| Class b: All beta proteins [48724] (174 folds) |
| Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily) barrel, closed; n=6, S=8; greek-key duplication: consists of two domains of the same fold |
Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families) ![]() |
| Family b.47.1.3: Viral proteases [50596] (4 proteins) beta sheet in the first domain is opened rather than forms a barrel |
| Protein NS3 protease [50600] (4 species) |
| Dengue virus type 2 [TaxId:11060] [50602] (3 PDB entries) |
| Domain d1befa_: 1bef A: [26419] |
| Domain d1df9a_: 1df9 A: [26420] Other proteins in same PDB: d1df9c_ |
| Domain d1df9b_: 1df9 B: [26421] Other proteins in same PDB: d1df9c_ |
| Domain d2fomb1: 2fom B:18-167 [133884] complexed with NS2B peptide cofactor complexed with cl, gol |
| Dengue virus [TaxId:12637] [159188] (1 PDB entry) |
| Domain d2qida1: 2qid A:5-181 [150805] Other proteins in same PDB: d2qidc1 automatically matched to d1befa_ |
| Domain d2qidb1: 2qid B:305-481 [150806] Other proteins in same PDB: d2qidc1 automatically matched to d1befa_ |
| Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries) Uniprot P27958 1027-1206,1678-1669 Uniprot P26662 1029-1202,1677-1689 Uniprot O36579 1054-1207 |
| Domain d1a1qa_: 1a1q A: [26414] |
| Domain d1a1qb_: 1a1q B: [26415] |
| Domain d1a1qc_: 1a1q C: [26416] complexed with zn |
| Domain d1a1r.1: 1a1r A:,C: [26406] |
| Domain d1a1r.2: 1a1r B:,D: [26407] complexed with zn; mutant |
| Domain d1bt7a_: 1bt7 A: [26418] complexed with zn; mutant |
| Domain d1cu1a1: 1cu1 A:705-720,A:3-186 [26408] Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3 |
| Domain d1cu1b1: 1cu1 B:1705-1720,B:1003-1186 [26409] Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3 complexed with po4, zn |
| Domain d1dxp.1: 1dxp A:,C: [26404] |
| Domain d1dxp.2: 1dxp B:,D: [26405] complexed with gol, zn |
| Domain d1dxwa_: 1dxw A: [26417] complexed with abk, zn; mutant |
| Domain d1dy8.1: 1dy8 A:,C: [26410] |
| Domain d1dy8.2: 1dy8 B:,D: [26411] complexed with cbz, fki |
| Domain d1dy9.1: 1dy9 A:,C: [26400] |
| Domain d1dy9.2: 1dy9 B:,D: [26401] complexed with boc, fki, zn |
| Domain d1jxp.1: 1jxp A:,C: [26402] |
| Domain d1jxp.2: 1jxp B:,D: [26403] complexed with zn |
| Domain d1n1l.1: 1n1l A:,C: [91544] |
| Domain d1n1l.2: 1n1l B:,D: [91545] complexed with trl, zn; mutant |
| Domain d1ns3.1: 1ns3 A:,C: [26412] |
| Domain d1ns3.2: 1ns3 B:,D: [26413] complexed with zn; mutant |
| Domain d1rgq.1: 1rgq A:,D: [111803] |
| Domain d1rgq.2: 1rgq B:,C: [111804] complexed with akp, zn |
| Domain d1rtl.1: 1rtl A:,C: [111934] |
| Domain d1rtl.2: 1rtl B:,D: [144371] complexed with cpx, zn |
| Domain d1w3c.1: 1w3c A:,C: [114138] |
| Domain d1w3c.2: 1w3c B:,D: [114139] complexed with dn1, dn2; mutant |
| West nile virus [TaxId:11082] [141386] (2 PDB entries) Uniprot P06935 1520-1671 |
| Domain d2fp7b1: 2fp7 B:19-170 [133899] complexed with NS2B cofactor complexed with ndl |
| Domain d2ijob1: 2ijo B:5-176 [145527] Other proteins in same PDB: d2ijoi1 complexed with NS2B cofactor, chain A mutant |
Timeline for Protein NS3 protease from b.47.1.3: Viral proteases: