Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOP 1.71
  2. 546417Class b: All beta proteins [48724] (149 folds)
  3. 563841Fold b.55: PH domain-like [50728] (1 superfamily)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 563842Superfamily b.55.1: PH domain-like [50729] (9 families) (S)
  5. 563843Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (30 proteins)
    Pfam 00169

Proteins:

  1. 5638443-phosphoinositide dependent protein kinase-1 [117246] (1 species)
  2. 563852beta-spectrin [50733] (3 species)
    1. 563853Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 563855Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry)
    3. 563857Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  3. 563860Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  4. 563868Calcium-dependent activator protein for secretion, CAPS [117252] (1 species)
  5. 563871Dbl's big sister, Dbs [74989] (1 species)
  6. 563885Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species)
  7. 563888Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  8. 563892Dynamin [50736] (1 species)
  9. 563898FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species)
  10. 563901G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 563902Species Cow (Bos taurus) [TaxId:9913] [89354] (1 PDB entry)
    2. 563904Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  11. 563906GEF of intersectin [74991] (1 species)
  12. 563910GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  13. 563916Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  14. 563924Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)
  15. 563927Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species)
  16. 563931Phospholipase C delta-1 [50731] (1 species)
  17. 563934Pleckstrin, N-terminal domain [50740] (1 species)
  18. 563937Rac-alpha serine/threonine kinase [89355] (1 species)
  19. 563943Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)
  20. 563946Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)
  21. 563949Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)
  22. 563953Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  23. 563960Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)
  24. 563963SET binding factor 1, Sbf1 [110260] (1 species)
  25. 563966SH2 and PH domain-containing adapter protein APS [110256] (1 species)
  26. 563969Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 563970Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries)
    2. 563977Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  27. 563979Tapp1 [74993] (1 species)
  28. 563982Tapp2 [110258] (1 species)
  29. 563985Triple functional domain protein TRIO [110264] (1 species)
  30. 563988UNC-89 [50753] (1 species)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):