Lineage for Family b.1.1.2: C1 set domains (antibody constant domain-like)

  1. Root: SCOPe 2.05
  2. 1755445Class b: All beta proteins [48724] (176 folds)
  3. 1755446Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 1755447Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 1758822Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 protein domains)

Protein Domains:

  1. 1758823beta2-microglobulin [88600] (5 species)
    1. 1758824Species Cow (Bos taurus) [TaxId:9913] [48946] (6 PDB entries)
    2. 1758835Species Human (Homo sapiens) [TaxId:9606] [88602] (388 PDB entries)
      Uniprot P61769 21-119 ! Uniprot P01884
    3. 1759459Species Mouse (Mus musculus) [TaxId:10090] [88603] (174 PDB entries)
      Uniprot P01887
    4. 1759731Species Norway rat (Rattus norvegicus) [TaxId:10116] [88601] (6 PDB entries)
    5. 1759741Species Pig (Sus scrofa) [TaxId:9823] [189845] (2 PDB entries)
  2. 1759745CD1, alpha-3 domain [88615] (5 species)
    1. 1759746Species Cow (Bos taurus) [TaxId:9913] [226527] (2 PDB entries)
    2. 1759750Species Human (Homo sapiens), CD1a [TaxId:9606] [101513] (5 PDB entries)
    3. 1759760Species Human (Homo sapiens), CD1b [TaxId:9606] [88617] (10 PDB entries)
    4. 1759773Species Human (Homo sapiens), CD1d [TaxId:9606] [158876] (2 PDB entries)
      Uniprot P15813 202-295
    5. 1759777Species Mouse (Mus musculus) [TaxId:10090] [88616] (9 PDB entries)
  3. 1759790Class I MHC homolog, alpha-3 domain [88610] (4 species)
    gamma, delta T-cell ligand
    1. 1759791Species Human (Homo sapiens), Mic-a [TaxId:9606] [48968] (2 PDB entries)
    2. 1759794Species Human (Homo sapiens), Mic-b [TaxId:9606] [74826] (1 PDB entry)
    3. 1759796Species Mouse (Mus musculus), t10 [TaxId:10090] [101512] (1 PDB entry)
    4. 1759801Species Mouse (Mus musculus), t22 [TaxId:10090] [88611] (2 PDB entries)
  4. 1759808Class I MHC, alpha-3 domain [88604] (4 species)
    1. 1759809Species Human (Homo sapiens) [TaxId:9606] [88605] (189 PDB entries)
      Uniprot P30685 25-300 ! Uniprot P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor ! Uniprot P30481 25-300 ! Uniprot P01892 25-298 ! Uniprot P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
    2. 1760095Species Mouse (Mus musculus) [TaxId:10090] [88606] (103 PDB entries)
      Uniprot P01901 22-299
    3. 1760272Species Norway rat (Rattus norvegicus), RT1-AA [TaxId:10116] [88607] (3 PDB entries)
    4. 1760277Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [158875] (1 PDB entry)
  5. 1760280Class II MHC alpha chain, C-terminal domain [88618] (6 species)
    1. 1760281Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88619] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 1760283Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88623] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 1760288Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88621] (37 PDB entries)
      Uniprot P01903 28-207
      probably orthologous to the mouse I-E group
    4. 1760344Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88620] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 1760346Species Mouse (Mus musculus), I-A group [TaxId:10090] [88624] (25 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 1760386Species Mouse (Mus musculus), I-E group [TaxId:10090] [88622] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  6. 1760407Class II MHC beta chain, C-terminal domain [88625] (6 species)
    1. 1760408Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88626] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 1760410Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88630] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 1760415Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88628] (40 PDB entries)
      Uniprot P04229 30-219
      probably orthologous to the mouse I-E group
    4. 1760476Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88627] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 1760478Species Mouse (Mus musculus), I-A group [TaxId:10090] [88631] (17 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 1760505Species Mouse (Mus musculus), I-E group [TaxId:10090] [88629] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  7. 1760526Fc (IgG) receptor, alpha-3 domain [88612] (2 species)
    1. 1760527Species Human (Homo sapiens) [TaxId:9606] [88614] (1 PDB entry)
    2. 1760529Species Norway rat (Rattus norvegicus) [TaxId:10116] [88613] (3 PDB entries)
  8. 1760535Hemochromatosis protein Hfe, alpha-3 domain [88608] (1 species)
  9. 1760542Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580] (1 species)
  10. 1760547Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181] (1 species)
  11. 1760553Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183] (1 species)
  12. 1760559Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594] (1 species)
  13. 1760564Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596] (1 species)
  14. 1760571Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598] (1 species)
  15. 1760578Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
    1. 1760579Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88579] (1 PDB entry)
    2. 1760582Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
    3. 1760894Species Mouse (Mus musculus) [TaxId:10090] [88576] (415 PDB entries)
      Uniprot P01864 # GCAB_MOUSE Ig gamma-2A chain C region secreted form (B allele) ! Uniprot P01863 #GCAA_MOUSE Ig gamma-2A chain C region, A allele; 86% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01751 (Ig heavy chain V region B1-8/186-2) and Uniprot P01864 (Ig gamma-2A chain C region secreted form) ! Uniprot P01868 # GC1_MOUSE Ig gamma-1 chain C region secreted form ! Uniprot P01864 # GCAB_MOUSE (P01864) Ig gamma-2A chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! Uniprot P01863 # GCAA_MOUSE Ig gamma-2A chain C region, A allele ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01868 # ! GC1_MOUSE Ig gamma-1 chain C region secreted form
    4. 1761437Species Mouse (Mus musculus), gamma3 [TaxId:10090] [88577] (8 PDB entries)
      Uniprot P22436 # GC3_MOUSE (P22436) Ig gamma-3 chain C region
    5. 1761451Species Norway rat (Rattus norvegicus) [TaxId:10116] [88578] (5 PDB entries)
    6. 1761464Species Synthetic construct [TaxId:32630] [158874] (1 PDB entry)
  16. 1761466Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species)
    1. 1761467Species Human (Homo sapiens) [TaxId:9606] [88585] (41 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    2. 1761546Species Mouse (Mus musculus) [TaxId:10090] [88586] (1 PDB entry)
    3. 1761549Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88587] (1 PDB entry)
    4. 1761552Species Norway rat (Rattus norvegicus) [TaxId:10116] [88588] (3 PDB entries)
  17. 1761558Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589] (5 species)
    1. 1761559Species Guinea pig (Cavia porcellus) [TaxId:10141] [49123] (1 PDB entry)
    2. 1761561Species Human (Homo sapiens) [TaxId:9606] [88590] (49 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    3. 1761659Species Mouse (Mus musculus) [TaxId:10090] [88591] (2 PDB entries)
    4. 1761664Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88592] (1 PDB entry)
    5. 1761667Species Norway rat (Rattus norvegicus) [TaxId:10116] [88593] (3 PDB entries)
  18. 1761673Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582] (1 species)
  19. 1761687Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)
    1. 1761688Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody
    2. 1761919Species Mouse (Mus musculus) [TaxId:10090] [88567] (346 PDB entries)
      Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region
    3. 1762372Species Norway rat (Rattus norvegicus) [TaxId:10116] [88568] (5 PDB entries)
    4. 1762385Species Synthetic construct [TaxId:32630] [158871] (1 PDB entry)
  20. 1762390Immunoglobulin light chain lambda constant domain, CL-lambda [88570] (3 species)
    1. 1762391Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88573] (1 PDB entry)
    2. 1762394Species Human (Homo sapiens) [TaxId:9606] [88572] (46 PDB entries)
    3. 1762475Species Mouse (Mus musculus) [TaxId:10090] [88571] (21 PDB entries)
      Uniprot Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
  21. 1762503Immunomodulatory protein m144, alpha-3 domain [110048] (1 species)
  22. 1762507T-cell antigen receptor [49125] (7 species)
    1. 1762508Species Human (Homo sapiens), alpha-chain [TaxId:9606] [49127] (20 PDB entries)
    2. 1762538Species Human (Homo sapiens), beta-chain [TaxId:9606] [49129] (29 PDB entries)
    3. 1762581Species Human (Homo sapiens), delta-chain [TaxId:9606] [63662] (2 PDB entries)
    4. 1762588Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63661] (2 PDB entries)
    5. 1762595Species Mouse (Mus musculus) [TaxId:10090] [226194] (2 PDB entries)
    6. 1762598Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [49126] (11 PDB entries)
    7. 1762619Species Mouse (Mus musculus), beta-chain [TaxId:10090] [49128] (15 PDB entries)
  23. 1762648Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965] (1 species)
    fat depleting factor related to class I MHC
  24. 1762660automated matches [190374] (14 species)
    not a true protein
    1. 1762661Species Chimpanzee (Pan troglodytes) [TaxId:9598] [226268] (1 PDB entry)
    2. 1762664Species Cow (Bos taurus) [TaxId:9913] [225911] (1 PDB entry)
    3. 1762669Species Escherichia coli [TaxId:562] [224854] (1 PDB entry)
    4. 1762674Species Homo sapiens [TaxId:9606] [268989] (70 PDB entries)
    5. 1762814Species Homo sapiens, [TaxId:9606] [268392] (1 PDB entry)
    6. 1762816Species Human (Homo sapiens) [TaxId:9606] [187221] (409 PDB entries)
    7. 1763624Species Llama glama [TaxId:9844] [271450] (2 PDB entries)
    8. 1763627Species Mouse (Mus musculus) [TaxId:10090] [224855] (368 PDB entries)
    9. 1764236Species Murinae, homo sapiens [TaxId:39107] [228176] (2 PDB entries)
    10. 1764241Species Mus musculus [TaxId:10090] [272441] (35 PDB entries)
    11. 1764295Species Mus musculus, [TaxId:10090] [272267] (3 PDB entries)
    12. 1764300Species Norway rat (Rattus norvegicus) [TaxId:10116] [262079] (2 PDB entries)
    13. 1764311Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [226687] (4 PDB entries)
    14. 1764317Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [226134] (5 PDB entries)

More info for Family b.1.1.2: C1 set domains (antibody constant domain-like)

Timeline for Family b.1.1.2: C1 set domains (antibody constant domain-like):