SCOPe 2.01: Family b.40.3.1: Tissue inhibitor of metalloproteinases, TIMP

Lineage for Family b.40.3.1: Tissue inhibitor of metalloproteinases, TIMP

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.40: OB-fold [50198] (16 superfamilies)
   barrel, closed or partly opened n=5, S=10 or S=8; greek-key

4. Superfamily b.40.3: TIMP-like [50242] (3 families)

5. Family b.40.3.1: Tissue inhibitor of metalloproteinases, TIMP [50243] (3 proteins)
   contains an irregular alpha+beta subdomain in the C-terminal extension

Proteins:

1. TIMP-1 [50244] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50245] (4 PDB entries)

2. TIMP-2 [50246] (2 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [50248] (2 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [50247] (3 PDB entries)

3. automated matches [190274] (2 species)
   not a true protein

   1. Species Cow (Bos taurus) [TaxId:9913] [187066] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [189382] (1 PDB entry)

More info for Family b.40.3.1: Tissue inhibitor of metalloproteinases, TIMP

Timeline for Family b.40.3.1: Tissue inhibitor of metalloproteinases, TIMP:

• Family b.40.3.1: Tissue inhibitor of metalloproteinases, TIMP first appeared (with stable ids) in SCOP 1.55
  
• Family b.40.3.1: Tissue inhibitor of metalloproteinases, TIMP appears in SCOP 1.75
  
• Family b.40.3.1: Tissue inhibitor of metalloproteinases, TIMP appears in SCOPe 2.02
  
• Family b.40.3.1: Tissue inhibitor of metalloproteinases, TIMP appears in the current release, SCOPe 2.08