SCOP 1.75: Family b.47.1.4: Viral cysteine protease of trypsin fold

Lineage for Family b.47.1.4: Viral cysteine protease of trypsin fold

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (3 proteins)

Proteins:

1. 2A cysteine proteinase [50607] (1 species)

   • Species Human rhinovirus 2 [TaxId:12130] [50608] (1 PDB entry)

2. 3C cysteine protease (picornain 3C) [50604] (4 species)

   1. Species Foot-and-mouth disease virus FMDV [TaxId:12110] [159189] (2 PDB entries)
      Uniprot P49303 1657-1755! Uniprot P49303 1657-1857

   2. Species Human hepatitis A virus [TaxId:208726] [50606] (7 PDB entries)

   3. Species Human poliovirus 1 Mahoney [TaxId:12081] [74978] (2 PDB entries)

   4. Species Human rhinovirus 2 [TaxId:12130] [50605] (1 PDB entry)

3. Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (3 species)
   contains an extra alpha-helical domain

   1. Species Human coronavirus 229E [TaxId:11137] [89348] (1 PDB entry)

   2. Species SARS coronavirus [TaxId:227859] [89349] (20 PDB entries)

   3. Species Transmissible gastroenteritis virus [TaxId:11149] [74980] (3 PDB entries)

More info for Family b.47.1.4: Viral cysteine protease of trypsin fold

Timeline for Family b.47.1.4: Viral cysteine protease of trypsin fold:

• Family b.47.1.4: Viral cysteine protease of trypsin fold first appeared (with stable ids) in SCOP 1.55
  
• Family b.47.1.4: Viral cysteine protease of trypsin fold appears in SCOP 1.73
  
• Family b.47.1.4: Viral cysteine protease of trypsin fold appears in SCOPe 2.01
  
• Family b.47.1.4: Viral cysteine protease of trypsin fold appears in the current release, SCOPe 2.08