Class b: All beta proteins [48724] (177 folds) |
Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily) barrel, closed; n=6, S=8; greek-key duplication: consists of two domains of the same fold |
Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) |
Family b.47.1.3: Viral proteases [50596] (5 proteins) beta sheet in the first domain is opened rather than forms a barrel |
Protein NS3 protease [50600] (5 species) |
Dengue virus 3 [TaxId:408693] [189803] (2 PDB entries) |
Domain d3u1ib1: 3u1i B:1-171 [186055] Other proteins in same PDB: d3u1ib2 automated match to d1befa_ complexed with so4 |
Domain d3u1id_: 3u1i D: [186056] Other proteins in same PDB: d3u1ib2 automated match to d1befa_ complexed with so4 |
Domain d3u1jb_: 3u1j B: [186057] Other proteins in same PDB: d3u1je_ automated match to d1befa_ |
Dengue virus type 2 [TaxId:11060] [50602] (1 PDB entry) |
Domain d2fomb1: 2fom B:18-167 [133884] Other proteins in same PDB: d2foma1, d2foma2, d2foma3 complexed with NS2B peptide cofactor complexed with cl, gol |
Hepatitis c virus subtype 1a [TaxId:31646] [254867] (2 PDB entries) |
Domain d3m5la1: 3m5l A:986-1179 [232887] Other proteins in same PDB: d3m5la2 automated match to d3sv8a_ complexed with so4, tsv, zn |
Domain d3rc6a1: 3rc6 A:986-1181 [265317] Other proteins in same PDB: d3rc6a2 automated match to d3sv6a_ complexed with zn |
Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries) Uniprot P27958 1027-1206,1678-1669 Uniprot P26662 1029-1202,1677-1689 Uniprot O36579 1054-1207 |
Domain d1a1qa_: 1a1q A: [26414] complexed with zn |
Domain d1a1qb_: 1a1q B: [26415] complexed with zn |
Domain d1a1qc_: 1a1q C: [26416] complexed with zn |
Domain d1a1r.1: 1a1r A:,C: [26406] complexed with zn |
Domain d1a1r.2: 1a1r B:,D: [26407] complexed with zn |
Domain d1bt7a1: 1bt7 A:22-180 [26418] Other proteins in same PDB: d1bt7a2 complexed with zn |
Domain d1cu1a1: 1cu1 A:705-720,A:3-186 [26408] Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3 complexed with po4, zn |
Domain d1cu1b1: 1cu1 B:1705-1720,B:1003-1186 [26409] Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3 complexed with po4, zn |
Domain d1dxp.1: 1dxp A:,C: [26404] complexed with gol, zn |
Domain d1dxp.2: 1dxp B:,D: [26405] complexed with gol, zn |
Domain d1dxwa1: 1dxw A:22-180 [26417] Other proteins in same PDB: d1dxwa2 complexed with 2zf, zn |
Domain d1dy8.1: 1dy8 A:,C: [26410] complexed with 0f7 |
Domain d1dy8.2: 1dy8 B:,D: [26411] complexed with 0f7 |
Domain d1dy9.1: 1dy9 A:,C: [26400] complexed with 2zf, zn |
Domain d1dy9.2: 1dy9 B:,D: [26401] complexed with 2zf, zn |
Domain d1jxp.1: 1jxp A:,C: [26402] complexed with zn |
Domain d1jxp.2: 1jxp B:,D: [26403] complexed with zn |
Domain d1n1l.1: 1n1l A:,C: [91544] complexed with trl, zn |
Domain d1n1l.2: 1n1l B:,D: [91545] complexed with trl, zn |
Domain d1ns3.1: 1ns3 A:,C: [26412] complexed with zn |
Domain d1ns3.2: 1ns3 B:,D: [26413] complexed with zn |
Domain d1rgq.1: 1rgq A:,D: [111803] complexed with akp, zn |
Domain d1rgq.2: 1rgq B:,C: [111804] complexed with akp, zn |
Domain d1rtl.1: 1rtl A:,C: [111934] complexed with cpx, zn |
Domain d1rtl.2: 1rtl B:,D: [144371] complexed with cpx, zn |
Domain d1w3c.1: 1w3c A:,C: [114138] complexed with dn1, dn2 |
Domain d1w3c.2: 1w3c B:,D: [114139] complexed with dn1, dn2 |
West Nile virus [TaxId:11082] [141386] (2 PDB entries) Uniprot P06935 1520-1671 |
Domain d2fp7b1: 2fp7 B:19-170 [133899] Other proteins in same PDB: d2fp7a1, d2fp7a2 complexed with NS2B cofactor |
Domain d2ijob1: 2ijo B:5-176 [145527] Other proteins in same PDB: d2ijoa_, d2ijoi_ complexed with NS2B cofactor, chain A |
Timeline for Protein NS3 protease from b.47.1.3: Viral proteases: