Lineage for Family b.50.1.2: Pepsin-like

  1. Root: SCOP 1.63
  2. 218896Class b: All beta proteins [48724] (119 folds)
  3. 231370Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 231371Superfamily b.50.1: Acid proteases [50630] (2 families) (S)
  5. 231766Family b.50.1.2: Pepsin-like [50646] (9 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10

Proteins:

  1. 231767Acid protease [50649] (7 species)
    1. 231768Species Baker's yeast (Saccharomyces cerevisiae), proteinase A [TaxId:4932] [50654] (11 PDB entries)
      synonym: saccharopepsin
    2. 231781Species Bread mold (Rhizopus chinensis) [TaxId:4843] [50651] (5 PDB entries)
    3. 231787Species Fungus (Aspergillus phoenicis), aspergillopepsin [TaxId:5063] [63794] (1 PDB entry)
    4. 231790Species Fungus (Penicillium janthinellum), penicillopepsin [TaxId:5079] [50650] (14 PDB entries)
    5. 231805Species Rhizomucor miehei [TaxId:4839] [50652] (2 PDB entries)
    6. 231808Species Yeast (Candida albicans) [TaxId:5476] [50653] (2 PDB entries)
    7. 231811Species Yeast (Candida tropicalis) [TaxId:5482] [63795] (1 PDB entry)
  2. 231813beta-secretase (memapsin) [50671] (1 species)
  3. 231819Cathepsin D [50665] (1 species)
  4. 231829Chymosin (synonim: renin) [50667] (3 species)
    1. 231830Species Cow (Bos taurus) [TaxId:9913] [50668] (4 PDB entries)
    2. 231835Species Human (Homo sapiens) [TaxId:9606] [50669] (6 PDB entries)
    3. 231845Species Mouse (Mus musculus) [TaxId:10090] [50670] (1 PDB entry)
  5. 231847Endothiapepsin [50647] (1 species)
  6. 231881Pepsin [50663] (1 species)
  7. 231884Pepsin(ogen) [50658] (4 species)
    1. 231885Species Atlantic cod (Gadus morhua) [TaxId:8049] [50662] (1 PDB entry)
    2. 231887Species Human (Homo sapiens), 3A [TaxId:9606] [50660] (4 PDB entries)
    3. 231892Species Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId:9606] [50661] (2 PDB entries)
    4. 231896Species Pig (Sus scrofa) [TaxId:9823] [50659] (7 PDB entries)
  8. 231905Plant acid proteinase, phytepsin [50655] (2 species)
    1. 231906Species Barley (Hordeum vulgare) [TaxId:4513] [50657] (1 PDB entry)
    2. 231910Species Cynara cardunculus [TaxId:4265] [50656] (1 PDB entry)
  9. 231913Plasmepsin (a hemoglobin-degrading enzyme) [50673] (3 species)
    1. 231914Species Plasmodium falciparum, plasmepsin II [TaxId:5833] [50674] (7 PDB entries)
    2. 231927Species Plasmodium falciparum, plasmepsin IV [TaxId:5833] [74986] (1 PDB entry)
    3. 231930Species Plasmodium vivax [TaxId:5855] [50675] (2 PDB entries)

More info for Family b.50.1.2: Pepsin-like

Timeline for Family b.50.1.2: Pepsin-like: