SCOP 1.75: Family b.35.1.2: Alcohol dehydrogenase-like, N-terminal domain

Lineage for Family b.35.1.2: Alcohol dehydrogenase-like, N-terminal domain

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.35: GroES-like [50128] (2 superfamilies)
   contains barrel, partly opened; n*=4, S*=8; meander

4. Superfamily b.35.1: GroES-like [50129] (2 families)

5. Family b.35.1.2: Alcohol dehydrogenase-like, N-terminal domain [50136] (15 proteins)
   C-terminal domain is alpha/beta (classical Rossmann-fold)

Proteins:

1. 2,4-dienoyl-CoA reductase [89309] (1 species)

   • Species Yeast (Candida tropicalis) [TaxId:5482] [89310] (5 PDB entries)

2. Alcohol dehydrogenase [50137] (9 species)
   contains a Zn-finger subdomain, residues 94-117

   1. Species Archaeon Aeropyrum pernix [TaxId:56636] [101701] (1 PDB entry)

   2. Species Archaeon Sulfolobus solfataricus [TaxId:2287] [82080] (4 PDB entries)

   3. Species Bacillus stearothermophilus [TaxId:1422] [101703] (1 PDB entry)

   4. Species Cod (Gadus callarias) [TaxId:8053] [50141] (1 PDB entry)

   5. Species Frog (Rana perezi) [TaxId:8403] [89305] (2 PDB entries)

   6. Species Horse (Equus caballus) [TaxId:9796] [50138] (36 PDB entries)
      Uniprot P00327

   7. Species Human (Homo sapiens), different isozymes [TaxId:9606] [50139] (24 PDB entries)
      Uniprot P00326
      Uniprot P00325
      Uniprot P07327
      Uniprot P00326 ! Uniprot P00325 ! Uniprot P07327

   8. Species Mouse (Mus musculus), class II [TaxId:10090] [50140] (3 PDB entries)

   9. Species Pseudomonas aeruginosa [TaxId:287] [101702] (1 PDB entry)

3. B. subtilis YhfP homologue [117169] (1 species)

   • Species Bacillus stearothermophilus [TaxId:1422] [117170] (1 PDB entry)
     Uniprot Q5L022; 96% sequence identity; Geobacillus kaustophilus TaxID:1462

4. Bacterial secondary alcohol dehydrogenase [50142] (2 species)

   1. Species Clostridium beijerinckii [TaxId:1520] [50143] (3 PDB entries)

   2. Species Thermoanaerobacter brockii [TaxId:29323] [50144] (4 PDB entries)

5. Benzyl alcohol dehydrogenase [89306] (1 species)

   • Species Acinetobacter calcoaceticus [TaxId:471] [89307] (1 PDB entry)

6. Cinnamyl alcohol dehydrogenase, ADH6 [110173] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [110174] (3 PDB entries)
     Uniprot Q04894

7. Formaldehyde dehydrogenase [82081] (1 species)

   • Species Pseudomonas putida [TaxId:303] [82082] (1 PDB entry)

8. Hypothetical protein TM0436 [101704] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [101705] (1 PDB entry)

9. Hypothetical protein YahK [101708] (1 species)

   • Species Escherichia coli [TaxId:562] [101709] (1 PDB entry)

10. Hypothetical protein YhdH [101706] (1 species)

    • Species Escherichia coli [TaxId:562] [101707] (2 PDB entries)
      Uniprot P26646

11. Hypothetical protein YhfP [117171] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [117172] (2 PDB entries)
      Uniprot O07615

12. Ketose reductase (sorbitol dehydrogenase) [50145] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [101710] (3 PDB entries)

    2. Species Silverleaf whitefly (Bemisia argentifolii) [TaxId:77855] [50146] (1 PDB entry)

13. Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase [110175] (1 species)

    • Species Guinea pig (Cavia porcellus) [TaxId:10141] [110176] (4 PDB entries)
      Uniprot Q9EQZ5

14. Putative zinc-binding alcohol dehydrogenase [101711] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [101712] (1 PDB entry)

15. Quinone oxidoreductase [50147] (3 species)

    1. Species Escherichia coli [TaxId:562] [50148] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [117168] (1 PDB entry)
       Uniprot Q08257

    3. Species Thermus thermophilus [TaxId:274] [89308] (2 PDB entries)

More info for Family b.35.1.2: Alcohol dehydrogenase-like, N-terminal domain

Timeline for Family b.35.1.2: Alcohol dehydrogenase-like, N-terminal domain:

• Family b.35.1.2: Alcohol dehydrogenase-like, N-terminal domain first appeared (with stable ids) in SCOP 1.55
  
• Family b.35.1.2: Alcohol dehydrogenase-like, N-terminal domain appears in SCOP 1.73
  
• Family b.35.1.2: Alcohol dehydrogenase-like, N-terminal domain appears in SCOPe 2.01
  
• Family b.35.1.2: Alcohol dehydrogenase-like, N-terminal domain appears in the current release, SCOPe 2.08