SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Superfamily b.55.1: PH domain-like

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2061576Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 2061577Superfamily b.55.1: PH domain-like [50729] (14 families) (S)

Families:

  1. 2061578b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 protein domains)
    Pfam PF00169
  2. 2061849b.55.1.2: Phosphotyrosine-binding domain (PTB) [50755] (13 protein domains)
    Pfam PF00640
  3. 2061928b.55.1.3: Ran-binding domain [50764] (5 protein domains)
  4. 2061957b.55.1.4: Enabled/VASP homology 1 domain (EVH1 domain) [50767] (7 protein domains)
  5. 2061996b.55.1.5: Third domain of FERM [50776] (8 protein domains)
  6. 2062067b.55.1.6: PreBEACH PH-like domain [82146] (2 protein domains)
  7. 2062078b.55.1.7: Dcp1 [101836] (1 protein)
    close structural similarity to EVH1 domain
  8. 2062083b.55.1.8: GRAM domain [101839] (1 protein)
  9. 2062091b.55.1.9: TFIIH domain [110272] (2 protein domains)
  10. 2062109b.55.1.10: SSRP1-like [141436] (2 protein domains)
    Pfam PF03531; Structure-specific recognition protein family; duplication: comprises tandem repeat of two domains of this fold
  11. 2062122b.55.1.11: Necap1 N-terminal domain-like [141439] (1 protein)
    Pfam PF07933; DUF1681
  12. 2062126b.55.1.12: VPS36 N-terminal domain-like [141442] (1 protein)
    PfamB PB030385
  13. 2062135b.55.1.13: BPHL domain [159216] (3 protein domains)
    Pfam PF08000; DUF1696, bacterial proteins with PH-like domain
  14. 2062158b.55.1.0: automated matches [191311] (1 protein)
    not a true family

More info for Superfamily b.55.1: PH domain-like

Timeline for Superfamily b.55.1: PH domain-like: