SCOPe 2.06: Family b.1.1.4: I set domains

Lineage for Family b.1.1.4: I set domains

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.4: I set domains [49159] (39 proteins)

Proteins:

1. Axonin-1 [49184] (1 species)
   tandem repeat of 4 L1 domains

   • Species Chicken (Gallus gallus) [TaxId:9031] [49185] (1 PDB entry)

2. B and T lymphocyte attenuator, Btla [117041] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [117042] (1 PDB entry)
     Uniprot Q7TSA3 40-143

3. Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), C-terminal domain [81956] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [81957] (1 PDB entry)

4. Cardiac myosin binding protein C, different domains [89185] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89186] (5 PDB entries)
     Uniprot Q14896 358-451, 641-770

5. CD3 delta chain ectodomain fragment [117043] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117044] (1 PDB entry)
     Uniprot P04234 23-95

6. CD3 epsilon chain ectodomain fragment [69162] (3 species)
   possibly an intermediate structure between the I set and FnIII domains

   1. Species Human (Homo sapiens) [TaxId:9606] [110051] (2 PDB entries)
      Uniprot P07766 33-123 ! Uniprot P07766 # CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain precursor

   2. Species Mouse (Mus musculus) [TaxId:10090] [69163] (2 PDB entries)
      Uniprot P22646 22-100

   3. Species Sheep (Ovis aries) [TaxId:9940] [117040] (1 PDB entry)
      Uniprot P18438 22-88

7. CD3 gamma chain ectodomain fragment [69160] (2 species)
   possibly an intermediate structure between the I set and FnIII domains

   1. Species Human (Homo sapiens) [TaxId:9606] [110050] (1 PDB entry)
      Uniprot P09693 # CD3G_HUMAN T-cell surface glycoprotein CD3 gamma chain precursor

   2. Species Mouse (Mus musculus) [TaxId:10090] [69161] (1 PDB entry)

8. Cervical EMMPRIN [158877] (1 species)
   contains two Ig-domains in the N-terminal part

   • Species Human (Homo sapiens) [TaxId:9606] [158878] (1 PDB entry)
     Uniprot Q54A51 103-203! Uniprot Q54A51 23-102

9. Fc gamma receptor ectodomain (CD32) [49196] (3 species)
   possibly an intermediate structure between the I set and FnIII domains

   1. Species Human (Homo sapiens), IIa [TaxId:9606] [49197] (2 PDB entries)

   2. Species Human (Homo sapiens), IIb [TaxId:9606] [49198] (1 PDB entry)

   3. Species Human (Homo sapiens), III [TaxId:9606] [49199] (5 PDB entries)
      Uniprot O75015 23-189

10. Fibroblast growth factor receptor, FGFR [49179] (4 species)

    1. Species Human (Homo sapiens), FGFR1 [TaxId:9606] [49180] (3 PDB entries)

    2. Species Human (Homo sapiens), FGFR2a [TaxId:9606] [49181] (11 PDB entries)

    3. Species Human (Homo sapiens), FGFR2b [TaxId:9606] [81955] (1 PDB entry)

    4. Species Human (Homo sapiens), FGFR3c [TaxId:9606] [101514] (1 PDB entry)

11. Hemolin [49182] (1 species)
    Duplication: tandem repeat of 4 domains, known as L1 domains

    • Species Moth (Hyalophora cecropia) [TaxId:7123] [49183] (1 PDB entry)

12. High affinity nerve growth factor receptor TrkA, different domains [49190] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49191] (4 PDB entries)

13. Ig alpha Fc receptor, FCARI (CD89) [89188] (1 species)
    possibly an intermediate structure between the I set and FnIII domains

    • Species Human (Homo sapiens) [TaxId:9606] [89189] (3 PDB entries)

14. IgE high affinity receptor alpha subunit [49200] (1 species)
    possibly an intermediate structure between the I set and FnIII domains

    • Species Human (Homo sapiens) [TaxId:9606] [49201] (7 PDB entries)
      Uniprot P12319 29-196

15. Intercellular adhesion molecule-1, ICAM-1 [49162] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49163] (6 PDB entries)

16. Intercellular adhesion molecule-2, ICAM-2 [49164] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49165] (1 PDB entry)

17. Interleukin-6 receptor alpha chain, N-terminal domain [81958] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [81959] (1 PDB entry)

18. Junction adhesion molecule, JAM, C-terminal domain [49186] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [89187] (1 PDB entry)

    2. Species Mouse (Mus musculus) [TaxId:10090] [49187] (1 PDB entry)

19. Killer cell inhibitory receptor [49202] (4 species)
    possibly an intermediate structure between the I set and FnIII domains

    1. Species Human (Homo sapiens), 2dl2 [TaxId:9606] [49205] (2 PDB entries)

    2. Species Human (Homo sapiens), kir2dl3 [TaxId:9606] [49203] (2 PDB entries)

    3. Species Human (Homo sapiens), kir2ds3, CD158j [TaxId:9606] [89190] (1 PDB entry)

    4. Species Human (Homo sapiens), p58-cl42 kir [TaxId:9606] [49204] (2 PDB entries)

20. Ligand binding domain of lir-1 (ilt2) [49206] (1 species)
    possibly an intermediate structure between the I set and FnIII domains

    • Species Human (Homo sapiens) [TaxId:9606] [49207] (5 PDB entries)
      Uniprot Q8NHL6 25-218

21. Ligand binding domain of lir-2 (ilt4) [158879] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [158880] (1 PDB entry)
      Uniprot Q8N423 120-218! Uniprot Q8N423 26-109

22. Ligand binding domain of NK receptor NKp46 [101519] (1 species)
    possibly an intermediate structure between the I set and FnIII domains

    • Species Human (Homo sapiens) [TaxId:9606] [101520] (2 PDB entries)

23. Ligand binding domain of trkB receptor [49192] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49193] (2 PDB entries)

24. Mucosal addressin cell adhesion molecule-1 (MADCAM-1) [49168] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49169] (2 PDB entries)

25. Myosin-binding protein C, slow-type [141013] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141014] (2 PDB entries)
      Uniprot Q00872 342-431! Uniprot Q00872 58-170

26. Neural cell adhesion molecule (NCAM) [49166] (2 species)

    1. Species Chicken (Gallus gallus) [TaxId:9031] [63664] (1 PDB entry)

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [49167] (4 PDB entries)
       Rat and mouse sequences are identical for the two N-terminal modules

27. NT3 binding domain of trkC receptor [49194] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49195] (1 PDB entry)

28. Perlecan Ig3 domain [69158] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [69159] (1 PDB entry)

29. Receptor-type tyrosine-protein phosphatase mu [141015] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141016] (1 PDB entry)
      Uniprot P28827 184-279

30. Second domain of the Flt-1 receptor [49188] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49189] (6 PDB entries)

31. Semaphorin 4d Ig-like domain [101515] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101516] (2 PDB entries)

32. Telokin [49170] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141012] (1 PDB entry)
       Uniprot Q9UIT9 1238-1338

    2. Species Turkey (Meleagris gallopavo) [TaxId:9103] [49171] (2 PDB entries)

33. The p40 domain of interleukin-12 (IL-12 beta chain), N-terminal domain [63665] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63666] (5 PDB entries)

34. Titin [49172] (1 species)

    • Species Human (Homo sapiens), different modules [TaxId:9606] [49173] (7 PDB entries)

35. Twitchin [49174] (2 species)

    1. Species Human (Homo sapiens), Ig repeat 27 [TaxId:9606] [49176] (2 PDB entries)

    2. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [49175] (3 PDB entries)
       different modules

36. Type-1 interleukin-1 receptor [49177] (1 species)
    duplication: tandem repeat of 3 domains

    • Species Human (Homo sapiens) [TaxId:9606] [49178] (4 PDB entries)

37. Tyrosine-protein kinase receptor tyro3, second domain [101517] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101518] (1 PDB entry)

38. Vascular cell adhesion molecule-1 (VCAM-1) [49160] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49161] (3 PDB entries)

39. automated matches [190803] (2 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [188070] (30 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [256051] (1 PDB entry)

More info for Family b.1.1.4: I set domains

Timeline for Family b.1.1.4: I set domains:

• Family b.1.1.4: I set domains first appeared (with stable ids) in SCOP 1.55
  
• Family b.1.1.4: I set domains appears in SCOPe 2.05
  
• Family b.1.1.4: I set domains appears in SCOPe 2.07
  
• Family b.1.1.4: I set domains appears in the current release, SCOPe 2.08