SCOP 1.75: Superfamily b.26.1: SMAD/FHA domain

Lineage for Superfamily b.26.1: SMAD/FHA domain

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.26: SMAD/FHA domain [49878] (1 superfamily)
   sandwich; 11 strands in 2 sheets; greek-key

4. Superfamily b.26.1: SMAD/FHA domain [49879] (4 families)
   has a few short helices inserted in loops

Families:

1. b.26.1.1: SMAD domain [49880] (4 proteins)

2. b.26.1.2: FHA domain [49885] (11 proteins)

3. b.26.1.3: Interferon regulatory factor 3 (IRF3), transactivation domain [101630] (1 protein)
   weak sequence similarity to SMAD domain

4. b.26.1.4: EssC N-terminal domain-like [141143] (1 protein)
   PfamB PB051221 covers two consecutive domains; the first one is of canonical topology, whereas the second domain has a cirular permutation, beginnig at strand 2 and ending at strand 1 of the canonical fold

More info for Superfamily b.26.1: SMAD/FHA domain

Timeline for Superfamily b.26.1: SMAD/FHA domain:

• Superfamily b.26.1: SMAD/FHA domain first appeared (with stable ids) in SCOP 1.55
  
• Superfamily b.26.1: SMAD/FHA domain appears in SCOP 1.73
  
• Superfamily b.26.1: SMAD/FHA domain appears in SCOPe 2.01
  
• Superfamily b.26.1: SMAD/FHA domain appears in the current release, SCOPe 2.08