SCOP 1.75: Family b.40.4.3: Single strand DNA-binding domain, SSB

Lineage for Family b.40.4.3: Single strand DNA-binding domain, SSB

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.40: OB-fold [50198] (16 superfamilies)
   barrel, closed or partly opened n=5, S=10 or S=8; greek-key

4. Superfamily b.40.4: Nucleic acid-binding proteins [50249] (16 families)

5. Family b.40.4.3: Single strand DNA-binding domain, SSB [50263] (12 proteins)
   barrel, closed; n=5, S=10

Proteins:

1. Archaeal ssDNA-binding protein [89324] (1 species)
   similar to the domains of the Replication protein A

   • Species Archaeon Sulfolobus solfataricus [TaxId:2287] [89325] (1 PDB entry)

2. CDC13 ssDNA-binding domain [74948] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [74949] (2 PDB entries)

3. Core domain of telomere end binding protein beta subunit [50275] (1 species)

   • Species Oxytricha nova [TaxId:200597] [50276] (14 PDB entries)

4. Hypothetical protein At4g28440 (F20O9.120) [117193] (1 species)

   • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [117194] (1 PDB entry)
     Uniprot O49453 14-145

5. OB-fold domains of BRCA2 [82099] (2 species)
   duplication: tandem repeat of three OB-fold domains

   1. Species Mouse (Mus musculus) [TaxId:10090] [82100] (2 PDB entries)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [82101] (1 PDB entry)

6. Primosomal replication protein N, PriB [117191] (1 species)

   • Species Escherichia coli [TaxId:562] [117192] (3 PDB entries)
     Uniprot P07013

7. Protection of telomeres protein 1, Pot1 [101761] (2 species)

   1. Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [101762] (2 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [117190] (1 PDB entry)
      Uniprot Q9NUX5 6-299

8. Replication protein A 14 KDa (RPA14) subunit [50271] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50272] (5 PDB entries)

9. Replication protein A 32 KDa subunit (RPA32) fragment [50269] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50270] (5 PDB entries)

10. Replication protein A 70 KDa subunit (RPA70) [50267] (1 species)
    duplication: consists of three domains of this fold; contains zinc-finger insert in the C-terminal domain, residues 479-511

    • Species Human (Homo sapiens) [TaxId:9606] [50268] (6 PDB entries)

11. ssDNA-binding protein [50264] (4 species)

    1. Species Deinococcus radiodurans [TaxId:1299] [110194] (1 PDB entry)
       Uniprot Q9RY51

    2. Species Escherichia coli [TaxId:562] [50266] (5 PDB entries)
       Uniprot P02339

    3. Species Human (Homo sapiens), mitochondria [TaxId:9606] [50265] (3 PDB entries)
       Uniprot Q04837

    4. Species Mycobacterium tuberculosis [TaxId:1773] [101760] (4 PDB entries)

12. Telomere end binding protein alpha subunit [50273] (1 species)
    duplication: consists of three domains of this fold

    • Species Oxytricha nova [TaxId:200597] [50274] (16 PDB entries)

More info for Family b.40.4.3: Single strand DNA-binding domain, SSB

Timeline for Family b.40.4.3: Single strand DNA-binding domain, SSB:

• Family b.40.4.3: Single strand DNA-binding domain, SSB first appeared (with stable ids) in SCOP 1.55
  
• Family b.40.4.3: Single strand DNA-binding domain, SSB appears in SCOP 1.73
  
• Family b.40.4.3: Single strand DNA-binding domain, SSB appears in SCOPe 2.01
  
• Family b.40.4.3: Single strand DNA-binding domain, SSB appears in the current release, SCOPe 2.08