SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2038038Fold b.7: C2 domain-like [49561] (5 superfamilies)
    sandwich; 8 strands in 2 sheets; greek-key
  4. 2038039Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families) (S)
    two constituent families are related by circular permutation

Families:

  1. 2038040b.7.1.1: PLC-like (P variant) [49563] (12 protein domains)
  2. 2038183b.7.1.2: Synaptotagmin-like (S variant) [49575] (11 protein domains)
    topologically similar to the C-terminal domain of PapD
  3. 2038265b.7.1.0: automated matches [191388] (1 protein)
    not a true family

More info for Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB)

Timeline for Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB):