Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOP 1.67
  2. 362614Class b: All beta proteins [48724] (141 folds)
  3. 378166Fold b.55: PH domain-like [50728] (1 superfamily)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 378167Superfamily b.55.1: PH domain-like [50729] (8 families) (S)
  5. 378168Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (15 proteins)

Proteins:

  1. 378169beta-spectrin [50733] (2 species)
    1. 378170Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 378172Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  2. 378175Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  3. 378183Dbl's big sister, Dbs [74989] (1 species)
  4. 378193Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  5. 378197Dynamin [50736] (1 species)
  6. 378203G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 378204Species Cow (Bos taurus) [TaxId:9913] [89354] (1 PDB entry)
    2. 378206Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  7. 378208GEF of intersectin [74991] (1 species)
  8. 378212GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  9. 378218Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  10. 378226Phospholipase C delta-1 [50731] (1 species)
  11. 378229Pleckstrin, N-terminal domain [50740] (1 species)
  12. 378232Rac-alpha serine/threonine kinase [89355] (1 species)
  13. 378235Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 378236Species Human (Homo sapiens) [TaxId:9606] [50744] (2 PDB entries)
    2. 378239Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  14. 378241Tapp1 [74993] (1 species)
  15. 378244UNC-89 [50753] (1 species)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):