Lineage for Class b: All beta proteins

  1. Root: SCOP 1.63
  2. 218896Class b: All beta proteins [48724] (119 folds)

Folds:

  1. 218897b.1: Immunoglobulin-like beta-sandwich [48725] (20 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  2. 223643b.2: Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (8 superfamilies)
    sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
  3. 223936b.3: Prealbumin-like [49451] (6 superfamilies)
    sandwich; 7 strands in 2 sheets, greek-key
    variations: some members have additional 1-2 strands to common fold
  4. 224371b.4: HSP40/DnaJ peptide-binding domain [49492] (1 superfamily)
    sandwich; 6 strands in 2 sheets
  5. 224378b.5: alpha-Amylase inhibitor tendamistat [49497] (1 superfamily)
    sandwich; 6 strands in 2 sheets
  6. 224388b.6: Cupredoxin-like [49502] (2 superfamilies)
    sandwich; 7 strands in 2 sheets, greek-key
    variations: some members have additional 1-2 strands
  7. 224988b.7: C2 domain-like [49561] (4 superfamilies)
    sandwich; 8 strands in 2 sheets; greek-key
  8. 225118b.8: TRAF domain-like [49598] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key
  9. 225183b.9: Neurophysin II [49605] (1 superfamily)
    sandwich; 8 strands in 2 sheets; meander
  10. 225197b.10: Viral coat and capsid proteins [49610] (1 superfamily)
    sandwich; 8 strands in 2 sheets; jelly-roll
    variations: some members have additional 1-2 strands
  11. 225638b.11: gamma-Crystallin-like [49694] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key
    duplication: has internal pseudo twofold symmetry
  12. 225723b.12: Lipase/lipooxygenase domain (PLAT/LH2 domain) [49722] (1 superfamily)
    sandwich; 8 strands in 2 sheets; complex topology
    duplication: has weak internal pseudo twofold symmetry
  13. 225773b.13: Nucleoplasmin/PNGase F-like [49741] (3 superfamilies)
    sandwich; 8 strands in 2 sheets; jelly-roll
  14. 225847b.14: Calpain large subunit, middle domain (domain III) [49757] (1 superfamily)
    sandwich; 8 strands in 2 sheets; jelly-roll
  15. 225856b.15: HSP20-like chaperones [49763] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key
  16. 225879b.16: Ecotin, trypsin inhibitor [49771] (1 superfamily)
    sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
  17. 225902b.17: PEBP-like [49776] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
  18. 225929b.18: Galactose-binding domain-like [49784] (1 superfamily)
    sandwich; 9 strands in 2 sheets; jelly-roll
  19. 226172b.19: Viral protein domain [49817] (1 superfamily)
    sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
  20. 226261b.20: F-MuLV receptor-binding domain [49829] (1 superfamily)
    sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
  21. 226267b.21: Virus attachment protein [49834] (1 superfamily)
    sandwich, 10 strands in 2 sheets; greek-key
  22. 226299b.22: TNF-like [49841] (1 superfamily)
    sandwich, 10 strands in 2 sheets; jelly-roll
  23. 226388b.23: Spermadhesin, CUB domain [49853] (1 superfamily)
    sandwich, 10 strands in 2 sheets; jelly-roll
  24. 226400b.24: Hyaluronate lyase-like, C-terminal domain [49862] (1 superfamily)
    sandwich, 10 strands in 2 sheets; "folded meander"
  25. 226426b.25: Osmotin, thaumatin-like protein [49869] (1 superfamily)
    sandwich; 11 strands in 2 sheets
  26. 226447b.26: SMAD/FHA domain [49878] (1 superfamily)
    sandwich; 11 strands in 2 sheets; greek-key
  27. 226507b.27: Soluble secreted chemokine inhibitor, VCCI [49888] (1 superfamily)
    sandwich; 11 strands in 2 sheets; greek-key
  28. 226514b.28: Paculovirus p35 [49893] (1 superfamily)
    sandwich; 14 strands in 2 sheets; greek-key
  29. 226527b.29: Concanavalin A-like lectins/glucanases [49898] (1 superfamily)
    sandwich; 12-14 strands in 2 sheets; complex topology
  30. 227198b.30: Supersandwich [49993] (3 superfamilies)
    sandwich; 18 strands in 2 sheets
  31. 227464b.31: EV matrix protein [50011] (1 superfamily)
    consists of two beta-sandwich domains of similar topologies
  32. 227470b.32: gp9 [50016] (1 superfamily)
    consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
  33. 227477b.33: ISP domain [50021] (1 superfamily)
    consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
  34. 227526b.34: SH3-like barrel [50036] (12 superfamilies)
    barrel, partly opened; n*=4, S*=8; meander
    the last strand is interrupted by a turn of 3-10 helix
  35. 227997b.35: GroES-like [50128] (2 superfamilies)
    contains barrel, partly opened; n*=4, S*=8; meander
  36. 228215b.36: PDZ domain-like [50155] (1 superfamily)
    contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
  37. 228312b.37: N-terminal domains of the minor coat protein g3p [50175] (1 superfamily)
    core: barrel, in some members open; n*=4, S*=8; meander
  38. 228326b.38: Sm-like fold [50181] (2 superfamilies)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology
  39. 228536b.39: Ribosomal protein L14 [50192] (1 superfamily)
    barrel, closed; n=5, S=8, meander
  40. 228551b.40: OB-fold [50198] (9 superfamilies)
    barrel, closed or partly opened n=5, S=10 or S=8; greek-key
  41. 229641b.41: Photosynthetic reaction centre, H-chain, cytoplasmic domain [50345] (1 superfamily)
    core: barrel, partly opened; n*=5, S*=8; meander
  42. 229692b.42: beta-Trefoil [50352] (6 superfamilies)
    barrel, closed; n=6, S=12; and a hairpin triplet; meander
    duplication: has internal pseudo threefold symmetry
  43. 229967b.43: Reductase/isomerase/elongation factor common domain [50412] (4 superfamilies)
    barrel, closed; n=6, S=10; greek-key
  44. 230193b.44: EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain [50464] (1 superfamily)
    barrel, closed; n=6, S=10; greek-key
  45. 230244b.45: FMN-binding split barrel [50474] (1 superfamily)
    barrel; n=6, S=10; greek-key
  46. 230275b.46: FMT C-terminal domain-like [50485] (1 superfamily)
    barrel, open; n*=6, S*=10; greek-key
  47. 230291b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  48. 231255b.48: mu transposase, C-terminal domain [50609] (1 superfamily)
    barrel; n=6, S=8, greek-key
  49. 231263b.49: Domain of alpha and beta subunits of F1 ATP synthase-like [50614] (2 superfamilies)
    barrel, closed; n=6, S=8; greek-key
  50. 231370b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  51. 231935b.51: ValRS/IleRS/LeuRS editing domain [50676] (1 superfamily)
    core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
  52. 231956b.52: Double psi beta-barrel [50684] (2 superfamilies)
    barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
  53. 232045b.53: Ribosomal protein L25-like [50714] (1 superfamily)
    barrel, closed; n=6, S=10; complex topology
  54. 232071b.54: Core binding factor beta, CBF [50722] (1 superfamily)
    barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
  55. 232087b.55: PH domain-like [50728] (1 superfamily)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  56. 232263b.56: Transcription factor IIA (TFIIA), N-terminal domain [50783] (1 superfamily)
    barrel, closed; n=6, S=12; mixed beta-sheet
  57. 232270b.57: Herpes virus serine proteinase, assemblin [50788] (1 superfamily)
    core: barrel, closed; n=7, S=8; complex topology
  58. 232326b.58: PK beta-barrel domain-like [50799] (1 superfamily)
    barrel, closed; n=7, S=10; complex topology
  59. 232440b.59: XRCC4, N-terminal domain [50808] (1 superfamily)
    barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
  60. 232449b.60: Lipocalins [50813] (1 superfamily)
    barrel, closed or opened; n=8, S=12; meander
  61. 232728b.61: Streptavidin-like [50875] (5 superfamilies)
    barrel, closed; n=8, S=10; meander
  62. 232982b.62: Cyclophilin (peptidylprolyl isomerase) [50890] (1 superfamily)
    barrel, closed; n=8, S=10; complex topology
  63. 233098b.63: Oncogene products [50903] (1 superfamily)
    barrel, closed; n=8, S=10; one overside connection
