Lineage for Family b.1.1.1: V set domains (antibody variable domain-like)

  1. Root: SCOP 1.69
  2. 450777Class b: All beta proteins [48724] (144 folds)
  3. 450778Fold b.1: Immunoglobulin-like beta-sandwich [48725] (23 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 450779Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 450780Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (27 proteins)

Proteins:

  1. 450781Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), N-terminal domain [81942] (1 species)
  2. 450784Camelid IG heavy chain variable domain, VHh [88563] (2 species)
    1. 450785Species Camel (Camelus dromedarius) [TaxId:9838] [88564] (13 PDB entries)
    2. 450813Species Llama (Lama glama) [TaxId:9844] [88565] (7 PDB entries)
  3. 450822CD2, first domain [48740] (2 species)
    1. 450823Species Human (Homo sapiens) [TaxId:9606] [48741] (4 PDB entries)
    2. 450829Species Rat (Rattus norvegicus) [TaxId:10116] [48742] (5 PDB entries)
  4. 450842CD2-binding domain of CD58, N-terminal domain [48743] (1 species)
  5. 450848CD4 V-set domains [48737] (2 species)
    1. 450849Species Human (Homo sapiens) [TaxId:9606] [48738] (15 PDB entries)
    2. 450874Species Rat (Rattus rattus) [TaxId:10117] [48739] (1 PDB entry)
  6. 450876CD8 [48734] (2 species)
    1. 450877Species Human (Homo sapiens) [TaxId:9606] [48735] (2 PDB entries)
    2. 450881Species Mouse (Mus musculus) [TaxId:10090] [48736] (2 PDB entries)
  7. 450888CD80, N-terminal domain [48745] (1 species)
    a soluble form of b7-1
  8. 450893CD86 (b7-2), N-terminal domain [63635] (1 species)
  9. 450899Coxsackie virus and adenovirus receptor (Car), domain 1 [48730] (1 species)
  10. 450909HSV glycoprotein D [63637] (1 species)
  11. 450916Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
    1. 450917Species Engineered (including hybrid species) [88562] (31 PDB entries)
    2. 450968Species Hamster (Cricetulus griseus) [TaxId:10029] [88561] (1 PDB entry)
    3. 450971Species Human (Homo sapiens), cluster 1 [TaxId:9606] [88544] (16 PDB entries)
    4. 451000Species Human (Homo sapiens), cluster 2.1 [TaxId:9606] [88545] (3 PDB entries)
    5. 451006Species Human (Homo sapiens), cluster 2.2 [TaxId:9606] [88546] (1 PDB entry)
    6. 451008Species Human (Homo sapiens), cluster 3 [TaxId:9606] [88547] (11 PDB entries)
    7. 451024Species Human (Homo sapiens), cluster 4 [TaxId:9606] [101505] (1 PDB entry)
    8. 451027Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (42 PDB entries)
    9. 451081Species Mouse (Mus musculus), cluster 2.1 [TaxId:10090] [88549] (16 PDB entries)
    10. 451105Species Mouse (Mus musculus), cluster 2.2 [TaxId:10090] [88550] (49 PDB entries)
    11. 451179Species Mouse (Mus musculus), cluster 3.1 [TaxId:10090] [88551] (28 PDB entries)
    12. 451214Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (143 PDB entries)
    13. 451401Species Mouse (Mus musculus), cluster 3.3 [TaxId:10090] [88553] (1 PDB entry)
    14. 451404Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88554] (32 PDB entries)
    15. 451450Species Mouse (Mus musculus), cluster 5 [TaxId:10090] [88555] (35 PDB entries)
    16. 451496Species Mouse (Mus musculus), cluster 6 [TaxId:10090] [88556] (12 PDB entries)
    17. 451511Species Mouse (Mus musculus), cluster 7.1 [TaxId:10090] [88557] (34 PDB entries)
    18. 451552Species Mouse (Mus musculus), cluster 7.2 [TaxId:10090] [88558] (20 PDB entries)
    19. 451575Species Mouse (Mus musculus), cluster 7.3 [TaxId:10090] [88559] (2 PDB entries)
    20. 451578Species Rat (Rattus norvegicus) [TaxId:10116] [88560] (14 PDB entries)
  12. 451612Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
    VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species
    1. 451613Species Engineered (including hybrid species) [88533] (31 PDB entries)
    2. 451663Species Human (Homo sapiens), cluster 1 [TaxId:9606] [88520] (19 PDB entries)
    3. 451707Species Human (Homo sapiens), cluster 2 [TaxId:9606] [88521] (10 PDB entries)
    4. 451723Species Human (Homo sapiens), cluster 3.1 [TaxId:9606] [88522] (5 PDB entries)
    5. 451733Species Human (Homo sapiens), cluster 3.2 [TaxId:9606] [88523] (7 PDB entries)
    6. 451743Species Mouse (Mus musculus), cluster 1.1 [TaxId:10090] [88524] (126 PDB entries)
    7. 451904Species Mouse (Mus musculus), cluster 1.2 [TaxId:10090] [88525] (34 PDB entries)
    8. 451954Species Mouse (Mus musculus), cluster 2 [TaxId:10090] [88526] (24 PDB entries)
    9. 451987Species Mouse (Mus musculus), cluster 3.1 [TaxId:10090] [88527] (12 PDB entries)
    10. 452004Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88528] (19 PDB entries)
    11. 452031Species Mouse (Mus musculus), cluster 3.3 [TaxId:10090] [88529] (2 PDB entries)
    12. 452035Species Mouse (Mus musculus), cluster 3.4 [TaxId:10090] [88530] (3 PDB entries)
    13. 452039Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (162 PDB entries)
    14. 452248Species Rat (Rattus norvegicus) [TaxId:10116] [88532] (7 PDB entries)
  13. 452262Immunoglobulin light chain lambda variable domain, VL-lambda [88534] (9 species)
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family
    1. 452263Species Hamster (Cricetulus griseus) [TaxId:10029] [88542] (1 PDB entry)
    2. 452266Species Human (Homo sapiens), cluster 1 [TaxId:9606] [88535] (4 PDB entries)
    3. 452275Species Human (Homo sapiens), cluster 2 [TaxId:9606] [88536] (9 PDB entries)
    4. 452289Species Human (Homo sapiens), cluster 3.1 [TaxId:9606] [88537] (1 PDB entry)
    5. 452291Species Human (Homo sapiens), cluster 3.2 [TaxId:9606] [88538] (1 PDB entry)
    6. 452293Species Human (Homo sapiens), cluster 4 [TaxId:9606] [88539] (23 PDB entries)
    7. 452339Species Human (Homo sapiens), cluster 5 [TaxId:9606] [88540] (3 PDB entries)
    8. 452345Species Mouse (Mus musculus) [TaxId:10090] [88541] (33 PDB entries)
    9. 452390Species Rat (Rattus norvegicus) [TaxId:10116] [101504] (7 PDB entries)
  14. 452411Immunoreceptor CTLA-4 (CD152), N-terminal fragment [48939] (2 species)
    1. 452412Species Human (Homo sapiens) [TaxId:9606] [48940] (3 PDB entries)
    2. 452418Species Mouse (Mus musculus) [TaxId:10090] [48941] (1 PDB entry)
  15. 452423Junction adhesion molecule, JAM, N-terminal domain [48747] (2 species)
    1. 452424Species Human (Homo sapiens) [TaxId:9606] [89180] (1 PDB entry)
    2. 452427Species Mouse (Mus musculus) [TaxId:10090] [48748] (1 PDB entry)
  16. 452429Myelin membrane adhesion molecule P0 [48728] (1 species)
  17. 452432Myelin oligodendrocyte glycoprotein (MOG) [89174] (1 species)
  18. 452438N-terminal domain of sialic acid binding Ig-like lectin 7 (SIGLEC-7, p75/AIRM1) [89176] (1 species)
  19. 452443N-terminal domain of sialoadhesin [48732] (1 species)
  20. 452452NK cell activating receptor NKP44 [89178] (1 species)
    a triggering partner in natural cytotoxicity
  21. 452455Novel antigen receptor (against lysozyme) [110042] (1 species)
  22. 452460Novel antigen receptor 12Y-1 [110044] (1 species)
  23. 452463Novel antigen receptor 12Y-2 [110046] (1 species)
  24. 452467Programmed cell death protein 1, PD1, extracellular domain [101510] (1 species)
  25. 452470T-cell antigen receptor [48933] (6 species)
    sequences may differ within each classified species
    1. 452471Species Human (Homo sapiens), alpha-chain [TaxId:9606] [48935] (10 PDB entries)
    2. 452482Species Human (Homo sapiens), beta-chain [TaxId:9606] [48937] (11 PDB entries)
    3. 452495Species Human (Homo sapiens), delta-chain [TaxId:9606] [48938] (2 PDB entries)
    4. 452502Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63651] (1 PDB entry)
    5. 452507Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [48934] (16 PDB entries)
    6. 452536Species Mouse (Mus musculus), beta-chain [TaxId:10090] [48936] (17 PDB entries)
  26. 452565TREM-1 (triggering receptor expressed on myeloid cells 1) [101506] (1 species)
  27. 452573Tyrosine-protein kinase receptor tyro3, N-terminal domain [101508] (1 species)

More info for Family b.1.1.1: V set domains (antibody variable domain-like)

Timeline for Family b.1.1.1: V set domains (antibody variable domain-like):