SCOPe 2.01: Family b.47.1.4: Viral cysteine protease of trypsin fold

Lineage for Family b.47.1.4: Viral cysteine protease of trypsin fold

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (4 proteins)

Proteins:

1. 2A cysteine proteinase [50607] (1 species)

   • Species Human rhinovirus 2 [TaxId:12130] [50608] (1 PDB entry)

2. 3C cysteine protease (picornain 3C) [50604] (9 species)

   1. Species Foot-and-mouth disease virus [TaxId:12110] [159189] (2 PDB entries)
      Uniprot P49303 1657-1755! Uniprot P49303 1657-1857

   2. Species Human coxsackievirus a16 [TaxId:31704] [189721] (3 PDB entries)

   3. Species Human enterovirus 71 [TaxId:39054] [189720] (2 PDB entries)

   4. Species Human enterovirus b [TaxId:138949] [189732] (3 PDB entries)

   5. Species Human hepatitis a virus hu/northern africa/mbb/1978 [TaxId:12100] [186929] (2 PDB entries)

   6. Species Human hepatitis A virus [TaxId:208726] [50606] (5 PDB entries)

   7. Species Human poliovirus 1 Mahoney [TaxId:12081] [74978] (2 PDB entries)

   8. Species Human rhinovirus 2 [TaxId:12130] [50605] (1 PDB entry)

   9. Species Human rhinovirus sp. [TaxId:169066] [189940] (1 PDB entry)

3. Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (5 species)
   contains an extra alpha-helical domain

   1. Species Human coronavirus 229E [TaxId:11137] [89348] (2 PDB entries)

   2. Species Human coronavirus [TaxId:443239] [188597] (1 PDB entry)

   3. Species Sars coronavirus sin2774 [TaxId:235410] [187498] (2 PDB entries)

   4. Species SARS coronavirus [TaxId:227859] [89349] (55 PDB entries)

   5. Species Transmissible gastroenteritis virus [TaxId:11149] [74980] (3 PDB entries)

4. automated matches [190384] (8 species)
   not a true protein

   1. Species Coxsackievirus b3 [TaxId:103903] [188647] (1 PDB entry)

   2. Species Foot-and-mouth disease virus (strain a10-61) [TaxId:12112] [187901] (1 PDB entry)

   3. Species Foot-and-mouth disease virus [TaxId:12110] [187460] (1 PDB entry)

   4. Species Foot-and-mouth disease virus [TaxId:12112] [189099] (2 PDB entries)

   5. Species Human coxsackievirus B3 [TaxId:12072] [188738] (3 PDB entries)

   6. Species Human coxsackievirus [TaxId:12072] [188739] (1 PDB entry)

   7. Species Human sars coronavirus [TaxId:227859] [187234] (1 PDB entry)

   8. Species SARS coronavirus [TaxId:227859] [187411] (12 PDB entries)

More info for Family b.47.1.4: Viral cysteine protease of trypsin fold

Timeline for Family b.47.1.4: Viral cysteine protease of trypsin fold:

• Family b.47.1.4: Viral cysteine protease of trypsin fold first appeared (with stable ids) in SCOP 1.55
  
• Family b.47.1.4: Viral cysteine protease of trypsin fold appears in SCOP 1.75
  
• Family b.47.1.4: Viral cysteine protease of trypsin fold appears in SCOPe 2.02
  
• Family b.47.1.4: Viral cysteine protease of trypsin fold appears in the current release, SCOPe 2.08