SCOPe 2.05: Family b.42.1.2: Interleukin-1 (IL-1)

Lineage for Family b.42.1.2: Interleukin-1 (IL-1)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.42: beta-Trefoil [50352] (8 superfamilies)
   barrel, closed; n=6, S=12; and a hairpin triplet; meander
   duplication: has internal pseudo threefold symmetry

4. Superfamily b.42.1: Cytokine [50353] (3 families)

5. Family b.42.1.2: Interleukin-1 (IL-1) [50362] (6 proteins)

Proteins:

1. Interleukin-1 receptor antagonist protein [50366] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50367] (5 PDB entries)

2. Interleukin-18 [101782] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [101783] (4 PDB entries)

3. Interleukin-1alpha [50368] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50369] (1 PDB entry)

4. Interleukin-1beta [50363] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [50364] (25 PDB entries)
      Uniprot P01584 117-269

   2. Species Mouse (Mus musculus) [TaxId:10090] [50365] (2 PDB entries)

5. Interleukin-1F5 [101780] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [101781] (1 PDB entry)

6. automated matches [190999] (1 species)
   not a true protein

   • Species Human (Homo sapiens) [TaxId:9606] [188735] (17 PDB entries)

More info for Family b.42.1.2: Interleukin-1 (IL-1)

Timeline for Family b.42.1.2: Interleukin-1 (IL-1):

• Family b.42.1.2: Interleukin-1 (IL-1) first appeared (with stable ids) in SCOP 1.55
  
• Family b.42.1.2: Interleukin-1 (IL-1) appears in SCOPe 2.04
  
• Family b.42.1.2: Interleukin-1 (IL-1) appears in SCOPe 2.06
  
• Family b.42.1.2: Interleukin-1 (IL-1) appears in the current release, SCOPe 2.08