Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOP 1.69
  2. 450777Class b: All beta proteins [48724] (144 folds)
  3. 467364Fold b.55: PH domain-like [50728] (1 superfamily)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 467365Superfamily b.55.1: PH domain-like [50729] (9 families) (S)
  5. 467366Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (24 proteins)

Proteins:

  1. 467367beta-spectrin [50733] (2 species)
    1. 467368Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 467370Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  2. 467373Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  3. 467381Dbl's big sister, Dbs [74989] (1 species)
  4. 467395Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  5. 467399Dynamin [50736] (1 species)
  6. 467405G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 467406Species Cow (Bos taurus) [TaxId:9913] [89354] (1 PDB entry)
    2. 467408Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  7. 467410GEF of intersectin [74991] (1 species)
  8. 467414GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  9. 467420Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  10. 467428Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)
  11. 467431Phospholipase C delta-1 [50731] (1 species)
  12. 467434Pleckstrin, N-terminal domain [50740] (1 species)
  13. 467437Rac-alpha serine/threonine kinase [89355] (1 species)
  14. 467443Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)
  15. 467446Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)
  16. 467449Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  17. 467456Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)
  18. 467459SET binding factor 1, Sbf1 [110260] (1 species)
  19. 467462SH2 and PH domain-containing adapter protein APS [110256] (1 species)
  20. 467465Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 467466Species Human (Homo sapiens) [TaxId:9606] [50744] (2 PDB entries)
    2. 467469Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  21. 467471Tapp1 [74993] (1 species)
  22. 467474Tapp2 [110258] (1 species)
  23. 467477Triple functional domain protein TRIO [110264] (1 species)
  24. 467480UNC-89 [50753] (1 species)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):