholipase C delta-1 [50731] (1 species)
  26. 805287Phospholipase C-beta-2 [159207] (1 species)
  27. 805291Pleckstrin [50740] (1 species)
  28. 805302Pleckstrin-2 [141409] (1 species)
  29. 805305Protein kinase c, d2 type [141419] (1 species)
  30. 805308Rac-alpha serine/threonine kinase [89355] (1 species)
  31. 805315Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)
  32. 805318Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)
  33. 805321Rho GTPase-activating protein 21 [159213] (1 species)
  34. 805329Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)
  35. 805333Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  36. 805340Rho guanine nucleotide exchange factor 9, Collybistin [159209] (1 species)
  37. 805343Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)
  38. 805346SET binding factor 1, Sbf1 [110260] (1 species)
  39. 805349SH2 and PH domain-containing adapter protein APS [110256] (1 species)
  40. 805352Signal-transducing adaptor protein 1, STAP-1 [141405] (1 species)
  41. 805355Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 805356Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries)
      Uniprot Q07889 189-1046
    2. 805363Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  42. 805365Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403] (1 species)
  43. 805371Src-associated adaptor protein Skap2 [141417] (1 species)
  44. 805382Tapp1 [74993] (1 species)
  45. 805385Tapp2 [110258] (1 species)
  46. 805388Triple functional domain protein TRIO [110264] (1 species)
  47. 805392UNC-89 [50753] (1 species)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):