Lineage for Family b.1.1.4: I set domains

  1. Root: SCOP 1.75
  2. 781541Class b: All beta proteins [48724] (174 folds)
  3. 781542Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 781543Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 787055Family b.1.1.4: I set domains [49159] (38 proteins)

Proteins:

  1. 787056Axonin-1 [49184] (1 species)
    tandem repeat of 4 L1 domains
  2. 787062B and T lymphocyte attenuator, Btla [117041] (1 species)
  3. 787065Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), C-terminal domain [81956] (1 species)
  4. 787068Cardiac myosin binding protein C, different domains [89185] (1 species)
  5. 787073CD3 delta chain ectodomain fragment [117043] (1 species)
  6. 787077CD3 epsilon chain ectodomain fragment [69162] (3 species)
    possibly an intermediate structure between the I set and FnIII domains
    1. 787078Species Human (Homo sapiens) [TaxId:9606] [110051] (2 PDB entries)
      Uniprot P07766 33-123
      Uniprot P07766 # CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain precursor
      Uniprot P07766 33-123 ! Uniprot P07766 # CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain precursor
    2. 787082Species Mouse (Mus musculus) [TaxId:10090] [69163] (2 PDB entries)
      Uniprot P22646 22-100
    3. 787085Species Sheep (Ovis aries) [TaxId:9940] [117040] (1 PDB entry)
      Uniprot P18438 22-88
  7. 787087CD3 gamma chain ectodomain fragment [69160] (2 species)
    possibly an intermediate structure between the I set and FnIII domains
    1. 787088Species Human (Homo sapiens) [TaxId:9606] [110050] (1 PDB entry)
      Uniprot P09693 # CD3G_HUMAN T-cell surface glycoprotein CD3 gamma chain precursor
    2. 787090Species Mouse (Mus musculus) [TaxId:10090] [69161] (1 PDB entry)
  8. 787092Cervical EMMPRIN [158877] (1 species)
    contains two Ig-domains in the N-terminal part
  9. 787102Fc gamma receptor ectodomain (CD32) [49196] (3 species)
    possibly an intermediate structure between the I set and FnIII domains
    1. 787103Species Human (Homo sapiens), IIa [TaxId:9606] [49197] (2 PDB entries)
    2. 787108Species Human (Homo sapiens), IIb [TaxId:9606] [49198] (1 PDB entry)
    3. 787111Species Human (Homo sapiens), III [TaxId:9606] [49199] (5 PDB entries)
      Uniprot O75015 23-189
  10. 787122Fibroblast growth factor receptor, FGFR [49179] (4 species)
    1. 787123Species Human (Homo sapiens), FGFR1 [TaxId:9606] [49180] (4 PDB entries)
    2. 787140Species Human (Homo sapiens), FGFR2a [TaxId:9606] [49181] (7 PDB entries)
    3. 787174Species Human (Homo sapiens), FGFR2b [TaxId:9606] [81955] (1 PDB entry)
    4. 787177Species Human (Homo sapiens), FGFR3c [TaxId:9606] [101514] (1 PDB entry)
  11. 787180Hemolin [49182] (1 species)
    Duplication: tandem repeat of 4 domains, known as L1 domains
  12. 787190High affinity nerve growth factor receptor TrkA, different domains [49190] (1 species)
  13. 787201Ig alpha Fc receptor, FCARI (CD89) [89188] (1 species)
    possibly an intermediate structure between the I set and FnIII domains
  14. 787213IgE high affinity receptor alpha subunit [49200] (1 species)
    possibly an intermediate structure between the I set and FnIII domains
  15. 787253Intercellular adhesion molecule-1, ICAM-1 [49162] (1 species)
  16. 787270Intercellular adhesion molecule-2, ICAM-2 [49164] (1 species)
  17. 787273Interleukin-6 receptor alpha chain, N-terminal domain [81958] (1 species)
  18. 787276Junction adhesion molecule, JAM, C-terminal domain [49186] (2 species)
    1. 787277Species Human (Homo sapiens) [TaxId:9606] [89187] (1 PDB entry)
    2. 787280Species Mouse (Mus musculus) [TaxId:10090] [49187] (1 PDB entry)
  19. 787282Killer cell inhibitory receptor [49202] (4 species)
    possibly an intermediate structure between the I set and FnIII domains
    1. 787283Species Human (Homo sapiens), 2dl2 [TaxId:9606] [49205] (2 PDB entries)
    2. 787288Species Human (Homo sapiens), kir2dl3 [TaxId:9606] [49203] (2 PDB entries)
    3. 787295Species Human (Homo sapiens), kir2ds3, CD158j [TaxId:9606] [89190] (1 PDB entry)
    4. 787298Species Human (Homo sapiens), p58-cl42 kir [TaxId:9606] [49204] (2 PDB entries)
  20. 787303Ligand binding domain of lir-1 (ilt2) [49206] (1 species)
    possibly an intermediate structure between the I set and FnIII domains
  21. 787317Ligand binding domain of lir-2 (ilt4) [158879] (1 species)
  22. 787321Ligand binding domain of NK receptor NKp46 [101519] (1 species)
    possibly an intermediate structure between the I set and FnIII domains
  23. 787327Ligand binding domain of trkB receptor [49192] (1 species)
  24. 787332Mucosal addressin cell adhesion molecule-1 (MADCAM-1) [49168] (1 species)
  25. 787338Myosin-binding protein C, slow-type [141013] (1 species)
  26. 787342Neural cell adhesion molecule (NCAM) [49166] (2 species)
    1. 787343Species Chicken (Gallus gallus) [TaxId:9031] [63664] (1 PDB entry)
    2. 787345Species Rat (Rattus norvegicus) [TaxId:10116] [49167] (4 PDB entries)
      Rat and mouse sequences are identical for the two N-terminal modules
  27. 787359NT3 binding domain of trkC receptor [49194] (1 species)
  28. 787362Perlecan Ig3 domain [69158] (1 species)
  29. 787365Receptor-type tyrosine-protein phosphatase mu [141015] (1 species)
  30. 787368Second domain of the Flt-1 receptor [49188] (1 species)
  31. 787380Semaphorin 4d Ig-like domain [101515] (1 species)
  32. 787384Telokin [49170] (2 species)
    1. 787385Species Human (Homo sapiens) [TaxId:9606] [141012] (1 PDB entry)
      Uniprot Q9UIT9 1238-1338
    2. 787387Species Turkey (Meleagris gallopavo) [TaxId:9103] [49171] (2 PDB entries)
  33. 787390The p40 domain of interleukin-12 (IL-12 beta chain), N-terminal domain [63665] (1 species)
  34. 787399Titin [49172] (1 species)
  35. 787407Twitchin [49174] (2 species)
    1. 787408Species Human (Homo sapiens), Ig repeat 27 [TaxId:9606] [49176] (2 PDB entries)
    2. 787411Species Nematode (Caenorhabditis elegans) [TaxId:6239] [49175] (3 PDB entries)
      different modules
  36. 787415Type-1 interleukin-1 receptor [49177] (1 species)
    duplication: tandem repeat of 3 domains
  37. 787426Tyrosine-protein kinase receptor tyro3, second domain [101517] (1 species)
  38. 787430Vascular cell adhesion molecule-1 (VCAM-1) [49160] (1 species)

More info for Family b.1.1.4: I set domains

Timeline for Family b.1.1.4: I set domains: