SCOPe 2.02: Family b.50.1.1: Retroviral protease (retropepsin)

Lineage for Family b.50.1.1: Retroviral protease (retropepsin)

1. Root: SCOPe 2.02

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

Proteins:

1. EIAV protease [50644] (1 species)

   • Species Equine infectious anemia virus [TaxId:11665] [50645] (2 PDB entries)

2. Feline immunodeficiency virus (FIV) protease [50638] (1 species)

   • Species Feline immunodeficiency virus [TaxId:11673] [50639] (7 PDB entries)

3. Human immunodeficiency virus type 1 protease [50632] (7 species)

   1. Species Hiv-1 m:b_arv2/sf2 [TaxId:11685] [187932] (17 PDB entries)

   2. Species Human immunodeficiency virus 2 [TaxId:11709] [195770] (1 PDB entry)

   3. Species Human immunodeficiency virus type 1 (bh5 isolate) [TaxId:11682] [186950] (13 PDB entries)

   4. Species Human immunodeficiency virus type 1 (bru isolate) [TaxId:11686] [194276] (1 PDB entry)

   5. Species Human immunodeficiency virus type 1 (isolate z2/cdc-z34 group m subtype d) [TaxId:11683] [189173] (1 PDB entry)

   6. Species Human immunodeficiency virus type 1 lw12.3 isolate [TaxId:82834] [189723] (2 PDB entries)

   7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (413 PDB entries)
      Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

4. Human immunodeficiency virus type 2 (HIV-2) protease [50634] (2 species)

   1. Species Human immunodeficiency virus type 2 (isolate rod) [TaxId:11720] [187235] (3 PDB entries)

   2. Species Human immunodeficiency virus type 2 [TaxId:11709] [50635] (15 PDB entries)

5. Mason-Pfizer monkey virus protease [82131] (1 species)

   • Species Simian retrovirus 1, SRV-1 [TaxId:11942] [82132] (1 PDB entry)

6. Myeloblastosis-associated viral protease [50642] (1 species)

   • Species Avian myeloblastosis associated virus [TaxId:11960] [50643] (1 PDB entry)

7. Rous sarcoma virus protease [50640] (1 species)

   • Species Rous sarcoma virus, strain pr-C [TaxId:11886] [50641] (2 PDB entries)

8. Simian immunodeficiency virus (SIV) protease [50636] (1 species)

   • Species Simian immunodeficiency virus, different strains [TaxId:11723] [50637] (7 PDB entries)

9. automated matches [190433] (11 species)
   not a true protein

   1. Species Feline immunodeficiency virus (isolate petaluma) [TaxId:11674] [187795] (1 PDB entry)

   2. Species Feline immunodeficiency virus [TaxId:11673] [189983] (2 PDB entries)

   3. Species Hiv-1 m:b_arv2/sf2 [TaxId:11685] [188968] (6 PDB entries)

   4. Species Human immunodeficiency virus 1 (z2/cdc-z34 isolate) [TaxId:11683] [189840] (2 PDB entries)

   5. Species Human immunodeficiency virus 1 [TaxId:11676] [187327] (38 PDB entries)

   6. Species Human immunodeficiency virus type 1 (bru isolate) [TaxId:11686] [188980] (4 PDB entries)

   7. Species Human immunodeficiency virus type 1 (z2/cdc-z34 isolate) [TaxId:11683] [189175] (1 PDB entry)

   8. Species Human immunodeficiency virus type 1 [TaxId:11686] [193487] (1 PDB entry)

   9. Species Human immunodeficiency virus [TaxId:11686] [189979] (1 PDB entry)

   10. Species Human immunodeficiency virus [TaxId:12721] [188065] (4 PDB entries)

   11. Species Mason-pfizer monkey virus [TaxId:11855] [189736] (1 PDB entry)

More info for Family b.50.1.1: Retroviral protease (retropepsin)

Timeline for Family b.50.1.1: Retroviral protease (retropepsin):

• Family b.50.1.1: Retroviral protease (retropepsin) first appeared (with stable ids) in SCOP 1.55
  
• Family b.50.1.1: Retroviral protease (retropepsin) appears in SCOPe 2.01
  
• Family b.50.1.1: Retroviral protease (retropepsin) appears in SCOPe 2.03
  
• Family b.50.1.1: Retroviral protease (retropepsin) appears in the current release, SCOPe 2.08