  64. 233112b.64: Mannose 6-phosphate receptor domain [50910] (1 superfamily)
    barrel, partly open; n*=8, S*=10; one psi loop
  65. 233131b.65: triple barrel [50915] (1 superfamily)
    dimer of two non-identical subunits; forms two similar barrels, n=8, S=10 each, that are fused together with the formation of third barrel, n=6, S=8
  66. 233146b.66: 4-bladed beta-propeller [50922] (1 superfamily)
    consists of four 4-stranded beta-sheet motifs; meander
  67. 233175b.67: 5-bladed beta-propeller [50933] (2 superfamilies)
    consists of five 4-stranded beta-sheet motifs; meander
  68. 233193b.68: 6-bladed beta-propeller [50938] (7 superfamilies)
    consists of six 4-stranded beta-sheet motifs; meander
  69. 233372b.69: 7-bladed beta-propeller [50964] (10 superfamilies)
    consists of seven 4-stranded beta-sheet motifs; meander
  70. 233551b.70: 8-bladed beta-propeller [50997] (3 superfamilies)
    consists of eight 4-stranded beta-sheet motifs; meander
    also found in some members of the WD40-repeat superfamily
  71. 233630b.71: alpha-Amylases, C-terminal beta-sheet domain [51010] (1 superfamily)
    folded sheet; greek-key
  72. 233857b.72: WW domain-like [51044] (2 superfamilies)
    core: 3-stranded meander beta-sheet
  73. 233918b.73: Head domain of nucleotide exchange factor GrpE [51063] (1 superfamily)
    small mixed beta-sheet, 4 "generalized" strands
  74. 233925b.74: Carbonic anhydrase [51068] (1 superfamily)
    single sheet; 10 strands
  75. 234125b.75: Bacteriochlorophyll A protein [51080] (1 superfamily)
    single sheet; 16 strands; meander
  76. 234136b.76: open-sided beta-meander [51086] (2 superfamilies)
    single sheet formed by beta-hairpin repeats; exposed on both sides in the middle
  77. 234156b.77: beta-Prism I [51091] (3 superfamilies)
    consists of 3 4-stranded sheets; strands are parallel to the 3-fold axis
    duplication: has internal pseudo threefold symmetry
  78. 234220b.78: beta-Prism II [51109] (1 superfamily)
    consists of 3 4-stranded sheets; strands are perpendicular to the 3-fold axis
    duplication: consists of two domains of this fold
  79. 234260b.79: beta-Roll [51119] (1 superfamily)
    contains a parallel beta-helix that binds calcium ions between its turns
  80. 234282b.80: Single-stranded right-handed beta-helix [51125] (5 superfamilies)
    superhelix with each turn made by 3 strands with short links
    duplication: turns of the helix are structural repeats
  81. 234409b.81: Single-stranded left-handed beta-helix [51160] (2 superfamilies)
    superhelix with each turn made by 3 strands with short links
  82. 234509b.82: Double-stranded beta-helix [51181] (7 superfamilies)
    one turn of helix is made by two pairs of antiparallel strands linked with short turns
    has appearance of a sandwich of distinct architecture and jelly-roll topology
  83. 234863b.83: Triple beta-spiral [51224] (1 superfamily)
    trimer formed by the interlocking beta-hairpin repeat units
  84. 234880b.84: Barrel-sandwich hybrid [51229] (3 superfamilies)
    sandwich of half-barrel shaped beta-sheets
  85. 235002b.85: beta-clip [51268] (7 superfamilies)
    double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
  86. 235167b.86: Hedgehog/intein (Hint) domain [51293] (1 superfamily)
    complex fold made of five beta-hairpin units and a b-ribbon arc
  87. 235192b.87: LexA/Signal peptidase [51305] (1 superfamily)
    complex fold made of several coiled beta-sheets; contains an SH3-like barrel
  88. 235235b.88: Mss4-like [51315] (1 superfamily)
    complex fold made of several coiled beta-sheets
  89. 235254b.89: Cyanovirin-N [51321] (1 superfamily)
    complex fold
  90. 235275b.90: Head-binding domain of phage P22 tailspike protein [51326] (1 superfamily)
    complex fold made of bifurcated and partly folded beta-sheet
  91. 235286b.91: E2 regulatory, transactivation domain [51331] (1 superfamily)
    complex fold made of bifurcated and coiled beta-sheets
  92. 235294b.92: Composite domain of metallo-dependent hydrolases [51337] (1 superfamily)
    pseudobarrel; mixed sheet of 7 strand folded upon itself and "buckled" by two beta-turns
  93. 235380b.93: Epsilon subunit of F1F0-ATP synthase N-terminal domain [51343] (1 superfamily)
    pseudobarrel: sandwich of two sheets packed at a positive interstrand angle and interconnected with many short turns
  94. 235392b.94: Olfactory marker protein [63696] (1 superfamily)
    sandwich; 8 strands in 2 sheets; jelly-roll
  95. 235404b.95: Ganglioside M2 (gm2) activator [63706] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
  96. 235412b.96: Nicotinic receptor ligand binding domain-like [63711] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
  97. 235422b.97: Equinatoxin II (eqtII, tenebrosin C) [63723] (1 superfamily)
    sandwich, 10 strands in 2 sheets;
  98. 235430b.98: Leukotriene A4 hydrolase N-terminal domain [63736] (1 superfamily)
    duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
  99. 235437b.100: Sortase [63816] (1 superfamily)
    barrel, closed; n=8, S=10; mixed sheet; two overside connections
  100. 235443b.101: Ribonuclease domain of colicin E3 [63839] (1 superfamily)
    twisted meander beta-sheet of 6 strands
  101. 235451b.102: Methuselah ectodomain [63876] (1 superfamily)
    complex fold
  102. 235458b.103: Molybdenum cofactor biosynthesis protein MoeA, N-terminal and linker domains [63881] (1 superfamily)
    complex fold made of bifurcated and coiled b-sheets
  103. 235469b.104: P-domain of calnexin/calreticulin [63886] (1 superfamily)
    non-globular proline-rich hairpin
  104. 235480b.105: Penicillin-binding protein 5, C-terminal domain [69188] (1 superfamily)
    sandwich; 6 strands in 2 sheets
  105. 235487b.106: Phage tail proteins [69278] (1 superfamily)
    core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
  106. 235498b.107: Urease metallochaperone UreE, N-terminal domain [69286] (1 superfamily)
    barrel, closed; n=6, S=8; a crossover loop topology
  107. 235516b.108: Triple-stranded beta-helix [69348] (1 superfamily)
    (homo)trimer; each chain donates 3 beta-strands per turn of the helix
  108. 235526b.109: beta-hairpin stack [69359] (1 superfamily)
    Trp-rich beta-hairpin repeat units form helical structures of 3 units per turn
  109. 235541b.110: Colicin E3 translocation domain [69368] (1 superfamily)
    complex fold made of several coiled beta-sheets
  110. 235548b.111: Small protein B (SmpB) [74981] (1 superfamily)
    barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
  111. 235556b.112: C-terminal domain of octopus hemocyanin [81278] (1 superfamily)
    six-stranded beta-sandwich, jelly-roll/greek-key topology
  112. 235563b.113: N-terminal domain of MutM-like DNA repair proteins [81625] (1 superfamily)
    pseudobarrel; capped on both ends by alpha-helices
  113. 235589b.114: N-utilization substance G protein NusG, insert domain [82003] (1 superfamily)
    sandwich; 8 strands in 2 sheets; meander
  114. 235599b.115: Fucose-binding lectin II (PA-IIL) [82025] (1 superfamily)
    sandwich; 9 strands in 2 sheets; greek-key
  115. 235608b.116: Viral chemokine binding protein m3 [82045] (1 superfamily)
  116. 235616b.117: Obg-fold [82050] (1 superfamily)
    this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
    these regions form six left-handed collagen-like helices packed and H-bonded together
  117. 235623b.118: FAS1 domain [82152] (1 superfamily)
    core: barrel, closed; n=7, S=12; meander
  118. 235630b.119: C-terminal autoproteolytic domain of nucleoporin nup98 [82214] (1 superfamily)
    multisheet protein with a mixture of beta-sandwich and beta-prism features
  119. 235637b.120: Tp47 lipoprotein, N-terminal domain [82219] (1 superfamily)
    complex fold; consists of two intertwined subdomains

More info for Class b: All beta proteins

Timeline for Class b: All beta proteins: