Lineage for Family b.50.1.2: Pepsin-like

  1. Root: SCOP 1.71
  2. 546417Class b: All beta proteins [48724] (149 folds)
  3. 562942Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 562943Superfamily b.50.1: Acid proteases [50630] (2 families) (S)
  5. 563392Family b.50.1.2: Pepsin-like [50646] (10 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10

Proteins:

  1. 563393Acid protease [50649] (9 species)
    1. 563394Species Baker's yeast (Saccharomyces cerevisiae), proteinase A [TaxId:4932] [50654] (11 PDB entries)
      synonym: saccharopepsin
    2. 563407Species Bread mold (Rhizopus chinensis) [TaxId:4843] [50651] (8 PDB entries)
    3. 563416Species Fungus (Aspergillus oryzae) [TaxId:5062] [89352] (2 PDB entries)
    4. 563419Species Fungus (Aspergillus phoenicis), aspergillopepsin [TaxId:5063] [63794] (1 PDB entry)
    5. 563422Species Fungus (Penicillium janthinellum), penicillopepsin [TaxId:5079] [50650] (14 PDB entries)
    6. 563437Species Irpex lacteus (Polyporus tulipiferae), Polyporopepsin [TaxId:5319] [110246] (1 PDB entry)
    7. 563439Species Rhizomucor miehei [TaxId:4839] [50652] (2 PDB entries)
    8. 563442Species Yeast (Candida albicans) [TaxId:5476] [50653] (2 PDB entries)
    9. 563445Species Yeast (Candida tropicalis) [TaxId:5482] [63795] (1 PDB entry)
  2. 563447beta-secretase (memapsin) [50671] (1 species)
  3. 563461Cathepsin D [50665] (1 species)
  4. 563471Chymosin (synonym: renin) [50667] (3 species)
    1. 563472Species Cow (Bos taurus) [TaxId:9913] [50668] (4 PDB entries)
    2. 563477Species Human (Homo sapiens) [TaxId:9606] [50669] (9 PDB entries)
    3. 563491Species Mouse (Mus musculus) [TaxId:10090] [50670] (1 PDB entry)
  5. 563493Endothiapepsin [50647] (1 species)
  6. 563530Pepsin [50663] (1 species)
  7. 563533Pepsin(ogen) [50658] (4 species)
    1. 563534Species Atlantic cod (Gadus morhua) [TaxId:8049] [50662] (1 PDB entry)
    2. 563536Species Human (Homo sapiens), 3A [TaxId:9606] [50660] (4 PDB entries)
    3. 563541Species Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId:9606] [50661] (2 PDB entries)
    4. 563545Species Pig (Sus scrofa) [TaxId:9823] [50659] (7 PDB entries)
  8. 563554Plant acid proteinase, phytepsin [50655] (2 species)
    1. 563555Species Barley (Hordeum vulgare) [TaxId:4513] [50657] (1 PDB entry)
    2. 563559Species Cynara cardunculus [TaxId:4265] [50656] (1 PDB entry)
  9. 563562Plasmepsin (a hemoglobin-degrading enzyme) [50673] (3 species)
    1. 563563Species Plasmodium falciparum, plasmepsin II [TaxId:5833] [50674] (8 PDB entries)
    2. 563578Species Plasmodium falciparum, plasmepsin IV [TaxId:5833] [74986] (1 PDB entry)
    3. 563581Species Plasmodium vivax [TaxId:5855] [50675] (2 PDB entries)
  10. 563586Xylanase inhibitor TAXI-I [110247] (1 species)
    pepsin-like protein that probably lost the protease activity

More info for Family b.50.1.2: Pepsin-like

Timeline for Family b.50.1.2: Pepsin-like: