Lineage for Protein: NS3 protease

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2387558Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2387559Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2389767Family b.47.1.3: Viral proteases [50596] (5 protein domains)
    beta sheet in the first domain is opened rather than forms a barrel
  6. 2389768Protein NS3 protease [50600] (5 species)

Species:

  1. 2389769Dengue virus 3 [TaxId:408693] [189803] (2 PDB entries)
    1. Domains for 3u1i:
      1. 2389771Domain d3u1ib1: 3u1i B:1-171 [186055]
        Other proteins in same PDB: d3u1ib2
        automated match to d1befa_
        complexed with so4
      2. 2389772Domain d3u1id_: 3u1i D: [186056]
        Other proteins in same PDB: d3u1ib2
        automated match to d1befa_
        complexed with so4
    2. Domain for 3u1j:
  2. 2389773Dengue virus type 2 [TaxId:11060] [50602] (1 PDB entry)
  3. 2389775Hepatitis C virus subtype 1a [TaxId:31646] [254867] (2 PDB entries)
    1. Domain for 3m5l:
    2. Domain for 3rc6:
  4. 2389778Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries)
    Uniprot P27958 1027-1206,1678-1669
    Uniprot P26662 1029-1202,1677-1689
    Uniprot O36579 1054-1207
    1. Domains for 1a1q:
      1. 2389795Domain d1a1qa_: 1a1q A: [26414]
        complexed with zn
      2. 2389796Domain d1a1qb_: 1a1q B: [26415]
        complexed with zn
      3. 2389797Domain d1a1qc_: 1a1q C: [26416]
        complexed with zn
    2. Domains for 1a1r:
      1. 2389785Domain d1a1r.1: 1a1r A:,C: [26406]
        complexed with zn
      2. 2389786Domain d1a1r.2: 1a1r B:,D: [26407]
        complexed with zn
    3. Domain for 1bt7:
    4. Domains for 1cu1:
      1. 2389800Domain d1cu1a1: 1cu1 A:705-720,A:3-186 [26408]
        Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
        complexed with po4, zn
      2. 2389801Domain d1cu1b1: 1cu1 B:1705-1720,B:1003-1186 [26409]
        Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
        complexed with po4, zn
    5. Domains for 1dxp:
      1. 2389789Domain d1dxp.1: 1dxp A:,C: [26404]
        complexed with gol, zn
      2. 2389790Domain d1dxp.2: 1dxp B:,D: [26405]
        complexed with gol, zn
    6. Domain for 1dxw:
    7. Domains for 1dy8:
      1. 2389791Domain d1dy8.1: 1dy8 A:,C: [26410]
        complexed with 0f7
      2. 2389792Domain d1dy8.2: 1dy8 B:,D: [26411]
        complexed with 0f7
    8. Domains for 1dy9:
      1. 2389779Domain d1dy9.1: 1dy9 A:,C: [26400]
        complexed with 2zf, zn
      2. 2389780Domain d1dy9.2: 1dy9 B:,D: [26401]
        complexed with 2zf, zn
    9. Domains for 1jxp:
      1. 2389781Domain d1jxp.1: 1jxp A:,C: [26402]
        complexed with zn
      2. 2389782Domain d1jxp.2: 1jxp B:,D: [26403]
        complexed with zn
    10. Domains for 1n1l:
      1. 2389783Domain d1n1l.1: 1n1l A:,C: [91544]
        complexed with trl, zn
      2. 2389784Domain d1n1l.2: 1n1l B:,D: [91545]
        complexed with trl, zn
    11. Domains for 1ns3:
      1. 2389793Domain d1ns3.1: 1ns3 A:,C: [26412]
        complexed with zn
      2. 2389794Domain d1ns3.2: 1ns3 B:,D: [26413]
        complexed with zn
    12. Domains for 1rgq:
      1. 2389802Domain d1rgq.1: 1rgq A:,D: [111803]
        complexed with akp, zn
      2. 2389803Domain d1rgq.2: 1rgq B:,C: [111804]
        complexed with akp, zn
    13. Domains for 1rtl:
      1. 2389787Domain d1rtl.1: 1rtl A:,C: [111934]
        complexed with cpx, zn
      2. 2389788Domain d1rtl.2: 1rtl B:,D: [144371]
        complexed with cpx, zn
    14. Domains for 1w3c:
      1. 2389798Domain d1w3c.1: 1w3c A:,C: [114138]
        complexed with dn1, dn2
      2. 2389799Domain d1w3c.2: 1w3c B:,D: [114139]
        complexed with dn1, dn2
  5. 2389806West Nile virus [TaxId:11082] [141386] (2 PDB entries)
    Uniprot P06935 1520-1671
    1. Domain for 2fp7:
    2. Domain for 2ijo:

More info for Protein NS3 protease from b.47.1.3: Viral proteases

Timeline for Protein NS3 protease from b.47.1.3: Viral proteases: