Lineage for Family b.1.1.2: C1 set domains (antibody constant domain-like)

  1. Root: SCOPe 2.01
  2. 929298Class b: All beta proteins [48724] (174 folds)
  3. 929299Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 929300Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 931881Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

Proteins:

  1. 931882beta2-microglobulin [88600] (5 species)
    1. 931883Species Cow (Bos taurus) [TaxId:9913] [48946] (3 PDB entries)
    2. 931890Species Human (Homo sapiens) [TaxId:9606] [88602] (328 PDB entries)
      Uniprot P61769 21-119 ! Uniprot P01884
    3. 932374Species Mouse (Mus musculus) [TaxId:10090] [88603] (142 PDB entries)
      Uniprot P01887
    4. 932596Species Norway rat (Rattus norvegicus) [TaxId:10116] [88601] (6 PDB entries)
    5. 932606Species Pig (Sus scrofa) [TaxId:9823] [189845] (2 PDB entries)
  2. 932610CD1, alpha-3 domain [88615] (4 species)
    1. 932611Species Human (Homo sapiens), CD1a [TaxId:9606] [101513] (3 PDB entries)
    2. 932617Species Human (Homo sapiens), CD1b [TaxId:9606] [88617] (3 PDB entries)
    3. 932621Species Human (Homo sapiens), CD1d [TaxId:9606] [158876] (2 PDB entries)
      Uniprot P15813 202-295
    4. 932626Species Mouse (Mus musculus) [TaxId:10090] [88616] (7 PDB entries)
  3. 932638Class I MHC homolog, alpha-3 domain [88610] (4 species)
    gamma, delta T-cell ligand
    1. 932639Species Human (Homo sapiens), Mic-a [TaxId:9606] [48968] (2 PDB entries)
    2. 932642Species Human (Homo sapiens), Mic-b [TaxId:9606] [74826] (1 PDB entry)
    3. 932644Species Mouse (Mus musculus), t10 [TaxId:10090] [101512] (1 PDB entry)
    4. 932649Species Mouse (Mus musculus), t22 [TaxId:10090] [88611] (2 PDB entries)
  4. 932656Class I MHC, alpha-3 domain [88604] (4 species)
    1. 932657Species Human (Homo sapiens) [TaxId:9606] [88605] (157 PDB entries)
      Uniprot P30685 25-300 ! Uniprot P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor ! Uniprot P30481 25-300 ! Uniprot P01892 25-298 ! Uniprot P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
    2. 932877Species Mouse (Mus musculus) [TaxId:10090] [88606] (89 PDB entries)
      Uniprot P01901 22-299
    3. 933026Species Rat (Rattus norvegicus), RT1-AA [TaxId:10116] [88607] (3 PDB entries)
    4. 933031Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [158875] (1 PDB entry)
  5. 933034Class II MHC alpha chain, C-terminal domain [88618] (6 species)
    1. 933035Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88619] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 933037Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88623] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 933042Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88621] (29 PDB entries)
      Uniprot P01903 28-207
      probably orthologous to the mouse I-E group
    4. 933082Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88620] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 933084Species Mouse (Mus musculus), I-A group [TaxId:10090] [88624] (26 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 933129Species Mouse (Mus musculus), I-E group [TaxId:10090] [88622] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  6. 933150Class II MHC beta chain, C-terminal domain [88625] (6 species)
    1. 933151Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88626] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 933153Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88630] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 933158Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88628] (39 PDB entries)
      Uniprot P04229 30-219
      probably orthologous to the mouse I-E group
    4. 933217Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88627] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 933219Species Mouse (Mus musculus), I-A group [TaxId:10090] [88631] (16 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 933245Species Mouse (Mus musculus), I-E group [TaxId:10090] [88629] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  7. 933266Fc (IgG) receptor, alpha-3 domain [88612] (2 species)
    1. 933267Species Human (Homo sapiens) [TaxId:9606] [88614] (1 PDB entry)
    2. 933269Species Norway rat (Rattus norvegicus) [TaxId:10116] [88613] (3 PDB entries)
  8. 933275Hemochromatosis protein Hfe, alpha-3 domain [88608] (1 species)
  9. 933282Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580] (1 species)
  10. 933287Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181] (1 species)
  11. 933293Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183] (1 species)
  12. 933299Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594] (1 species)
