Lineage for Family b.50.1.2: Pepsin-like

  1. Root: SCOPe 2.04
  2. 1510239Class b: All beta proteins [48724] (176 folds)
  3. 1548217Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 1548218Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 1549490Family b.50.1.2: Pepsin-like [50646] (11 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10

Proteins:

  1. 1549491Acid protease [50649] (9 species)
    1. 1549492Species Baker's yeast (Saccharomyces cerevisiae), proteinase A [TaxId:4932] [50654] (11 PDB entries)
      synonym: saccharopepsin
    2. 1549505Species Bread mold (Rhizopus chinensis) [TaxId:4843] [50651] (8 PDB entries)
      Uniprot P06026 69-393
    3. 1549514Species Fungus (Aspergillus oryzae) [TaxId:5062] [89352] (2 PDB entries)
    4. 1549517Species Fungus (Aspergillus phoenicis), aspergillopepsin [TaxId:5063] [63794] (1 PDB entry)
    5. 1549520Species Fungus (Penicillium janthinellum), penicillopepsin [TaxId:5079] [50650] (14 PDB entries)
    6. 1549535Species Irpex lacteus (Polyporus tulipiferae), Polyporopepsin [TaxId:5319] [110246] (1 PDB entry)
      Uniprot P17576 1-329
    7. 1549537Species Rhizomucor miehei [TaxId:4839] [50652] (2 PDB entries)
    8. 1549540Species Yeast (Candida albicans) [TaxId:5476] [50653] (4 PDB entries)
    9. 1549545Species Yeast (Candida tropicalis) [TaxId:5482] [63795] (1 PDB entry)
  2. 1549547beta-secretase (memapsin) [50671] (1 species)
  3. 1549928Cathepsin D [50665] (1 species)
  4. 1549938Chymosin (synonym: renin) [50667] (3 species)
    1. 1549939Species Cow (Bos taurus) [TaxId:9913] [50668] (6 PDB entries)
    2. 1549946Species Human (Homo sapiens) [TaxId:9606] [50669] (62 PDB entries)
    3. 1550068Species Mouse (Mus musculus) [TaxId:10090] [50670] (1 PDB entry)
  5. 1550073Endothiapepsin [50647] (1 species)
  6. 1550122Pepsin [50663] (1 species)
  7. 1550125Pepsin(ogen) [50658] (4 species)
    1. 1550126Species Atlantic cod (Gadus morhua) [TaxId:8049] [50662] (1 PDB entry)
    2. 1550128Species Human (Homo sapiens), isoform 3A [TaxId:9606] [50660] (5 PDB entries)
    3. 1550134Species Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId:9606] [50661] (2 PDB entries)
    4. 1550138Species Pig (Sus scrofa) [TaxId:9823] [50659] (8 PDB entries)
  8. 1550148Plant acid proteinase, phytepsin [50655] (2 species)
    1. 1550149Species Barley (Hordeum vulgare) [TaxId:4513] [50657] (1 PDB entry)
    2. 1550153Species Cynara cardunculus [TaxId:4265] [50656] (1 PDB entry)
  9. 1550156Plasmepsin (a hemoglobin-degrading enzyme) [50673] (3 species)
    1. 1550157Species Plasmodium falciparum, plasmepsin II [TaxId:5833] [50674] (19 PDB entries)
    2. 1550195Species Plasmodium falciparum, plasmepsin IV [TaxId:5833] [74986] (1 PDB entry)
    3. 1550198Species Plasmodium vivax [TaxId:5855] [50675] (2 PDB entries)
  10. 1550203Xylanase inhibitor TAXI-I [110247] (1 species)
    pepsin-like protein that probably lost the protease activity
  11. 1550211automated matches [190156] (4 species)
    not a true protein
    1. 1550212Species Camel (Camelus dromedarius) [TaxId:9838] [197076] (1 PDB entry)
    2. 1550214Species Cryphonectria parasitica [TaxId:5116] [187236] (21 PDB entries)
    3. 1550236Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)
    4. 1550287Species Yeast (Candida albicans) [TaxId:5476] [188488] (4 PDB entries)

More info for Family b.50.1.2: Pepsin-like

Timeline for Family b.50.1.2: Pepsin-like: