Lineage for Family b.47.1.2: Eukaryotic proteases

  1. Root: SCOP 1.65
  2. 287094Class b: All beta proteins [48724] (126 folds)
  3. 298675Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 298676Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families) (S)
  5. 298774Family b.47.1.2: Eukaryotic proteases [50514] (43 proteins)

Proteins:

  1. 298775(alpha,gamma)-chymotrypsin(ogen) [50522] (3 species)
    1. 298776Species Cow (Bos taurus) [TaxId:9913] [50523] (46 PDB entries)
    2. 298833Species Rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry)
    3. 298835Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry)
  2. 2988387S NGF protease subunits [50559] (1 species)
    two pairs of homologous but non-identical chains
  3. 298844Activated protein c (autoprothrombin IIa) [50579] (1 species)
  4. 298847Alpha tryptase I [89341] (1 species)
  5. 298853Beta-acrosin [50593] (2 species)
    1. 298854Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry)
    2. 298856Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry)
  6. 298858beta-Tryptase [50546] (1 species)
    ring-like tetramer with active sites facing a central pore
  7. 298864Cathepsin G [50548] (1 species)
  8. 298870Chymase (mast cell protease I) [89343] (1 species)
  9. 298873Chymase II (mast cell proteinase II) [50552] (2 species)
    1. 298874Species Human (Homo sapiens) [TaxId:9606] [50554] (2 PDB entries)
    2. 298877Species Rat (Rattus rattus) [TaxId:10117] [50553] (1 PDB entry)
  10. 298880Coagulation factor IXa, protease domain [50583] (2 species)
    1. 298881Species Human (Homo sapiens) [TaxId:9606] [50585] (1 PDB entry)
    2. 298883Species Pig (Sus scrofa) [TaxId:9823] [50584] (1 PDB entry)
  11. 298885Coagulation factor VIIa [50550] (1 species)
  12. 298896Coagulation factor Xa (Chrismas factor), protease domain [50574] (2 species)
    1. 298897Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry)
    2. 298899Species Human (Homo sapiens) [TaxId:9606] [50575] (23 PDB entries)
  13. 298924Coagulation factor Xa-trypsin chimera [50577] (1 species)
  14. 298927Complement C1R protease, catalytic domain [74976] (1 species)
  15. 298931Complement C1S protease, catalytic domain [63789] (1 species)
  16. 298934Crab collagenase [50527] (1 species)
  17. 298938Duodenase [63791] (1 species)
    new serine protease
  18. 298941Elastase [50536] (4 species)
    1. 298942Species Earthworm (Eisenia fetida) [74973] (1 PDB entry)
      fibrinolytic enzyme component A
    2. 298946Species Human (Homo sapiens) [TaxId:9606] [50537] (5 PDB entries)
    3. 298953Species Pig (Sus scrofa) [TaxId:9823] [50538] (56 PDB entries)
    4. 299011Species Salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry)
  19. 299013Enteropeptidase (enterokinase light chain) [50540] (1 species)
  20. 299016Factor B [50561] (1 species)
  21. 299020Factor D [50563] (1 species)
  22. 299034Granzyme A [89345] (1 species)
  23. 299043Granzyme B [50590] (2 species)
    1. 299044Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries)
    2. 299048Species Rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry)
  24. 299051Granzyme K [82124] (1 species)
  25. 299055Heparin binding protein, HBP [50544] (1 species)
    multifunctional protein (synonym: CAP37, azurocidin)
  26. 299061HL collagenase [50529] (1 species)
  27. 299067Kallikrein 6 [74974] (1 species)
  28. 299072Kallikrein A [50555] (1 species)
  29. 299079Kallikrein-13 [50572] (1 species)
  30. 299083Matriptase MTSP1 [69284] (1 species)
  31. 299088Myeloblastin, PR3 [50581] (1 species)
  32. 299094Neuropsin [50525] (1 species)
  33. 299098Plasmin(ogen), catalytic domain [50588] (1 species)
  34. 299114Plasminogen activator from snake venom, TSV-PA [50570] (1 species)
  35. 299118Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species)
  36. 299123Prostate specific antigen (PSA kallikrein) [82122] (1 species)
  37. 299126Single chain tissue plasminogen activator [50567] (2 species)
    1. 299127Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry)
    2. 299130Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry)
  38. 299132Thrombin [50531] (2 species)
    1. 299133Species Cow (Bos taurus) [TaxId:9913] [50533] (19 PDB entries)
    2. 299168Species Human (Homo sapiens) [TaxId:9606] [50532] (137 PDB entries)
  39. 299317Tonin [50557] (1 species)
  40. 299320Trypsin(ogen) [50515] (8 species)
    1. 299321Species Cow (Bos taurus) [TaxId:9913] [50516] (160 PDB entries)
    2. 299489Species Human (Homo sapiens) [TaxId:9606] [50519] (1 PDB entry)
    3. 299492Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (1 PDB entry)
    4. 299494Species Mold (Fusarium oxysporum) [TaxId:5507] [50521] (7 PDB entries)
    5. 299502Species North atlantic salmon (Salmo salar) [TaxId:8030] [50520] (7 PDB entries)
    6. 299513Species Pacific chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry)
    7. 299515Species Pig (Sus scrofa) [TaxId:9823] [50517] (14 PDB entries)
    8. 299531Species Rat (Rattus norvegicus) [TaxId:10116] [50518] (30 PDB entries)
  41. 299566Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species)
  42. 299571Urokinase [50542] (1 species)
  43. 299574Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species)

More info for Family b.47.1.2: Eukaryotic proteases

Timeline for Family b.47.1.2: Eukaryotic proteases: