Lineage for Family b.1.2.1: Fibronectin type III

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2029371Superfamily b.1.2: Fibronectin type III [49265] (2 families) (S)
  5. 2029372Family b.1.2.1: Fibronectin type III [49266] (45 protein domains)
    Pfam PF00041

Protein Domains:

  1. 2029373Brother of CDO precursor (BOC) [141037] (1 species)
  2. 2029377Ciliary neurotrophic factor receptor alpha [110060] (1 species)
  3. 2029380Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors [49289] (1 species)
    duplication: consists of four similar domains; dimerizes by swapping the C-terminal strands of domains 1 and 3
  4. 2029401Contactin 3 (KIAA1496) [117055] (1 species)
  5. 2029404Cytokine receptor common gamma chain [141041] (1 species)
  6. 2029416Cytokine receptor gp130 cytokine-binding domains [49295] (1 species)
  7. 2029433Down syndrome cell adhesion molecule-like protein 1, DSCAML1 [141055] (1 species)
  8. 2029436Ephrin type-A receptor 1 [141063] (1 species)
  9. 2029439Ephrin type-A receptor 8 [141039] (1 species)
  10. 2029442Ephrin type-B receptor 1 [141035] (1 species)
  11. 2029445Erythropoietin (EPO) receptor [49282] (1 species)
  12. 2029473Extracellular region of human tissue factor [49267] (2 species)
    tandem of fibronectin type III domains
    1. 2029474Species Human (Homo sapiens) [TaxId:9606] [49268] (34 PDB entries)
      Uniprot P13726 33-242
    2. 2029546Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [49269] (1 PDB entry)
  13. 2029551Fibronectin type 3 and ankyrin repeat domains 1 protein, FANK1 [117053] (1 species)
  14. 2029554Fibronectin type III domain from chitinase A1. [81975] (1 species)
  15. 2029557Fibronectin type-III domain containing protein 3a, FNDC3A (KIAA0970) [117057] (1 species)
  16. 2029565Fibronectin, different Fn3 modules [49270] (3 species)
    1. 2029566Species Escherichia coli K-12 [TaxId:83333] [158899] (1 PDB entry)
    2. 2029568Species Human (Homo sapiens) [TaxId:9606] [49271] (9 PDB entries)
    3. 2029583Species Mouse (Mus musculus) [TaxId:10090] [49272] (2 PDB entries)
  17. 2029588Granulocyte colony-stimulating factor (GC-SF) receptor [49291] (2 species)
    1. 2029589Species Human (Homo sapiens) [TaxId:9606] [141034] (1 PDB entry)
      Uniprot Q99062 120-226! Uniprot Q99062 227-331
    2. 2029592Species Mouse (Mus musculus) [TaxId:10090] [49292] (4 PDB entries)
  18. 2029607Growth hormone receptor [49280] (1 species)
  19. 2029631Hedgehog receptor iHog [141061] (1 species)
    Cg9211-PA
  20. 2029645Host cell factor 2, HCF-2 [117051] (1 species)
  21. 2029648Insulin receptor [158901] (1 species)
  22. 2029653Integrin beta-4 subunit [49278] (1 species)
  23. 2029664Interferon-alpha/beta receptor beta chain [89199] (1 species)
  24. 2029676Interferon-gamma receptor alpha chain [49293] (1 species)
  25. 2029689Interleukin-10 receptor 1, IL-10R1 [63670] (1 species)
  26. 2029703Interleukin-2 receptor beta chain [141047] (1 species)
  27. 2029713Interleukin-4 receptor alpha chain [49287] (1 species)
  28. 2029717Interleukin-6 receptor alpha chain, domains 2 and 3 [81977] (1 species)
  29. 2029723KIAA0343 protein [101531] (1 species)
  30. 2029727KIAA1355 [110058] (1 species)
  31. 2029730KIAA1568 protein [101529] (1 species)
  32. 2029734Myosin binding protein C, fast-type [141057] (1 species)
  33. 2029737Neogenin [141053] (1 species)
  34. 2029745Neural cell adhesion molecule 1, NCAM [89197] (2 species)
    1. 2029746Species Human (Homo sapiens) [TaxId:9606] [141033] (4 PDB entries)
      Uniprot P13592 498-598
    2. 2029767Species Norway rat (Rattus norvegicus) [TaxId:10116] [89198] (1 PDB entry)
  35. 2029769Neuroglian, two amino proximal Fn3 repeats [49276] (1 species)
    tandem of fibronectin type III domains
  36. 2029773Prolactin receptor [49284] (2 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [49285] (1 PDB entry)
    2. 2029777Species Norway rat (Rattus norvegicus) [TaxId:10116] [49286] (1 PDB entry)
  37. 2029782Receptor-type tyrosine-protein phosphatase delta, PTPRD [141049] (1 species)
  38. 2029786Receptor-type tyrosine-protein phosphatase F, PTPRF [141059] (1 species)
  39. 2029789Rim binding protein 2 [141043] (1 species)
  40. 2029792Sidekick 2 [141051] (1 species)
  41. 2029798Tenascin [49273] (3 species)
    1. 2029799Species Chicken (Gallus gallus) [TaxId:9031] [49274] (1 PDB entry)
    2. 2029804Species Human (Homo sapiens) [TaxId:9606] [49275] (1 PDB entry)
    3. 2029806Species Norway rat (Rattus norvegicus) [TaxId:10116] [110057] (1 PDB entry)
      Uniprot Q05546 502-770
  42. 2029810Tenascin-X [141045] (1 species)
  43. 2029815The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3 [63672] (1 species)
  44. 2029831Type I titin module [49297] (1 species)
  45. 2029834automated matches [190888] (1 species)
    not a true protein

More info for Family b.1.2.1: Fibronectin type III

Timeline for Family b.1.2.1: Fibronectin type III: