SCOPe 2.05: Family b.47.1.3: Viral proteases

Lineage for Family b.47.1.3: Viral proteases

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.3: Viral proteases [50596] (5 proteins)
   beta sheet in the first domain is opened rather than forms a barrel

Proteins:

1. NS3 protease [50600] (5 species)

   1. Species Dengue virus 3 [TaxId:408693] [189803] (2 PDB entries)

   2. Species Dengue virus type 2 [TaxId:11060] [50602] (1 PDB entry)

   3. Species Hepatitis c virus subtype 1a [TaxId:31646] [254867] (2 PDB entries)

   4. Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries)
      Uniprot P27958 1027-1206,1678-1669
      Uniprot P26662 1029-1202,1677-1689
      Uniprot O36579 1054-1207

   5. Species West Nile virus [TaxId:11082] [141386] (2 PDB entries)
      Uniprot P06935 1520-1671

2. NSP4 proteinase [82128] (1 species)
   minimal fold; contains C-terminal extension

   • Species Equine arteritis virus, EAV [TaxId:11047] [82129] (1 PDB entry)

3. TEV protease (nucleat inclusion protein A, NIA) [82126] (1 species)

   • Species Tobacco etch virus, TEV [TaxId:12227] [82127] (3 PDB entries)
     Uniprot P04517 2041-2279

4. Viral capsid protein [50597] (3 species)

   1. Species Semliki forest virus [TaxId:11033] [50599] (2 PDB entries)

   2. Species Sindbis virus [TaxId:11034] [50598] (11 PDB entries)

   3. Species Venezuelan equine encephalitis virus [TaxId:11036] [89347] (2 PDB entries)

5. automated matches [190658] (4 species)
   not a true protein

   1. Species Aura virus [TaxId:44158] [194195] (3 PDB entries)

   2. Species Hepatitis C virus subtype 1a [TaxId:31646] [226463] (19 PDB entries)

   3. Species Hepatitis C virus [TaxId:11103] [189262] (8 PDB entries)

   4. Species West Nile virus [TaxId:11082] [187751] (2 PDB entries)

More info for Family b.47.1.3: Viral proteases

Timeline for Family b.47.1.3: Viral proteases:

• Family b.47.1.3: Viral proteases first appeared (with stable ids) in SCOP 1.55
  
• Family b.47.1.3: Viral proteases appears in SCOPe 2.04
  
• Family b.47.1.3: Viral proteases appears in SCOPe 2.06
  
• Family b.47.1.3: Viral proteases appears in the current release, SCOPe 2.08