SCOPe 2.08: Protein: NS3 protease

Lineage for Protein: NS3 protease

Root: SCOPe 2.08
Class b: All beta proteins [48724] (180 folds)
Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
barrel, closed; n=6, S=8; greek-key
duplication: consists of two domains of the same fold
Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)
Family b.47.1.3: Viral proteases [50596] (5 proteins)
beta sheet in the first domain is opened rather than forms a barrel
Protein NS3 protease [50600] (5 species)

Species:

Dengue virus 3 [TaxId:408693] [189803] (2 PDB entries)
1. Domains for 3u1i:
  1. Domain d3u1ib1: 3u1i B:1-171 [186055]
    Other proteins in same PDB: d3u1ib2
    automated match to d1befa_
    complexed with so4
  2. Domain d3u1id_: 3u1i D: [186056]
    Other proteins in same PDB: d3u1ib2
    automated match to d1befa_
    complexed with so4
2. Domain for 3u1j:
  - Domain d3u1jb_: 3u1j B: [186057]
    Other proteins in same PDB: d3u1je_
    automated match to d1befa_
Dengue virus type 2 [TaxId:11060] [50602] (1 PDB entry)
- Domain for 2fom:
  - Domain d2fomb1: 2fom B:18-167 [133884]
    Other proteins in same PDB: d2foma1, d2foma2, d2foma3
    complexed with NS2B peptide cofactor
    complexed with cl, gol
Hepatitis C virus subtype 1a [TaxId:31646] [254867] (2 PDB entries)
1. Domain for 3m5l:
  - Domain d3m5la1: 3m5l A:986-1179 [232887]
    Other proteins in same PDB: d3m5la2
    automated match to d3sv8a_
    complexed with so4, tsv, zn
2. Domain for 3rc6:
  - Domain d3rc6a1: 3rc6 A:986-1181 [265317]
    Other proteins in same PDB: d3rc6a2
    automated match to d3sv6a_
    complexed with zn
Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries)
Uniprot P27958 1027-1206,1678-1669
Uniprot P26662 1029-1202,1677-1689
Uniprot O36579 1054-1207
1. Domains for 1a1q:
  1. Domain d1a1qa_: 1a1q A: [26414]
    complexed with zn
  2. Domain d1a1qb_: 1a1q B: [26415]
    complexed with zn
  3. Domain d1a1qc_: 1a1q C: [26416]
    complexed with zn
2. Domains for 1a1r:
  1. Domain d1a1r.1: 1a1r A:,C: [26406]
    complexed with zn
  2. Domain d1a1r.2: 1a1r B:,D: [26407]
    complexed with zn
3. Domain for 1bt7:
  - Domain d1bt7a1: 1bt7 A:22-180 [26418]
    Other proteins in same PDB: d1bt7a2
    complexed with zn
4. Domains for 1cu1:
  1. Domain d1cu1a1: 1cu1 A:705-720,A:3-186 [26408]
    Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
    complexed with po4, zn
  2. Domain d1cu1b1: 1cu1 B:1705-1720,B:1003-1186 [26409]
    Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
    complexed with po4, zn
5. Domains for 1dxp:
  1. Domain d1dxp.1: 1dxp A:,C: [26404]
    complexed with gol, zn
  2. Domain d1dxp.2: 1dxp B:,D: [26405]
    complexed with gol, zn
6. Domain for 1dxw:
  - Domain d1dxwa1: 1dxw A:22-180 [26417]
    Other proteins in same PDB: d1dxwa2
    complexed with 2zf, zn
7. Domains for 1dy8:
  1. Domain d1dy8.1: 1dy8 A:,C: [26410]
    complexed with 0f7
  2. Domain d1dy8.2: 1dy8 B:,D: [26411]
    complexed with 0f7
8. Domains for 1dy9:
  1. Domain d1dy9.1: 1dy9 A:,C: [26400]
    complexed with 2zf, zn
  2. Domain d1dy9.2: 1dy9 B:,D: [26401]
    complexed with 2zf, zn
9. Domains for 1jxp:
  1. Domain d1jxp.1: 1jxp A:,C: [26402]
    complexed with zn
  2. Domain d1jxp.2: 1jxp B:,D: [26403]
    complexed with zn
10. Domains for 1n1l:
  1. Domain d1n1l.1: 1n1l A:,C: [91544]
    complexed with trl, zn
  2. Domain d1n1l.2: 1n1l B:,D: [91545]
    complexed with trl, zn
11. Domains for 1ns3:
  1. Domain d1ns3.1: 1ns3 A:,C: [26412]
    complexed with zn
  2. Domain d1ns3.2: 1ns3 B:,D: [26413]
    complexed with zn
12. Domains for 1rgq:
  1. Domain d1rgq.1: 1rgq A:,D: [111803]
    complexed with akp, zn
  2. Domain d1rgq.2: 1rgq B:,C: [111804]
    complexed with akp, zn
13. Domains for 1rtl:
  1. Domain d1rtl.1: 1rtl A:,C: [111934]
    complexed with cpx, zn
  2. Domain d1rtl.2: 1rtl B:,D: [144371]
    complexed with cpx, zn
14. Domains for 1w3c:
  1. Domain d1w3c.1: 1w3c A:,C: [114138]
    complexed with dn1, dn2
  2. Domain d1w3c.2: 1w3c B:,D: [114139]
    complexed with dn1, dn2
West Nile virus [TaxId:11082] [141386] (2 PDB entries)
Uniprot P06935 1520-1671
1. Domain for 2fp7:
  - Domain d2fp7b1: 2fp7 B:19-170 [133899]
    Other proteins in same PDB: d2fp7a1, d2fp7a2
    complexed with NS2B cofactor
2. Domain for 2ijo:
  - Domain d2ijob1: 2ijo B:5-176 [145527]
    Other proteins in same PDB: d2ijoa_, d2ijoi_
    complexed with NS2B cofactor, chain A

More info for Protein NS3 protease from b.47.1.3: Viral proteases

Timeline for Protein NS3 protease from b.47.1.3: Viral proteases:

Protein NS3 protease from b.47.1.3: Viral proteases first appeared (with stable ids) in SCOP 1.55
Protein NS3 protease from b.47.1.3: Viral proteases appears in SCOPe 2.07