Lineage for Family b.47.1.2: Eukaryotic proteases

  1. Root: SCOP 1.75
  2. 781541Class b: All beta proteins [48724] (174 folds)
  3. 802045Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 802046Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families) (S)
  5. 802237Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins)

Proteins:

  1. 802238(alpha,gamma)-chymotrypsin(ogen) [50522] (3 species)
    1. 802239Species Cow (Bos taurus) [TaxId:9913] [50523] (56 PDB entries)
      Uniprot P00766
    2. 802316Species Rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry)
    3. 802318Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry)
  2. 8023217S NGF protease subunits [50559] (1 species)
    two pairs of homologous but non-identical chains
  3. 802327Activated protein c (autoprothrombin IIa) [50579] (1 species)
  4. 802330Alpha tryptase I [89341] (1 species)
  5. 802336Beta-acrosin [50593] (2 species)
    1. 802337Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry)
    2. 802339Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry)
  6. 802341beta-Tryptase [50546] (1 species)
    ring-like tetramer with active sites facing a central pore
  7. 802379Cathepsin G [50548] (1 species)
  8. 802386Chymase (mast cell protease I) [89343] (1 species)
  9. 802389Chymase II (mast cell proteinase II) [50552] (2 species)
    1. 802390Species Human (Homo sapiens) [TaxId:9606] [50554] (4 PDB entries)
    2. 802395Species Rat (Rattus rattus) [TaxId:10117] [50553] (1 PDB entry)
  10. 802398Coagulation factor IXa, protease domain [50583] (2 species)
    1. 802399Species Human (Homo sapiens) [TaxId:9606] [50585] (1 PDB entry)
    2. 802401Species Pig (Sus scrofa) [TaxId:9823] [50584] (2 PDB entries)
  11. 802404Coagulation factor VIIa [50550] (1 species)
  12. 802442Coagulation factor Xa, protease domain [50574] (2 species)
    1. 802443Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry)
    2. 802445Species Human (Homo sapiens) [TaxId:9606] [50575] (75 PDB entries)
      Uniprot P00742 235-467
  13. 802523Coagulation factor Xa-trypsin chimera [50577] (1 species)
  14. 802526Coagulation factor XI [117237] (1 species)
  15. 802535Complement C1R protease, catalytic domain [74976] (1 species)
  16. 802543Complement C1S protease, catalytic domain [63789] (1 species)
  17. 802546Crab collagenase [50527] (1 species)
  18. 802550Duodenase [63791] (1 species)
    new serine protease
  19. 802553Elastase [50536] (4 species)
    1. 802554Species Human (Homo sapiens) [TaxId:9606] [50537] (7 PDB entries)
    2. 802563Species Pig (Sus scrofa) [TaxId:9823] [50538] (94 PDB entries)
    3. 802660Species Salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry)
    4. 802662Species Worm (Eisenia fetida) [TaxId:6396] [74973] (1 PDB entry)
      fibrinolytic enzyme component A
  20. 802666Enteropeptidase (enterokinase light chain) [50540] (1 species)
  21. 802669Factor B [50561] (1 species)
  22. 802676Factor D [50563] (1 species)
  23. 802690Granzyme A [89345] (1 species)
  24. 802699Granzyme B [50590] (2 species)
    1. 802700Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries)
    2. 802704Species Rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry)
  25. 802707Granzyme K [82124] (1 species)
  26. 802711Heparin binding protein, HBP [50544] (1 species)
    multifunctional protein (synonym: CAP37, azurocidin)
  27. 802717Hepatocyte growth factor, HGF [110239] (1 species)
  28. 802721Hepsin, catalytic domain [101813] (1 species)
  29. 802727HL collagenase [50529] (1 species)
  30. 802733Kallikrein 6 [74974] (1 species)
  31. 802738Kallikrein A [50555] (1 species)
  32. 802745Kallikrein-13 [50572] (1 species)
  33. 802749Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241] (1 species)
  34. 802754Matriptase MTSP1 [69284] (1 species)
  35. 802761Myeloblastin, PR3 [50581] (1 species)
  36. 802767Neuropsin [50525] (1 species)
  37. 802771Plasmin(ogen), catalytic domain [50588] (1 species)
  38. 802788Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species)
  39. 802793Prostate specific antigen (PSA kallikrein) [82122] (1 species)
  40. 802796Single chain tissue plasminogen activator [50567] (2 species)
    1. 802797Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry)
    2. 802800Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry)
  41. 802802Thrombin [50531] (2 species)
    1. 802803Species Cow (Bos taurus) [TaxId:9913] [50533] (26 PDB entries)
      Uniprot P00734 333-622
    2. 802849Species Human (Homo sapiens) [TaxId:9606] [50532] (164 PDB entries)
      Uniprot P00734 331-361,364-421
      Uniprot P00734 334-360 364-510 518-619
      Uniprot P00734 328-620
      Uniprot P00734 355-621
      Uniprot P00734 328-620
      Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620
  42. 803033Tonin [50557] (1 species)
  43. 803036Trypsin(ogen) [50515] (9 species)
    1. 803037Species Cow (Bos taurus) [TaxId:9913] [50516] (279 PDB entries)
      Uniprot P00760
    2. 803327Species Human (Homo sapiens) [TaxId:9606] [50519] (1 PDB entry)
    3. 803330Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (1 PDB entry)
    4. 803332Species Mold (Fusarium oxysporum) [TaxId:5507] [50521] (16 PDB entries)
    5. 803349Species Narrow-clawed crayfish (Pontastacus leptodactylus) [TaxId:6717] [141385] (1 PDB entry)
      Uniprot Q52V24 1-237
    6. 803351Species North atlantic salmon (Salmo salar) [TaxId:8030] [50520] (11 PDB entries)
    7. 803366Species Pacific chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry)
    8. 803368Species Pig (Sus scrofa) [TaxId:9823] [50517] (23 PDB entries)
      Uniprot P00761 9-231
      Uniprot P00761
      Uniprot P00761 9-231 ! Uniprot P00761
    9. 803396Species Rat (Rattus norvegicus) [TaxId:10116] [50518] (33 PDB entries)
  44. 803434Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species)
  45. 803439Urokinase [50542] (1 species)
  46. 803442Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species)
  47. 803494Venom serine protease [50570] (2 species)
    1. 803495Species Chinese green tree viper (Trimeresurus stejnegeri) [TaxId:39682] [50571] (1 PDB entry)
    2. 803498Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [110238] (2 PDB entries)
      Uniprot Q9I8X1

More info for Family b.47.1.2: Eukaryotic proteases

Timeline for Family b.47.1.2: Eukaryotic proteases: