SCOP 1.71: Protein: Plasmepsin (a hemoglobin-degrading enzyme)

Lineage for Protein: Plasmepsin (a hemoglobin-degrading enzyme)

Root: SCOP 1.71
Class b: All beta proteins [48724] (149 folds)
Fold b.50: Acid proteases [50629] (1 superfamily)
barrel, closed; n=6, S=10, complex topology
Superfamily b.50.1: Acid proteases [50630] (2 families)
Family b.50.1.2: Pepsin-like [50646] (10 proteins)
duplication: consists of two similar barrel domains
N-terminal: barrel, partly opened; n*=6, S*=10
Protein Plasmepsin (a hemoglobin-degrading enzyme) [50673] (3 species)

Species:

Plasmodium falciparum, plasmepsin II [TaxId:5833] [50674] (8 PDB entries)
1. Domain for 1lee:
  - Domain d1leea_: 1lee A: [77908]
    complexed with r36
2. Domain for 1lf2:
  - Domain d1lf2a_: 1lf2 A: [77914]
    complexed with r37
3. Domain for 1lf3:
  - Domain d1lf3a_: 1lf3 A: [77915]
    complexed with eh5
4. Domain for 1lf4:
  - Domain d1lf4a_: 1lf4 A: [77916]
5. Domains for 1m43:
  1. Domain d1m43a_: 1m43 A: [74438]
  2. Domain d1m43b_: 1m43 B: [74439]
    complexed with ihn; mutant
6. Domains for 1me6:
  1. Domain d1me6a_: 1me6 A: [91247]
  2. Domain d1me6b_: 1me6 B: [91248]
    complexed with ivs
7. Domains for 1pfz:
  1. Domain d1pfza_: 1pfz A: [26881]
  2. Domain d1pfzb_: 1pfz B: [26882]
  3. Domain d1pfzc_: 1pfz C: [26883]
  4. Domain d1pfzd_: 1pfz D: [26884]
    complexed with gol; mutant
8. Domains for 1sme:
  1. Domain d1smea_: 1sme A: [26885]
  2. Domain d1smeb_: 1sme B: [26886]
    complexed with ihn
Plasmodium falciparum, plasmepsin IV [TaxId:5833] [74986] (1 PDB entry)
- Domains for 1ls5:
  1. Domain d1ls5a_: 1ls5 A: [74240]
  2. Domain d1ls5b_: 1ls5 B: [74241]
    complexed with ihn
Plasmodium vivax [TaxId:5855] [50675] (2 PDB entries)
1. Domains for 1miq:
  1. Domain d1miqa_: 1miq A: [79151]
  2. Domain d1miqb_: 1miq B: [79152]
    proenzyme
2. Domains for 1qs8:
  1. Domain d1qs8a_: 1qs8 A: [26887]
  2. Domain d1qs8b_: 1qs8 B: [26888]
    complexed with act, iva, sta

More info for Protein Plasmepsin (a hemoglobin-degrading enzyme) from b.50.1.2: Pepsin-like

Timeline for Protein Plasmepsin (a hemoglobin-degrading enzyme) from b.50.1.2: Pepsin-like:

Protein Plasmepsin (a hemoglobin-degrading enzyme) from b.50.1.2: Pepsin-like first appeared (with stable ids) in SCOP 1.55, called Protein Plasmepsin ii (a hemoglobin-degrading enzyme) from b.50.1.2: Pepsin-like
Protein Plasmepsin (a hemoglobin-degrading enzyme) from b.50.1.2: Pepsin-like appears in SCOP 1.69
Protein Plasmepsin (a hemoglobin-degrading enzyme) from b.50.1.2: Pepsin-like appears in SCOP 1.73
Protein Plasmepsin (a hemoglobin-degrading enzyme) from b.50.1.2: Pepsin-like appears in the current release, SCOPe 2.08