Lineage for Protein: NS3 protease

  1. Root: SCOP 1.75
  2. 781541Class b: All beta proteins [48724] (174 folds)
  3. 802045Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 802046Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families) (S)
  5. 803501Family b.47.1.3: Viral proteases [50596] (4 proteins)
    beta sheet in the first domain is opened rather than forms a barrel
  6. 803502Protein NS3 protease [50600] (4 species)

Species:

  1. 803503Dengue virus type 2 [TaxId:11060] [50602] (3 PDB entries)
    1. Domain for 1bef:
    2. Domains for 1df9:
      1. 803506Domain d1df9a_: 1df9 A: [26420]
        Other proteins in same PDB: d1df9c_
      2. 803507Domain d1df9b_: 1df9 B: [26421]
        Other proteins in same PDB: d1df9c_
    3. Domain for 2fom:
  2. 803508Dengue virus [TaxId:12637] [159188] (1 PDB entry)
  3. 803511Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries)
    Uniprot P27958 1027-1206,1678-1669
    Uniprot P26662 1029-1202,1677-1689
    Uniprot O36579 1054-1207
    1. Domains for 1a1q:
      1. 803530Domain d1a1qa_: 1a1q A: [26414]
      2. 803531Domain d1a1qb_: 1a1q B: [26415]
      3. 803532Domain d1a1qc_: 1a1q C: [26416]
        complexed with zn
    2. Domains for 1a1r:
      1. 803516Domain d1a1r.1: 1a1r A:,C: [26406]
      2. 803517Domain d1a1r.2: 1a1r B:,D: [26407]
        complexed with zn; mutant
    3. Domain for 1bt7:
    4. Domains for 1cu1:
      1. 803526Domain d1cu1a1: 1cu1 A:705-720,A:3-186 [26408]
        Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
      2. 803527Domain d1cu1b1: 1cu1 B:1705-1720,B:1003-1186 [26409]
        Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
        complexed with po4, zn
    5. Domains for 1dxp:
      1. 803520Domain d1dxp.1: 1dxp A:,C: [26404]
      2. 803521Domain d1dxp.2: 1dxp B:,D: [26405]
        complexed with gol, zn
    6. Domain for 1dxw:
    7. Domains for 1dy8:
      1. 803528Domain d1dy8.1: 1dy8 A:,C: [26410]
      2. 803529Domain d1dy8.2: 1dy8 B:,D: [26411]
        complexed with cbz, fki
    8. Domains for 1dy9:
      1. 803512Domain d1dy9.1: 1dy9 A:,C: [26400]
      2. 803513Domain d1dy9.2: 1dy9 B:,D: [26401]
        complexed with boc, fki, zn
    9. Domains for 1jxp:
      1. 803522Domain d1jxp.1: 1jxp A:,C: [26402]
      2. 803523Domain d1jxp.2: 1jxp B:,D: [26403]
        complexed with zn
    10. Domains for 1n1l:
      1. 803518Domain d1n1l.1: 1n1l A:,C: [91544]
      2. 803519Domain d1n1l.2: 1n1l B:,D: [91545]
        complexed with trl, zn; mutant
    11. Domains for 1ns3:
      1. 803533Domain d1ns3.1: 1ns3 A:,C: [26412]
      2. 803534Domain d1ns3.2: 1ns3 B:,D: [26413]
        complexed with zn; mutant
    12. Domains for 1rgq:
      1. 803535Domain d1rgq.1: 1rgq A:,D: [111803]
      2. 803536Domain d1rgq.2: 1rgq B:,C: [111804]
        complexed with akp, zn
    13. Domains for 1rtl:
      1. 803524Domain d1rtl.1: 1rtl A:,C: [111934]
      2. 803525Domain d1rtl.2: 1rtl B:,D: [144371]
        complexed with cpx, zn
    14. Domains for 1w3c:
      1. 803514Domain d1w3c.1: 1w3c A:,C: [114138]
      2. 803515Domain d1w3c.2: 1w3c B:,D: [114139]
        complexed with dn1, dn2; mutant
  4. 803539West nile virus [TaxId:11082] [141386] (2 PDB entries)
    Uniprot P06935 1520-1671
    1. Domain for 2fp7:
    2. Domain for 2ijo:

More info for Protein NS3 protease from b.47.1.3: Viral proteases

Timeline for Protein NS3 protease from b.47.1.3: Viral proteases: