SCOPe 2.06: Family b.34.2.1: SH3-domain

Lineage for Family b.34.2.1: SH3-domain

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.34: SH3-like barrel [50036] (21 superfamilies)
   barrel, partly opened; n*=4, S*=8; meander
   the last strand is interrupted by a turn of 3-10 helix

4. Superfamily b.34.2: SH3-domain [50044] (2 families)

5. Family b.34.2.1: SH3-domain [50045] (40 proteins)

Proteins:

1. 53BP2 [50078] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50079] (1 PDB entry)

2. Abl tyrosine kinase, SH3 domain [50052] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [50054] (6 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [50053] (3 PDB entries)

3. Actin binding protein ABP1 [74920] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [74921] (2 PDB entries)

4. alpha-Spectrin, SH3 domain [50058] (1 species)

   • Species Chicken (Gallus gallus) [TaxId:9031] [50059] (38 PDB entries)

5. Amphiphysin 2 [50080] (1 species)
   synonyms: Myc box dependent interacting protein 1, bin1

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [50081] (4 PDB entries)

6. BAI1-associated protein 2-like 1 (RIKEN cDNA 1300006m19) [110161] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [110162] (1 PDB entry)
     Uniprot Q9DBJ3 343-401

7. Bruton's tyrosine kinase [50068] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50069] (3 PDB entries)

8. BZZ1 [141188] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [141189] (1 PDB entry)
     Uniprot P38822 497-552

9. C-Crk, N-terminal SH3 domain [50046] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [50047] (8 PDB entries)

10. c-src protein tyrosine kinase [50064] (3 species)

    1. Species Avian sarcoma virus [TaxId:11876] [50067] (2 PDB entries)
       v-src

    2. Species Chicken (Gallus gallus) [TaxId:9031] [50066] (10 PDB entries)

    3. Species Human (Homo sapiens) [TaxId:9606] [50065] (6 PDB entries)

11. Carboxyl-terminal src kinase (csk) [74654] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [74658] (2 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [74655] (1 PDB entry)

12. EPS8 SH3 domain [50082] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [50083] (3 PDB entries)

13. Fyn proto-oncogene tyrosine kinase, SH3 domain [50048] (2 species)

    1. Species Chicken (Gallus gallus) [TaxId:9031] [256385] (2 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [50049] (16 PDB entries)

14. Fyn-binding protein (T-cell adapter protein adap) [101681] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101682] (1 PDB entry)

15. Grb2-related adaptor protein 2 (Mona/Gads) [89293] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [89294] (3 PDB entries)

16. Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains [50070] (3 species)

    1. Species Caenorhabditis elegans, SEM-5 [TaxId:6239] [50073] (5 PDB entries)
       Sex muscle abnormal protein 5

    2. Species Human (Homo sapiens) [TaxId:9606] [50071] (6 PDB entries)

    3. Species Mouse (Mus musculus) [TaxId:10090] [50072] (5 PDB entries)

17. Hemapoetic cell kinase Hck [50062] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50063] (26 PDB entries)

18. Hypothetical protein Baa76854.1 (KIAA1010) [101671] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101672] (2 PDB entries)

19. Hypothetical protein YFR024c [101679] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [101680] (1 PDB entry)

20. IL-2 inducible T-cell (Itc) kinase [50060] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [50061] (1 PDB entry)

21. Intersectin 2 (KIAA1256) [101669] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101670] (5 PDB entries)
      Uniprot Q9NZM3 761-841, 897-957, 982-1037, 1055-1121, 1102-1186

22. Kalirin-9a [117147] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117148] (1 PDB entry)
      Uniprot Q8BTT9 594-651

23. Melanoma inhibitory activity protein [63746] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63747] (4 PDB entries)

24. Nck-2 [159019] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [159020] (2 PDB entries)
      Uniprot O43639 192-262
      unclassified SH3 domains of this protein species are: 1WX6, 2B86, 2FRW, 2FRY

25. Olygophrenin-1 like protein (KIAA0621) [101673] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101674] (1 PDB entry)

26. p47pox (neutrophil cytosolic factor 1) [89295] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89296] (4 PDB entries)

27. p56-lck tyrosine kinase, SH3 domain [50076] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50077] (5 PDB entries)

28. p67phox [74922] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74923] (3 PDB entries)

29. Peroxisomal membrane protein Pex13p [82055] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82056] (3 PDB entries)

30. Phosphatidylinositol 3-kinase (p85-alpha subunit, pi3k), SH3 domain [50055] (2 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [50057] (2 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [50056] (3 PDB entries)

31. Phospholipase C, SH3 domain [50074] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50075] (2 PDB entries)

32. Psd-95 [69248] (1 species)
    associates with a guanylate kinase domain

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [69249] (3 PDB entries)

33. Rac/CDC42 GEF 6 [101677] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101678] (1 PDB entry)

34. RIM binding protein 2, RIMBP2 [117149] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [117150] (2 PDB entries)
      Uniprot O15034 160-242

35. SH3 domain from nebulin [50050] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50051] (2 PDB entries)

36. SH3-like domain of the L-type calcium channel [110158] (2 species)

    1. Species Norway rat (Rattus norvegicus) [TaxId:10116] [110160] (5 PDB entries)
       Uniprot P54287 38-362

    2. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [110159] (4 PDB entries)
       Uniprot P54288

37. Signal transducing adaptor molecule Stam2 [101675] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [101676] (1 PDB entry)

38. tyrosine kinase tec [69246] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [69247] (1 PDB entry)

39. Vav N-terminal SH3 domain [63744] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [63745] (3 PDB entries)

40. automated matches [190043] (6 species)
    not a true protein

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [186765] (4 PDB entries)

    2. Species Chicken (Gallus gallus) [TaxId:9031] [187080] (7 PDB entries)

    3. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [255023] (4 PDB entries)

    4. Species Human (Homo sapiens) [TaxId:9606] [187799] (30 PDB entries)

    5. Species Mouse (Mus musculus) [TaxId:10090] [187043] (7 PDB entries)

    6. Species Norway rat (Rattus norvegicus) [TaxId:10116] [187407] (8 PDB entries)

More info for Family b.34.2.1: SH3-domain

Timeline for Family b.34.2.1: SH3-domain:

• Family b.34.2.1: SH3-domain first appeared (with stable ids) in SCOP 1.55
  
• Family b.34.2.1: SH3-domain appears in SCOPe 2.05
  
• Family b.34.2.1: SH3-domain appears in SCOPe 2.07
  
• Family b.34.2.1: SH3-domain appears in the current release, SCOPe 2.08