SCOP 1.75: Family b.50.1.2: Pepsin-like

Lineage for Family b.50.1.2: Pepsin-like

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (3 families)

5. Family b.50.1.2: Pepsin-like [50646] (10 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

Proteins:

1. Acid protease [50649] (9 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae), proteinase A [TaxId:4932] [50654] (11 PDB entries)
      synonym: saccharopepsin

   2. Species Bread mold (Rhizopus chinensis) [TaxId:4843] [50651] (8 PDB entries)
      Uniprot P06026 69-393

   3. Species Fungus (Aspergillus oryzae) [TaxId:5062] [89352] (2 PDB entries)

   4. Species Fungus (Aspergillus phoenicis), aspergillopepsin [TaxId:5063] [63794] (1 PDB entry)

   5. Species Fungus (Penicillium janthinellum), penicillopepsin [TaxId:5079] [50650] (14 PDB entries)

   6. Species Irpex lacteus (Polyporus tulipiferae), Polyporopepsin [TaxId:5319] [110246] (1 PDB entry)
      Uniprot P17576 1-329

   7. Species Rhizomucor miehei [TaxId:4839] [50652] (2 PDB entries)

   8. Species Yeast (Candida albicans) [TaxId:5476] [50653] (2 PDB entries)

   9. Species Yeast (Candida tropicalis) [TaxId:5482] [63795] (1 PDB entry)

2. beta-secretase (memapsin) [50671] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50672] (51 PDB entries)
     Uniprot P56817 58-446
     Uniprot P56817 60-447
     Uniprot P56817 58-446 ! Uniprot P56817 60-447

3. Cathepsin D [50665] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50666] (3 PDB entries)

4. Chymosin (synonym: renin) [50667] (3 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [50668] (4 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [50669] (6 PDB entries)

   3. Species Mouse (Mus musculus) [TaxId:10090] [50670] (1 PDB entry)

5. Endothiapepsin [50647] (1 species)

   • Species Chestnut blight fungus (Endothia parasitica) [TaxId:5116] [50648] (36 PDB entries)

6. Pepsin [50663] (1 species)

   • Species Mucor pusillus [TaxId:4840] [50664] (1 PDB entry)

7. Pepsin(ogen) [50658] (4 species)

   1. Species Atlantic cod (Gadus morhua) [TaxId:8049] [50662] (1 PDB entry)

   2. Species Human (Homo sapiens), isoform 3A [TaxId:9606] [50660] (4 PDB entries)

   3. Species Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId:9606] [50661] (2 PDB entries)

   4. Species Pig (Sus scrofa) [TaxId:9823] [50659] (8 PDB entries)

8. Plant acid proteinase, phytepsin [50655] (2 species)

   1. Species Barley (Hordeum vulgare) [TaxId:4513] [50657] (1 PDB entry)

   2. Species Cynara cardunculus [TaxId:4265] [50656] (1 PDB entry)

9. Plasmepsin (a hemoglobin-degrading enzyme) [50673] (3 species)

   1. Species Plasmodium falciparum, plasmepsin II [TaxId:5833] [50674] (17 PDB entries)

   2. Species Plasmodium falciparum, plasmepsin IV [TaxId:5833] [74986] (1 PDB entry)

   3. Species Plasmodium vivax [TaxId:5855] [50675] (2 PDB entries)

10. Xylanase inhibitor TAXI-I [110247] (1 species)
    pepsin-like protein that probably lost the protease activity

    • Species Wheat (Triticum aestivum) [TaxId:4565] [110248] (3 PDB entries)
      Uniprot Q8H0K8 22-402

More info for Family b.50.1.2: Pepsin-like

Timeline for Family b.50.1.2: Pepsin-like:

• Family b.50.1.2: Pepsin-like first appeared (with stable ids) in SCOP 1.55
  
• Family b.50.1.2: Pepsin-like appears in SCOP 1.73
  
• Family b.50.1.2: Pepsin-like appears in SCOPe 2.01
  
• Family b.50.1.2: Pepsin-like appears in the current release, SCOPe 2.08