SCOPe 2.07: Family b.22.1.1: TNF-like

Lineage for Family b.22.1.1: TNF-like

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.22: TNF-like [49841] (1 superfamily)
   sandwich, 10 strands in 2 sheets; jelly-roll

4. Superfamily b.22.1: TNF-like [49842] (2 families)

5. Family b.22.1.1: TNF-like [49843] (15 proteins)

Proteins:

1. 30 kDa adipocyte complement-related protein [49846] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [49847] (2 PDB entries)

2. A proliferation-inducing ligand, APRIL [117117] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [117118] (5 PDB entries)
     Uniprot Q9D777 105-251 ! Uniprot Q9D777 105-241

3. Apoptosis-2 ligand, apo2l/TRAIL [49851] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49852] (5 PDB entries)

4. Collagen NC1 trimerisation domain [69230] (2 species)

   1. Species Human (Homo sapiens), isoform X [TaxId:9606] [69231] (1 PDB entry)

   2. Species Mouse (Mus musculus), isoform VIII [TaxId:10090] [101612] (1 PDB entry)

5. Complement c1q globular head, A chain [101613] (1 species)
   hetrotrimer of A, B and C chains

   • Species Human (Homo sapiens) [TaxId:9606] [101614] (6 PDB entries)

6. Complement c1q globular head, B chain [101615] (1 species)
   hetrotrimer of A, B and C chains

   • Species Human (Homo sapiens) [TaxId:9606] [101616] (3 PDB entries)

7. Complement c1q globular head, C chain [101617] (1 species)
   hetrotrimer of A, B and C chains

   • Species Human (Homo sapiens) [TaxId:9606] [101618] (5 PDB entries)

8. Ectodysplasin A, Eda-a1 [101610] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [101611] (2 PDB entries)

9. Extracellular domain of CD40 ligand [49844] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49845] (4 PDB entries)

10. Glucocorticoid-induced TNF-related ligand, TNFSF18 [158982] (4 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [158984] (6 PDB entries)
       Uniprot Q9UNG2 55-177! Uniprot Q9UNG2 57-172! Uniprot Q9UNG2 57-176

    2. Species Mouse (Mus musculus) [TaxId:10090] [158983] (4 PDB entries)
       Uniprot Q7TS55 51-173! Uniprot Q80YG2 49-173

    3. Species Ochotona princeps [TaxId:9978] [195782] (1 PDB entry)

    4. Species Otolemur garnettii [TaxId:30611] [194874] (1 PDB entry)

11. Soluble part of TALL-1, sTALL-1 (BAFF) [69228] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [69229] (8 PDB entries)
      also includes the PDB entry (1otz) that together with the entry (1p0t) provides the multimeric structure of the complex of this protein with its receptor, BAFF-R. In these entries protein chains are designated by both upper case and lower case letters creating problems with its processing and presentation in SCOP

12. TRANCE/RANKL cytokine [63721] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [63722] (6 PDB entries)

13. Tumor necrosis factor (TNF) [49848] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [49849] (33 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [49850] (3 PDB entries)

14. Tumor necrosis factor ligand superfamily member 4, OX40L [141127] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141128] (1 PDB entry)
       Uniprot P23510 58-183

    2. Species Mouse (Mus musculus) [TaxId:10090] [141129] (2 PDB entries)
       Uniprot P43488 58-185

15. automated matches [190204] (3 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [186956] (14 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [189134] (3 PDB entries)

    3. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [195809] (1 PDB entry)

More info for Family b.22.1.1: TNF-like

Timeline for Family b.22.1.1: TNF-like:

• Family b.22.1.1: TNF-like first appeared (with stable ids) in SCOP 1.55
  
• Family b.22.1.1: TNF-like appears in SCOPe 2.06
  
• Family b.22.1.1: TNF-like appears in the current release, SCOPe 2.08