SCOP 1.67: Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

1. Root: SCOP 1.67

2. Class b: All beta proteins [48724] (141 folds)

3. Fold b.55: PH domain-like [50728] (1 superfamily)
   barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix

4. Superfamily b.55.1: PH domain-like [50729] (8 families)

5. Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (15 proteins)

Proteins:

1. beta-spectrin [50733] (2 species)

   1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)

   2. Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)

2. Bruton's tyrosine kinase [50738] (1 species)
   contains Btk zinc-binding motif

   • Species Human (Homo sapiens) [TaxId:9606] [50739] (3 PDB entries)

3. Dbl's big sister, Dbs [74989] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [74990] (3 PDB entries)

4. Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50750] (2 PDB entries)

5. Dynamin [50736] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50737] (2 PDB entries)

6. G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [89354] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)

7. GEF of intersectin [74991] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [74992] (1 PDB entry)

8. GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [50746] (1 PDB entry)

9. Grp1 [50751] (1 species)
   ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog

   • Species Mouse (Mus musculus) [TaxId:10090] [50752] (4 PDB entries)

10. Phospholipase C delta-1 [50731] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [50732] (1 PDB entry)

11. Pleckstrin, N-terminal domain [50740] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50741] (1 PDB entry)

12. Rac-alpha serine/threonine kinase [89355] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89356] (1 PDB entry)

13. Son of sevenless-1 (sos-1) [50742] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [50744] (2 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)

14. Tapp1 [74993] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74994] (1 PDB entry)

15. UNC-89 [50753] (1 species)

    • Species Nematode (Caenorhabditis elegans) [TaxId:6239] [50754] (1 PDB entry)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):

• Family b.55.1.1: Pleckstrin-homology domain (PH domain) first appeared (with stable ids) in SCOP 1.55
  
• Family b.55.1.1: Pleckstrin-homology domain (PH domain) appears in SCOP 1.65
  
• Family b.55.1.1: Pleckstrin-homology domain (PH domain) appears in SCOP 1.69
  
• Family b.55.1.1: Pleckstrin-homology domain (PH domain) appears in the current release, SCOPe 2.08