  13. 933304Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596] (1 species)
  14. 933311Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598] (1 species)
  15. 933318Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)
    1. 933319Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88579] (1 PDB entry)
    2. 933322Species Escherichia coli [TaxId:562] [158873] (1 PDB entry)
    3. 933326Species Human (Homo sapiens) [TaxId:9606] [88575] (172 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
    4. 933627Species Mouse (Mus musculus) [TaxId:10090] [88576] (373 PDB entries)
      Uniprot P01864 # GCAB_MOUSE Ig gamma-2A chain C region secreted form (B allele) ! Uniprot P01863 #GCAA_MOUSE Ig gamma-2A chain C region, A allele; 86% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01751 (Ig heavy chain V region B1-8/186-2) and Uniprot P01864 (Ig gamma-2A chain C region secreted form) ! Uniprot P01868 # GC1_MOUSE Ig gamma-1 chain C region secreted form ! Uniprot P01864 # GCAB_MOUSE (P01864) Ig gamma-2A chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! Uniprot P01863 # GCAA_MOUSE Ig gamma-2A chain C region, A allele ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01868 # ! GC1_MOUSE Ig gamma-1 chain C region secreted form
    5. 934121Species Mouse (Mus musculus), gamma3 [TaxId:10090] [88577] (8 PDB entries)
      Uniprot P22436 # GC3_MOUSE (P22436) Ig gamma-3 chain C region
    6. 934135Species Norway rat (Rattus norvegicus) [TaxId:10116] [88578] (5 PDB entries)
    7. 934148Species synthetic construct [TaxId:32630] [158874] (2 PDB entries)
  16. 934151Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species)
    1. 934152Species Human (Homo sapiens) [TaxId:9606] [88585] (28 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    2. 934200Species Mouse (Mus musculus) [TaxId:10090] [88586] (1 PDB entry)
    3. 934203Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88587] (1 PDB entry)
    4. 934206Species Norway rat (Rattus norvegicus) [TaxId:10116] [88588] (2 PDB entries)
  17. 934211Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589] (5 species)
    1. 934212Species Guinea pig (Cavia porcellus) [TaxId:10141] [49123] (1 PDB entry)
    2. 934214Species Human (Homo sapiens) [TaxId:9606] [88590] (28 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    3. 934265Species Mouse (Mus musculus) [TaxId:10090] [88591] (2 PDB entries)
    4. 934270Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88592] (1 PDB entry)
    5. 934273Species Norway rat (Rattus norvegicus) [TaxId:10116] [88593] (2 PDB entries)
  18. 934278Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582] (1 species)
  19. 934293Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (5 species)
    1. 934294Species Escherichia coli [TaxId:562] [158872] (3 PDB entries)
    2. 934303Species Human (Homo sapiens) [TaxId:9606] [88569] (132 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody
    3. 934519Species Mouse (Mus musculus) [TaxId:10090] [88567] (318 PDB entries)
      Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region
    4. 934944Species Norway rat (Rattus norvegicus) [TaxId:10116] [88568] (6 PDB entries)
    5. 934959Species synthetic construct [TaxId:32630] [158871] (1 PDB entry)
  20. 934961Immunoglobulin light chain lambda constant domain, CL-lambda [88570] (3 species)
    1. 934962Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88573] (1 PDB entry)
    2. 934965Species Human (Homo sapiens) [TaxId:9606] [88572] (46 PDB entries)
    3. 935047Species Mouse (Mus musculus) [TaxId:10090] [88571] (21 PDB entries)
      Uniprot Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
  21. 935075Immunomodulatory protein m144, alpha-3 domain [110048] (1 species)
  22. 935079T-cell antigen receptor [49125] (6 species)
    1. 935080Species Human (Homo sapiens), alpha-chain [TaxId:9606] [49127] (16 PDB entries)
    2. 935105Species Human (Homo sapiens), beta-chain [TaxId:9606] [49129] (28 PDB entries)
    3. 935146Species Human (Homo sapiens), delta-chain [TaxId:9606] [63662] (2 PDB entries)
    4. 935153Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63661] (2 PDB entries)
    5. 935160Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [49126] (11 PDB entries)
    6. 935181Species Mouse (Mus musculus), beta-chain [TaxId:10090] [49128] (15 PDB entries)
  23. 935210Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965] (1 species)
    fat depleting factor related to class I MHC
  24. 935222automated matches [190374] (1 species)
    not a true protein

More info for Family b.1.1.2: C1 set domains (antibody constant domain-like)

Timeline for Family b.1.1.2: C1 set domains (antibody constant domain-like):