Lineage for Family b.1.1.4: I set domains

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2026186Family b.1.1.4: I set domains [49159] (39 protein domains)

Protein Domains:

  1. 2026187Axonin-1 [49184] (1 species)
    tandem repeat of 4 L1 domains
  2. 2026193B and T lymphocyte attenuator, Btla [117041] (1 species)
  3. 2026196Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), C-terminal domain [81956] (1 species)
  4. 2026199Cardiac myosin binding protein C, different domains [89185] (1 species)
  5. 2026206CD3 delta chain ectodomain fragment [117043] (1 species)
  6. 2026210CD3 epsilon chain ectodomain fragment [69162] (3 species)
    possibly an intermediate structure between the I set and FnIII domains
    1. 2026211Species Human (Homo sapiens) [TaxId:9606] [110051] (2 PDB entries)
      Uniprot P07766 33-123 ! Uniprot P07766 # CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain precursor
    2. 2026215Species Mouse (Mus musculus) [TaxId:10090] [69163] (2 PDB entries)
      Uniprot P22646 22-100
    3. 2026218Species Sheep (Ovis aries) [TaxId:9940] [117040] (1 PDB entry)
      Uniprot P18438 22-88
  7. 2026220CD3 gamma chain ectodomain fragment [69160] (2 species)
    possibly an intermediate structure between the I set and FnIII domains
    1. 2026221Species Human (Homo sapiens) [TaxId:9606] [110050] (1 PDB entry)
      Uniprot P09693 # CD3G_HUMAN T-cell surface glycoprotein CD3 gamma chain precursor
    2. 2026223Species Mouse (Mus musculus) [TaxId:10090] [69161] (1 PDB entry)
  8. 2026225Cervical EMMPRIN [158877] (1 species)
    contains two Ig-domains in the N-terminal part
  9. 2026235Fc gamma receptor ectodomain (CD32) [49196] (3 species)
    possibly an intermediate structure between the I set and FnIII domains
    1. 2026236Species Human (Homo sapiens), IIa [TaxId:9606] [49197] (2 PDB entries)
    2. 2026241Species Human (Homo sapiens), IIb [TaxId:9606] [49198] (1 PDB entry)
    3. 2026244Species Human (Homo sapiens), III [TaxId:9606] [49199] (5 PDB entries)
      Uniprot O75015 23-189
  10. 2026255Fibroblast growth factor receptor, FGFR [49179] (4 species)
    1. Species Human (Homo sapiens), FGFR1 [TaxId:9606] [49180] (3 PDB entries)
    2. 2026269Species Human (Homo sapiens), FGFR2a [TaxId:9606] [49181] (11 PDB entries)
    3. 2026313Species Human (Homo sapiens), FGFR2b [TaxId:9606] [81955] (1 PDB entry)
    4. 2026316Species Human (Homo sapiens), FGFR3c [TaxId:9606] [101514] (1 PDB entry)
  11. 2026319Hemolin [49182] (1 species)
    Duplication: tandem repeat of 4 domains, known as L1 domains
  12. 2026329High affinity nerve growth factor receptor TrkA, different domains [49190] (1 species)
  13. 2026340Ig alpha Fc receptor, FCARI (CD89) [89188] (1 species)
    possibly an intermediate structure between the I set and FnIII domains
  14. 2026352IgE high affinity receptor alpha subunit [49200] (1 species)
    possibly an intermediate structure between the I set and FnIII domains
  15. 2026392Intercellular adhesion molecule-1, ICAM-1 [49162] (1 species)
  16. 2026407Intercellular adhesion molecule-2, ICAM-2 [49164] (1 species)
  17. 2026410Interleukin-6 receptor alpha chain, N-terminal domain [81958] (1 species)
  18. 2026413Junction adhesion molecule, JAM, C-terminal domain [49186] (2 species)
    1. 2026414Species Human (Homo sapiens) [TaxId:9606] [89187] (1 PDB entry)
    2. 2026417Species Mouse (Mus musculus) [TaxId:10090] [49187] (1 PDB entry)
  19. 2026419Killer cell inhibitory receptor [49202] (4 species)
    possibly an intermediate structure between the I set and FnIII domains
    1. 2026420Species Human (Homo sapiens), 2dl2 [TaxId:9606] [49205] (2 PDB entries)
    2. 2026425Species Human (Homo sapiens), kir2dl3 [TaxId:9606] [49203] (2 PDB entries)
    3. 2026432Species Human (Homo sapiens), kir2ds3, CD158j [TaxId:9606] [89190] (1 PDB entry)
    4. 2026435Species Human (Homo sapiens), p58-cl42 kir [TaxId:9606] [49204] (2 PDB entries)
  20. 2026440Ligand binding domain of lir-1 (ilt2) [49206] (1 species)
    possibly an intermediate structure between the I set and FnIII domains
  21. 2026454Ligand binding domain of lir-2 (ilt4) [158879] (1 species)
  22. 2026458Ligand binding domain of NK receptor NKp46 [101519] (1 species)
    possibly an intermediate structure between the I set and FnIII domains
  23. 2026464Ligand binding domain of trkB receptor [49192] (1 species)
  24. 2026469Mucosal addressin cell adhesion molecule-1 (MADCAM-1) [49168] (1 species)
  25. 2026475Myosin-binding protein C, slow-type [141013] (1 species)
  26. 2026479Neural cell adhesion molecule (NCAM) [49166] (2 species)
    1. 2026480Species Chicken (Gallus gallus) [TaxId:9031] [63664] (1 PDB entry)
    2. 2026482Species Norway rat (Rattus norvegicus) [TaxId:10116] [49167] (4 PDB entries)
      Rat and mouse sequences are identical for the two N-terminal modules
  27. 2026496NT3 binding domain of trkC receptor [49194] (1 species)
  28. 2026499Perlecan Ig3 domain [69158] (1 species)
  29. 2026502Receptor-type tyrosine-protein phosphatase mu [141015] (1 species)
  30. 2026505Second domain of the Flt-1 receptor [49188] (1 species)
  31. 2026517Semaphorin 4d Ig-like domain [101515] (1 species)
  32. 2026522Telokin [49170] (2 species)
    1. 2026523Species Human (Homo sapiens) [TaxId:9606] [141012] (1 PDB entry)
      Uniprot Q9UIT9 1238-1338
    2. 2026525Species Turkey (Meleagris gallopavo) [TaxId:9103] [49171] (2 PDB entries)
  33. 2026528The p40 domain of interleukin-12 (IL-12 beta chain), N-terminal domain [63665] (1 species)
  34. 2026537Titin [49172] (1 species)
  35. 2026549Twitchin [49174] (2 species)
    1. 2026550Species Human (Homo sapiens), Ig repeat 27 [TaxId:9606] [49176] (2 PDB entries)
    2. 2026553Species Nematode (Caenorhabditis elegans) [TaxId:6239] [49175] (3 PDB entries)
      different modules
  36. 2026557Type-1 interleukin-1 receptor [49177] (1 species)
    duplication: tandem repeat of 3 domains
  37. 2026571Tyrosine-protein kinase receptor tyro3, second domain [101517] (1 species)
  38. 2026575Vascular cell adhesion molecule-1 (VCAM-1) [49160] (1 species)
  39. 2026582automated matches [190803] (2 species)
    not a true protein
    1. 2026583Species Human (Homo sapiens) [TaxId:9606] [188070] (30 PDB entries)
    2. 2026641Species Mouse (Mus musculus) [TaxId:10090] [256051] (1 PDB entry)

More info for Family b.1.1.4: I set domains

Timeline for Family b.1.1.4: I set domains: