SCOP 1.67: Family b.1.2.1: Fibronectin type III

Lineage for Family b.1.2.1: Fibronectin type III

1. Root: SCOP 1.67

2. Class b: All beta proteins [48724] (141 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (22 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.2: Fibronectin type III [49265] (1 family)

5. Family b.1.2.1: Fibronectin type III [49266] (22 proteins)

Proteins:

1. Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors [49289] (1 species)
   duplication: consists of four similar domains; dimerizes by swapping the C-terminal strands of domains 1 and 3

   • Species Human (Homo sapiens) [TaxId:9606] [49290] (3 PDB entries)

2. Cytokine receptor gp130 cytokine-binding domains [49295] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49296] (5 PDB entries)

3. Erythropoietin (EPO) receptor [49282] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49283] (5 PDB entries)

4. Extracellular region of human tissue factor [49267] (2 species)
   tandem of fibronectin type III domains

   1. Species Human (Homo sapiens) [TaxId:9606] [49268] (7 PDB entries)

   2. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [49269] (1 PDB entry)

5. Fibronectin type III domain from chitinase A1. [81975] (1 species)

   • Species Bacillus circulans [TaxId:1397] [81976] (1 PDB entry)

6. Fibronectin, different Fn3 modules [49270] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [49271] (9 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [49272] (2 PDB entries)

7. Granulocyte colony-stimulating factor (GC-SF) receptor [49291] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [49292] (4 PDB entries)

8. Growth hormone receptor [49280] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49281] (6 PDB entries)
     tandem of fibronectin type III domains

9. Integrin beta-4 subunit [49278] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49279] (1 PDB entry)

10. Interferon-alpha/beta receptor beta chain [89199] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89200] (2 PDB entries)

11. Interferon-gamma receptor alpha chain [49293] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49294] (3 PDB entries)

12. Interleukin-10 receptor 1, IL-10R1 [63670] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63671] (2 PDB entries)

13. Interleukin-4 receptor alpha chain [49287] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49288] (1 PDB entry)

14. Interleukin-6 receptor alpha chain, domains 2 and 3 [81977] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [81978] (2 PDB entries)

15. KIAA0343 protein [101531] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101532] (2 PDB entries)

16. KIAA1568 protein [101529] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101530] (2 PDB entries)

17. Neural cell adhesion molecule 1, NCAM [89197] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [89198] (1 PDB entry)

18. Neuroglian, two amino proximal Fn3 repeats [49276] (1 species)
    tandem of fibronectin type III domains

    • Species Drosophila melanogaster [TaxId:7227] [49277] (1 PDB entry)

19. Prolactin receptor [49284] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [49285] (1 PDB entry)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [49286] (1 PDB entry)

20. Tenascin [49273] (2 species)

    1. Species Chicken (Gallus gallus) [TaxId:9031] [49274] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [49275] (1 PDB entry)

21. The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3 [63672] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63673] (2 PDB entries)

22. Type I titin module [49297] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49298] (1 PDB entry)

More info for Family b.1.2.1: Fibronectin type III

Timeline for Family b.1.2.1: Fibronectin type III:

• Family b.1.2.1: Fibronectin type III first appeared (with stable ids) in SCOP 1.55
  
• Family b.1.2.1: Fibronectin type III appears in SCOP 1.65
  
• Family b.1.2.1: Fibronectin type III appears in SCOP 1.69
  
• Family b.1.2.1: Fibronectin type III appears in the current release, SCOPe 2.08