Lineage for Family b.47.1.2: Eukaryotic proteases

  1. Root: SCOPe 2.02
  2. 1103260Class b: All beta proteins [48724] (174 folds)
  3. 1127558Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 1127559Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 1127765Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

Proteins:

  1. 1127766(alpha,gamma)-chymotrypsin(ogen) [50522] (3 species)
    1. 1127767Species Cow (Bos taurus) [TaxId:9913] [50523] (58 PDB entries)
      Uniprot P00766
    2. 1127851Species Norway rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry)
    3. 1127853Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry)
  2. 11278567S NGF protease subunits [50559] (1 species)
    two pairs of homologous but non-identical chains
  3. 1127862Activated protein c (autoprothrombin IIa) [50579] (1 species)
  4. 1127866Alpha tryptase I [89341] (1 species)
  5. 1127872Beta-acrosin [50593] (2 species)
    1. 1127873Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry)
    2. 1127875Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry)
  6. 1127877beta-Tryptase [50546] (1 species)
    ring-like tetramer with active sites facing a central pore
  7. 1127931Cathepsin G [50548] (1 species)
  8. 1127937Chymase (mast cell protease I) [89343] (1 species)
  9. 1127947Chymase II (mast cell proteinase II) [50552] (1 species)
  10. 1127951Coagulation factor IXa, protease domain [50583] (2 species)
    1. 1127952Species Human (Homo sapiens) [TaxId:9606] [50585] (5 PDB entries)
    2. 1127959Species Pig (Sus scrofa) [TaxId:9823] [50584] (2 PDB entries)
  11. 1127962Coagulation factor VIIa [50550] (1 species)
  12. 1127998Coagulation factor Xa, protease domain [50574] (2 species)
    1. 1127999Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry)
    2. 1128001Species Human (Homo sapiens) [TaxId:9606] [50575] (46 PDB entries)
      Uniprot P00742 235-467
  13. 1128050Coagulation factor Xa-trypsin chimera [50577] (1 species)
  14. 1128053Coagulation factor XI [117237] (1 species)
  15. 1128084Complement C1R protease, catalytic domain [74976] (1 species)
  16. 1128092Complement C1S protease, catalytic domain [63789] (1 species)
  17. 1128095Crab collagenase [50527] (1 species)
  18. 1128099Duodenase [63791] (1 species)
    new serine protease
  19. 1128102Elastase [50536] (4 species)
    1. 1128103Species Atlantic salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry)
    2. 1128105Species Human (Homo sapiens) [TaxId:9606] [50537] (5 PDB entries)
    3. 1128112Species Pig (Sus scrofa) [TaxId:9823] [50538] (116 PDB entries)
    4. 1128231Species Worm (Eisenia fetida) [TaxId:6396] [74973] (1 PDB entry)
      fibrinolytic enzyme component A
  20. 1128235Enteropeptidase (enterokinase light chain) [50540] (1 species)
  21. 1128238Factor B [50561] (1 species)
  22. 1128245Factor D [50563] (1 species)
  23. 1128264Granzyme A [89345] (1 species)
  24. 1128273Granzyme B [50590] (2 species)
    1. 1128274Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries)
    2. 1128278Species Norway rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry)
  25. 1128281Granzyme K [82124] (1 species)
  26. 1128285Heparin binding protein, HBP [50544] (1 species)
    multifunctional protein (synonym: CAP37, azurocidin)
  27. 1128291Hepatocyte growth factor, HGF [110239] (1 species)
  28. 1128295Hepsin, catalytic domain [101813] (1 species)
  29. 1128301HL collagenase [50529] (1 species)
  30. 1128307Kallikrein 6 [74974] (1 species)
  31. 1128312Kallikrein A [50555] (1 species)
  32. 1128319Kallikrein-13 [50572] (1 species)
  33. 1128323Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241] (1 species)
  34. 1128328Matriptase MTSP1 [69284] (1 species)
  35. 1128343Myeloblastin, PR3 [50581] (1 species)
  36. 1128349Neuropsin [50525] (1 species)
  37. 1128353Plasmin(ogen), catalytic domain [50588] (1 species)
  38. 1128371Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species)
  39. 1128376Prostate specific antigen (PSA kallikrein) [82122] (1 species)
  40. 1128379Single chain tissue plasminogen activator [50567] (2 species)
    1. 1128380Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry)
    2. 1128383Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry)
  41. 1128385Thrombin [50531] (2 species)
    1. 1128386Species Cow (Bos taurus) [TaxId:9913] [50533] (26 PDB entries)
      Uniprot P00734 333-622
    2. 1128432Species Human (Homo sapiens) [TaxId:9606] [50532] (160 PDB entries)
      Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620
  42. 1128612Tonin [50557] (1 species)
  43. 1128615Trypsin(ogen) [50515] (9 species)
    1. 1128616Species Atlantic salmon (Salmo salar) [TaxId:8030] [50520] (11 PDB entries)
    2. 1128631Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry)
    3. 1128633Species Cow (Bos taurus) [TaxId:9913] [50516] (392 PDB entries)
      Uniprot P00760
    4. 1129044Species Fungus (Fusarium oxysporum) [TaxId:5507] [50521] (16 PDB entries)
    5. 1129061Species Human (Homo sapiens) [TaxId:9606] [50519] (2 PDB entries)
    6. 1129066Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (7 PDB entries)
    7. 1129083Species Narrow-clawed crayfish (Pontastacus leptodactylus) [TaxId:6717] [141385] (1 PDB entry)
      Uniprot Q52V24 1-237
    8. 1129085Species Norway rat (Rattus norvegicus) [TaxId:10116] [50518] (36 PDB entries)
    9. 1129126Species Pig (Sus scrofa) [TaxId:9823] [50517] (24 PDB entries)
      Uniprot P00761 9-231 ! Uniprot P00761
  44. 1129156Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species)
  45. 1129161Urokinase [50542] (1 species)
  46. 1129164Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species)
  47. 1129214Venom serine protease [50570] (2 species)
    1. 1129215Species Chinese green tree viper (Trimeresurus stejnegeri) [TaxId:39682] [50571] (1 PDB entry)
    2. 1129218Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [110238] (2 PDB entries)
      Uniprot Q9I8X1
  48. 1129221automated matches [190044] (13 species)
    not a true protein
    1. 1129222Species Agkistrodon contortrix [TaxId:8713] [187405] (2 PDB entries)
    2. 1129225Species Agkistrodon halys [TaxId:8714] [195671] (1 PDB entry)
    3. 1129227Species Atlantic cod (Gadus morhua) [TaxId:8049] [188345] (1 PDB entry)
    4. 1129229Species Bothrops jararacussu [TaxId:8726] [194232] (1 PDB entry)
    5. 1129231Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [189036] (3 PDB entries)
    6. 1129237Species Cow (Bos taurus) [TaxId:9913] [187001] (8 PDB entries)
    7. 1129246Species Daboia russellii [TaxId:343250] [196182] (1 PDB entry)
    8. 1129248Species Gloydius saxatilis [TaxId:92067] [195310] (1 PDB entry)
    9. 1129250Species Golden hamster (Mesocricetus auratus) [TaxId:10036] [188254] (1 PDB entry)
    10. 1129253Species Human (Homo sapiens) [TaxId:9606] [187233] (122 PDB entries)
    11. Species Macaca mulatta [TaxId:9541] [196009] (1 PDB entry)
    12. 1129392Species Mouse (Mus musculus) [TaxId:10090] [188816] (2 PDB entries)
    13. 1129397Species Sus scrofa [TaxId:9823] [193403] (1 PDB entry)

More info for Family b.47.1.2: Eukaryotic proteases

Timeline for Family b.47.1.2: Eukaryotic proteases: