Lineage for Family b.47.1.2: Eukaryotic proteases

  1. Root: SCOPe 2.05
  2. 1755445Class b: All beta proteins [48724] (176 folds)
  3. 1793083Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 1793084Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 1793331Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

Proteins:

  1. 1793332(alpha,gamma)-chymotrypsin(ogen) [50522] (3 species)
    1. 1793333Species Cow (Bos taurus) [TaxId:9913] [50523] (59 PDB entries)
      Uniprot P00766
    2. 1793421Species Norway rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry)
    3. 1793423Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry)
  2. 17934267S NGF protease subunits [50559] (1 species)
    two pairs of homologous but non-identical chains
  3. 1793432Activated protein c (autoprothrombin IIa) [50579] (1 species)
  4. 1793436Alpha tryptase I [89341] (1 species)
  5. 1793442Beta-acrosin [50593] (2 species)
    1. 1793443Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry)
    2. 1793445Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry)
  6. 1793447beta-Tryptase [50546] (1 species)
    ring-like tetramer with active sites facing a central pore
  7. 1793511Cathepsin G [50548] (1 species)
  8. 1793517Chymase (mast cell protease I) [89343] (1 species)
  9. 1793530Chymase II (mast cell proteinase II) [50552] (1 species)
  10. 1793534Coagulation factor IXa, protease domain [50583] (2 species)
    1. 1793535Species Human (Homo sapiens) [TaxId:9606] [50585] (9 PDB entries)
    2. 1793546Species Pig (Sus scrofa) [TaxId:9823] [50584] (2 PDB entries)
  11. 1793549Coagulation factor VIIa [50550] (1 species)
  12. 1793602Coagulation factor Xa, protease domain [50574] (2 species)
    1. 1793603Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry)
    2. 1793605Species Human (Homo sapiens) [TaxId:9606] [50575] (55 PDB entries)
      Uniprot P00742 235-467
  13. 1793666Coagulation factor Xa-trypsin chimera [50577] (1 species)
  14. 1793669Coagulation factor XI [117237] (1 species)
  15. Complement C1R protease, catalytic domain [74976] (1 species)
  16. 1793713Complement C1S protease, catalytic domain [63789] (1 species)
  17. 1793716Crab collagenase [50527] (1 species)
  18. 1793720Duodenase [63791] (1 species)
    new serine protease
  19. 1793723Elastase [50536] (4 species)
    1. 1793724Species Atlantic salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry)
    2. 1793726Species Human (Homo sapiens) [TaxId:9606] [50537] (11 PDB entries)
    3. 1793740Species Pig (Sus scrofa) [TaxId:9823] [50538] (117 PDB entries)
    4. 1793860Species Worm (Eisenia fetida) [TaxId:6396] [74973] (1 PDB entry)
      fibrinolytic enzyme component A
  20. 1793864Enteropeptidase (enterokinase light chain) [50540] (1 species)
  21. 1793867Factor B [50561] (1 species)
  22. 1793874Factor D [50563] (1 species)
  23. 1793897Granzyme A [89345] (1 species)
  24. 1793906Granzyme B [50590] (2 species)
    1. 1793907Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries)
    2. 1793911Species Norway rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry)
  25. 1793914Granzyme K [82124] (1 species)
  26. 1793918Heparin binding protein, HBP [50544] (1 species)
    multifunctional protein (synonym: CAP37, azurocidin)
  27. 1793924Hepatocyte growth factor activator, HGFA [267665] (1 species)
  28. 1793929Hepatocyte growth factor, HGF [110239] (1 species)
  29. 1793933Hepsin, catalytic domain [101813] (1 species)
  30. 1793939HL collagenase [50529] (1 species)
  31. 1793945Kallikrein 6 [74974] (1 species)
  32. 1793950Kallikrein A [50555] (1 species)
  33. 1793957Kallikrein-13 [50572] (1 species)
