Lineage for Family b.1.1.2: C1 set domains (antibody constant domain-like)

  1. Root: SCOP 1.69
  2. 450777Class b: All beta proteins [48724] (144 folds)
  3. 450778Fold b.1: Immunoglobulin-like beta-sandwich [48725] (23 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 450779Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 452577Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 protein domains)

Protein Domains:

  1. 452578beta2-microglobulin [88600] (4 species)
    1. 452579Species Cow (Bos taurus) [TaxId:9913] [48946] (1 PDB entry)
    2. 452581Species Human (Homo sapiens) [TaxId:9606] [88602] (85 PDB entries)
    3. 452709Species Mouse (Mus musculus) [TaxId:10090] [88603] (60 PDB entries)
    4. 452806Species Rat (Rattus norvegicus) [TaxId:10116] [88601] (6 PDB entries)
  2. 452816CD1, alpha-3 domain [88615] (3 species)
    1. 452817Species Human (Homo sapiens), CD1a [TaxId:9606] [101513] (1 PDB entry)
    2. 452820Species Human (Homo sapiens), CD1b [TaxId:9606] [88617] (3 PDB entries)
    3. 452824Species Mouse (Mus musculus) [TaxId:10090] [88616] (1 PDB entry)
  3. 452827Class I MHC homolog, alpha-3 domain [88610] (4 species)
    gamma, delta T-cell ligand
    1. 452828Species Human (Homo sapiens), Mic-a [TaxId:9606] [48968] (2 PDB entries)
    2. 452831Species Human (Homo sapiens), Mic-b [TaxId:9606] [74826] (1 PDB entry)
    3. 452833Species Mouse (Mus musculus), t10 [TaxId:10090] [101512] (1 PDB entry)
    4. 452838Species Mouse (Mus musculus), t22 [TaxId:10090] [88611] (1 PDB entry)
  4. 452843Class I MHC, alpha-3 domain [88604] (3 species)
    1. 452844Species Human (Homo sapiens) [TaxId:9606] [88605] (70 PDB entries)
    2. 452944Species Mouse (Mus musculus) [TaxId:10090] [88606] (60 PDB entries)
    3. 453040Species Rat (Rattus norvegicus), RT1-AA [TaxId:10116] [88607] (3 PDB entries)
  5. 453045Class II MHC alpha chain, C-terminal domain [88618] (6 species)
    1. 453046Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88619] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 453048Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88623] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 453053Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88621] (29 PDB entries)
      probably orthologous to the mouse I-E group
    4. 453093Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88620] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 453095Species Mouse (Mus musculus), I-A group [TaxId:10090] [88624] (10 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 453111Species Mouse (Mus musculus), I-E group [TaxId:10090] [88622] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  6. 453132Class II MHC beta chain, C-terminal domain [88625] (6 species)
    1. 453133Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88626] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 453135Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88630] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 453140Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88628] (29 PDB entries)
      probably orthologous to the mouse I-E group
    4. 453180Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88627] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 453182Species Mouse (Mus musculus), I-A group [TaxId:10090] [88631] (10 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 453198Species Mouse (Mus musculus), I-E group [TaxId:10090] [88629] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  7. 453219Fc (IgG) receptor, alpha-3 domain [88612] (2 species)
    1. 453220Species Human (Homo sapiens) [TaxId:9606] [88614] (1 PDB entry)
    2. 453222Species Rat (Rattus norvegicus) [TaxId:10116] [88613] (3 PDB entries)
  8. 453228Hemochromatosis protein Hfe, alpha-3 domain [88608] (1 species)
  9. 453235Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580] (1 species)
  10. 453240Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181] (1 species)
  11. 453244Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183] (1 species)
  12. 453248Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594] (1 species)
  13. 453253Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596] (1 species)
  14. 453260Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598] (1 species)
  15. 453267Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (5 species)
    1. 453268Species Hamster (Cricetulus griseus) [TaxId:10029] [88579] (1 PDB entry)
    2. 453271Species Human (Homo sapiens) [TaxId:9606] [88575] (82 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
    3. 453396Species Mouse (Mus musculus) [TaxId:10090] [88576] (295 PDB entries)
    4. 453777Species Mouse (Mus musculus), gamma3 [TaxId:10090] [88577] (8 PDB entries)
    5. 453791Species Rat (Rattus norvegicus) [TaxId:10116] [88578] (4 PDB entries)
  16. 453802Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species)
    1. 453803Species Human (Homo sapiens) [TaxId:9606] [88585] (22 PDB entries)
    2. 453841Species Mouse (Mus musculus) [TaxId:10090] [88586] (1 PDB entry)
    3. 453844Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88587] (1 PDB entry)
    4. 453847Species Rat (Rattus norvegicus) [TaxId:10116] [88588] (2 PDB entries)
  17. 453852Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589] (5 species)
    1. 453853Species Guinea pig (Cavia porcellus) [TaxId:10141] [49123] (1 PDB entry)
    2. 453855Species Human (Homo sapiens) [TaxId:9606] [88590] (22 PDB entries)
    3. 453893Species Mouse (Mus musculus) [TaxId:10090] [88591] (2 PDB entries)
    4. 453898Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88592] (1 PDB entry)
    5. 453901Species Rat (Rattus norvegicus) [TaxId:10116] [88593] (2 PDB entries)
  18. 453906Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582] (1 species)
  19. 453918Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (3 species)
    1. 453919Species Human (Homo sapiens) [TaxId:9606] [88569] (78 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
    2. 454044Species Mouse (Mus musculus) [TaxId:10090] [88567] (277 PDB entries)
    3. 454400Species Rat (Rattus norvegicus) [TaxId:10116] [88568] (4 PDB entries)
  20. 454411Immunoglobulin light chain lambda constant domain, CL-lambda [88570] (3 species)
    1. 454412Species Hamster (Cricetulus griseus) [TaxId:10029] [88573] (1 PDB entry)
    2. 454415Species Human (Homo sapiens) [TaxId:9606] [88572] (42 PDB entries)
    3. 454490Species Mouse (Mus musculus) [TaxId:10090] [88571] (20 PDB entries)
  21. 454516Immunomodulatory protein m144, alpha-3 domain [110048] (1 species)
  22. 454519T-cell antigen receptor [49125] (6 species)
    1. 454520Species Human (Homo sapiens), alpha-chain [TaxId:9606] [49127] (9 PDB entries)
    2. 454530Species Human (Homo sapiens), beta-chain [TaxId:9606] [49129] (11 PDB entries)
    3. 454543Species Human (Homo sapiens), delta-chain [TaxId:9606] [63662] (1 PDB entry)
    4. 454548Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63661] (1 PDB entry)
    5. 454553Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [49126] (6 PDB entries)
    6. 454565Species Mouse (Mus musculus), beta-chain [TaxId:10090] [49128] (11 PDB entries)
  23. 454586Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965] (1 species)
    fat depleting factor related to class I MHC

More info for Family b.1.1.2: C1 set domains (antibody constant domain-like)

Timeline for Family b.1.1.2: C1 set domains (antibody constant domain-like):