SCOP 1.73: Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
   barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix

4. Superfamily b.55.1: PH domain-like [50729] (12 families)

5. Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (43 proteins)
   Pfam PF00169

Proteins:

1. 3-phosphoinositide dependent protein kinase-1 [117246] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117247] (3 PDB entries)

2. Alpha-1-syntrophin [141411] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [141412] (1 PDB entry)

3. beta-spectrin [50733] (3 species)

   1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)

   2. Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry)

   3. Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)

4. Bruton's tyrosine kinase [50738] (1 species)
   contains Btk zinc-binding motif

   • Species Human (Homo sapiens) [TaxId:9606] [50739] (3 PDB entries)

5. Calcium-dependent activator protein for secretion, CAPS [117252] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117253] (1 PDB entry)

6. Centaurin-delta 1 [141395] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141396] (1 PDB entry)

7. Cytohesin 2 [141401] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [141402] (2 PDB entries)

8. Cytohesin 3 [141397] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [141398] (1 PDB entry)

9. Dbl's big sister, Dbs [74989] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [74990] (4 PDB entries)

10. Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [117249] (1 PDB entry)

11. Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50750] (2 PDB entries)

12. Dynamin [50736] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50737] (2 PDB entries)

13. Exocyst complex protein EXO84 [141399] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [141400] (2 PDB entries)

14. FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141416] (1 PDB entry)

15. FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117251] (1 PDB entry)

16. G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [89354] (3 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)

17. GEF of intersectin [74991] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74992] (1 PDB entry)

18. GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [50746] (1 PDB entry)

19. Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog

    • Species Mouse (Mus musculus) [TaxId:10090] [50752] (4 PDB entries)

20. KIAA1914 [141407] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141408] (1 PDB entry)

21. Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110267] (1 PDB entry)

22. Phosphoinositide phospholipase C, PLC-gamma-1 [141413] (1 species)
    contains split PH domain

    • Species Rat (Rattus norvegicus) [TaxId:10116] [141414] (1 PDB entry)

23. Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [117245] (2 PDB entries)

24. Phospholipase C delta-1 [50731] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [50732] (1 PDB entry)

25. Pleckstrin [50740] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50741] (4 PDB entries)

26. Pleckstrin-2 [141409] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141410] (1 PDB entry)

27. Protein kinase c, d2 type [141419] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141420] (1 PDB entry)

28. Rac-alpha serine/threonine kinase [89355] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89356] (5 PDB entries)

29. Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110255] (1 PDB entry)

30. Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [110263] (1 PDB entry)

31. Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [117255] (1 PDB entry)

32. Rho guanine nucleotide exchange factor 12 [110270] (1 species)

    • Species Human (Homo sapiens), gamma isoform [TaxId:9606] [110271] (2 PDB entries)

33. Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110269] (1 PDB entry)

34. SET binding factor 1, Sbf1 [110260] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [110261] (1 PDB entry)

35. SH2 and PH domain-containing adapter protein APS [110256] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [110257] (1 PDB entry)

36. Signal-transducing adaptor protein 1, STAP-1 [141405] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141406] (1 PDB entry)

37. Son of sevenless-1 (sos-1) [50742] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)

38. Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141404] (1 PDB entry)

39. Src-associated adaptor protein Skap2 [141417] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [141418] (4 PDB entries)

40. Tapp1 [74993] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74994] (1 PDB entry)

41. Tapp2 [110258] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [110259] (1 PDB entry)

42. Triple functional domain protein TRIO [110264] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110265] (2 PDB entries)

43. UNC-89 [50753] (1 species)

    • Species Nematode (Caenorhabditis elegans) [TaxId:6239] [50754] (1 PDB entry)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):

• Family b.55.1.1: Pleckstrin-homology domain (PH domain) first appeared (with stable ids) in SCOP 1.55
  
• Family b.55.1.1: Pleckstrin-homology domain (PH domain) appears in SCOP 1.71
  
• Family b.55.1.1: Pleckstrin-homology domain (PH domain) appears in SCOP 1.75
  
• Family b.55.1.1: Pleckstrin-homology domain (PH domain) appears in the current release, SCOPe 2.08