  34. 1793961Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241] (1 species)
  35. 1793966Matriptase MTSP1 [69284] (1 species)
  36. 1793988Myeloblastin, PR3 [50581] (1 species)
  37. 1793994Neuropsin [50525] (1 species)
  38. 1793998Plasmin(ogen), catalytic domain [50588] (1 species)
  39. 1794017Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species)
  40. 1794022Prostate specific antigen (PSA kallikrein) [82122] (1 species)
  41. 1794025Single chain tissue plasminogen activator [50567] (2 species)
    1. 1794026Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry)
    2. 1794029Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry)
  42. 1794031Thrombin [50531] (2 species)
    1. Species Cow (Bos taurus) [TaxId:9913] [50533] (19 PDB entries)
      Uniprot P00734 333-622
    2. 1794067Species Human (Homo sapiens) [TaxId:9606] [50532] (169 PDB entries)
      Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620
  43. 1794261Tonin [50557] (1 species)
  44. 1794264Trypsin(ogen) [50515] (9 species)
    1. 1794265Species Atlantic salmon (Salmo salar) [TaxId:8030] [50520] (11 PDB entries)
    2. 1794280Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry)
    3. 1794282Species Cow (Bos taurus) [TaxId:9913] [50516] (396 PDB entries)
      Uniprot P00760
    4. 1794697Species Fungus (Fusarium oxysporum) [TaxId:5507] [50521] (16 PDB entries)
    5. 1794714Species Human (Homo sapiens) [TaxId:9606] [50519] (4 PDB entries)
    6. 1794723Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (9 PDB entries)
    7. 1794747Species Narrow-clawed crayfish (Pontastacus leptodactylus) [TaxId:6717] [141385] (2 PDB entries)
      Uniprot Q52V24 1-237
    8. 1794751Species Norway rat (Rattus norvegicus) [TaxId:10116] [50518] (36 PDB entries)
    9. 1794792Species Pig (Sus scrofa) [TaxId:9823] [50517] (33 PDB entries)
      Uniprot P00761 9-231 ! Uniprot P00761
  45. 1794831Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species)
  46. 1794836Urokinase [50542] (1 species)
  47. 1794839Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species)
  48. 1794914Venom serine protease [50570] (2 species)
    1. 1794915Species Chinese green tree viper (Trimeresurus stejnegeri) [TaxId:39682] [50571] (1 PDB entry)
    2. 1794918Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [110238] (2 PDB entries)
      Uniprot Q9I8X1
  49. 1794921automated matches [190044] (14 species)
    not a true protein
    1. 1794922Species Agkistrodon contortrix [TaxId:8713] [187405] (2 PDB entries)
    2. 1794925Species Atlantic cod (Gadus morhua) [TaxId:8049] [188345] (1 PDB entry)
    3. 1794927Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [189036] (3 PDB entries)
    4. 1794933Species Cow (Bos taurus) [TaxId:9913] [187001] (12 PDB entries)
    5. 1794949Species Daboia russellii [TaxId:343250] [196182] (3 PDB entries)
    6. 1794953Species Gloydius saxatilis [TaxId:92067] [195310] (1 PDB entry)
    7. 1794955Species Golden hamster (Mesocricetus auratus) [TaxId:10036] [188254] (1 PDB entry)
    8. 1794958Species Halys viper (Agkistrodon halys) [TaxId:8714] [195671] (1 PDB entry)
    9. 1794960Species Human (Homo sapiens) [TaxId:9606] [187233] (136 PDB entries)
    10. 1795125Species Jararacussu (Bothrops jararacussu) [TaxId:8726] [194232] (1 PDB entry)
    11. 1795127Species Macaca mulatta [TaxId:9541] [196009] (1 PDB entry)
    12. 1795130Species Mouse (Mus musculus) [TaxId:10090] [188816] (2 PDB entries)
    13. 1795135Species Oryzias latipes [TaxId:8090] [237103] (1 PDB entry)
    14. 1795138Species Pig (Sus scrofa) [TaxId:9823] [193403] (1 PDB entry)

More info for Family b.47.1.2: Eukaryotic proteases

Timeline for Family b.47.1.2: Eukaryotic proteases: