| Class a: All alpha proteins [46456] (258 folds) |
| Fold a.133: Phospholipase A2, PLA2 [48618] (1 superfamily) common core: 2 helices, disulfide-linked, and a calcium-binding loop |
Superfamily a.133.1: Phospholipase A2, PLA2 [48619] (3 families) ![]() |
| Family a.133.1.2: Vertebrate phospholipase A2 [48623] (2 proteins) |
| Protein Snake phospholipase A2 [48624] (35 species) |
| Bothrops pirajai, Piratoxin-II (PRTX-II) [TaxId:113192] [48633] (1 PDB entry) |
| Domain d1qlla_: 1qll A: [19556] |
| Domain d1qllb_: 1qll B: [19557] complexed with tda |
| Broad-banded copperhead (Agkistrodon contortrix laticinctus) [TaxId:37195] [101483] (3 PDB entries) |
| Domain d1s8ga_: 1s8g A: [98733] complexed with gol, lau, so4 |
| Domain d1s8ha_: 1s8h A: [98734] complexed with so4 |
| Domain d1s8ia_: 1s8i A: [98735] complexed with so4 |
| Cerrophidion godmani, formerly Bothrops godmani [TaxId:44722] [48645] (1 PDB entry) Monomeric Lys-49 phospholipase A2 homologue |
| Domain d1goda_: 1god A: [19617] |
| Eastern cottonmouth snake (Agkistrodon piscivorus piscivorus) [TaxId:8716] [48629] (2 PDB entries) |
| Domain d1ppaa_: 1ppa A: [19550] complexed with anl |
| Domain d1vapa_: 1vap A: [19548] |
| Domain d1vapb_: 1vap B: [19549] |
| Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [74796] (2 PDB entries) monomeric Lys-49 phospholipase A2 homologue |
| Domain d1mc2a_: 1mc2 A: [74622] complexed with ipa |
| Domain d1mg6a_: 1mg6 A: [79091] |
| Indian cobra (Naja naja sagittifera), acidic isoform 1 [TaxId:195058] [89168] (1 PDB entry) |
| Domain d1sz8a_: 1sz8 A: [99044] complexed with acy, ca, po4 |
| Indian cobra (Naja naja sagittifera), calcium-free isoform 5 [TaxId:195058] [89172] (2 PDB entries) |
| Domain d1mh7a_: 1mh7 A: [84962] |
| Domain d1mh8a_: 1mh8 A: [84963] possibly another isoform with isoleucine at second position |
| Indian cobra (Naja naja sagittifera), isoform 2 [TaxId:195058] [89169] (2 PDB entries) heterodimer of two different isoforms |
| Domain d1mh2a_: 1mh2 A: [84960] zinc containing heterodimer of two different isoforms complexed with acy, zn |
| Domain d1s6ba_: 1s6b A: [98592] heterodimer of two different isoforms complexed with acy, ca, po4 |
| Indian cobra (Naja naja sagittifera), isoform 3 [TaxId:195058] [89170] (2 PDB entries) heterodimer of two different isoforms |
| Domain d1mh2b_: 1mh2 B: [84961] zinc containing heterodimer of two different isoforms complexed with acy, zn |
| Domain d1s6bb_: 1s6b B: [98593] heterodimer of two different isoforms complexed with acy, ca, po4 |
| Indian cobra (Naja naja sagittifera), isoform 4 [TaxId:195058] [89171] (7 PDB entries) |
| Domain d1ln8a_: 1ln8 A: [84634] complexed with ca, po4 |
| Domain d1mf4a_: 1mf4 A: [91261] complexed with a designed peptide inhibitor complexed with ca |
| Domain d1oxra_: 1oxr A: [93714] complexed with aspirin complexed with ain, ca |
| Domain d1t37a_: 1t37 A: [99116] complexed with act |
| Domain d1td7a_: 1td7 A: [106771] complexed with ca, nfl |
| Domain d1yxla1: 1yxl A:1-120 [124191] automatically matched to d1oxra_ complexed with acy, ca, po4 |
| Domain d1zm6a1: 1zm6 A:1-120 [125335] automatically matched to d1t37a_ complexed with act |
| Indian cobra (Naja naja) [TaxId:35670] [48626] (4 PDB entries) |
| Domain d1a3da_: 1a3d A: [19517] complexed with na |
| Domain d1a3fa_: 1a3f A: [19521] |
| Domain d1a3fb_: 1a3f B: [19522] |
| Domain d1a3fc_: 1a3f C: [19523] |
| Domain d1psha_: 1psh A: [19518] |
| Domain d1pshb_: 1psh B: [19519] |
| Domain d1pshc_: 1psh C: [19520] complexed with ca |
| Domain d1xxwa1: 1xxw A:1-120 [122431] automatically matched to d1a3d__ complexed with acy, zn |
| Domain d1xxwb1: 1xxw B:1-119 [122432] automatically matched to d1a3d__ complexed with acy, zn |
| Indian cobra (Naja naja), a C49 isoform 2 [TaxId:35670] [89166] (1 PDB entry) |
| Domain d1owsa_: 1ows A: [87491] zinc containing heterodimer of two different isoforms complexed with nag, zn |
| Indian cobra (Naja naja), isoform 3 [TaxId:35670] [89167] (1 PDB entry) |
| Domain d1owsb_: 1ows B: [87492] zinc containing heterodimer of two different isoforms complexed with nag, zn |
| Indian krait (Bungarus caeruleus), different isoforms [TaxId:132961] [48636] (8 PDB entries) |
| Domain d1dpya_: 1dpy A: [19562] complexed with na |
| Domain d1fe5a_: 1fe5 A: [19563] complexed with ca |
| Domain d1g0za_: 1g0z A: [83263] |
| Domain d1g0zb_: 1g0z B: [83264] complexed with cl; mutant |
| Domain d1g2xa_: 1g2x A: [83265] |
| Domain d1g2xb_: 1g2x B: [83266] |
| Domain d1g2xc_: 1g2x C: [83267] trimeric isoform |
| Domain d1po8a_: 1po8 A: [94966] complexed with na, shv |
| Domain d1tc8a_: 1tc8 A: [106758] complexed with na, tda |
| Domain d1u4ja_: 1u4j A: [107673] |
| Domain d1u4jb_: 1u4j B: [107674] complexed with acy, cl, man, na |
| Domain d2osna1: 2osn A:3-120 [139300] automatically matched to d1g2xa_ complexed with cl |
| Jararacussu (Bothrops jararacussu) [TaxId:8726] [101487] (4 PDB entries) |
| Domain d1u73a_: 1u73 A: [113075] |
| Domain d1u73b_: 1u73 B: [113076] |
| Domain d1umvx_: 1umv X: [99630] acidic, non-myotoxic phospholipase A2 complexed with ca |
| Domain d1zl7a1: 1zl7 A:1-122 [125237] automatically matched to d1umvx_ complexed with ca, gol |
| Domain d1zlba1: 1zlb A:1-122 [125248] automatically matched to d1umvx_ |
| King cobra (Ophiophagus hannah) [TaxId:8665] [81939] (1 PDB entry) |
| Domain d1gp7a_: 1gp7 A: [76251] |
| Domain d1gp7b_: 1gp7 B: [76252] |
| Domain d1gp7c_: 1gp7 C: [76253] complexed with ca |
| King cobra (Ophiophagus hannah), an acidic isoform [TaxId:8665] [101482] (1 PDB entry) |
| Domain d1m8ta_: 1m8t A: [91227] |
| Domain d1m8tb_: 1m8t B: [91228] |
| Domain d1m8tc_: 1m8t C: [91229] |
| Domain d1m8td_: 1m8t D: [91230] |
| Domain d1m8te_: 1m8t E: [91231] |
| Domain d1m8tf_: 1m8t F: [91232] complexed with ca, hez |
| Mainland tiger snake (Notechis scutatus scutatus), notechis II-5 [TaxId:8663] [48632] (1 PDB entry) neurotoxic phospholipase a2 |
| Domain d2nota_: 2not A: [19554] |
| Domain d2notb_: 2not B: [19555] |
| Mainland tiger snake (Notechis scutatus scutatus), notexin [TaxId:8663] [48631] (1 PDB entry) presynaptic neurotoxic phospholipase A2 |
| Domain d1ae7a_: 1ae7 A: [19553] complexed with so4 |
| Many-banded krait (Bungarus multicinctus), beta2-bungarotoxin [TaxId:8616] [48642] (1 PDB entry) |
| Domain d1buna_: 1bun A: [19614] Other proteins in same PDB: d1bunb_ complexed with na |
| Neuwied's lancehead (Bothrops neuwiedi pauloensis), different isoforms [TaxId:95649] [110032] (2 PDB entries) |
| Domain d1pa0a_: 1pa0 A: [104097] |
| Domain d1pa0b_: 1pa0 B: [104098] |
| Domain d1pc9a_: 1pc9 A: [104107] |
| Domain d1pc9b_: 1pc9 B: [104108] |
| Russell's viper (Vipera russelli) [TaxId:8707] [48634] (1 PDB entry) anticoagulant class II phospholipase A2 |
| Domain d1vipa_: 1vip A: [19558] complexed with so4 |
| Sand viper (Vipera ammodytes meridionalis), vipoxin catalytic subunit [TaxId:8704] [88518] (2 PDB entries) |
| Domain d1aokb_: 1aok B: [19561] complex with inhibitory subunit complexed with act |
| Domain d1jltb_: 1jlt B: [66868] complex with inhibitory subunit complexed with mpd |
| Sand viper (Vipera ammodytes meridionalis), vipoxin inhibitor [TaxId:8704] [88517] (5 PDB entries) |
| Domain d1aoka_: 1aok A: [19560] complex with catalytic subunit complexed with act |
| Domain d1jlta_: 1jlt A: [66867] complex with catalytic subunit complexed with mpd |
| Domain d1q5ta_: 1q5t A: [95932] |
| Domain d1q5tb_: 1q5t B: [95933] complexed with so4 |
| Domain d1rgba1: 1rgb A:1-133 [118769] automatically matched to d1vpi__ complexed with eld |
| Domain d1rgbb1: 1rgb B:1-133 [118770] automatically matched to d1vpi__ complexed with eld |
| Domain d1rgbk1: 1rgb K:1-133 [118771] automatically matched to d1vpi__ complexed with eld |
| Domain d1rgbl1: 1rgb L:1-133 [118772] automatically matched to d1vpi__ complexed with eld |
| Domain d1vpia_: 1vpi A: [19559] |
| Saw-scaled viper (Echis carinatus) [TaxId:40353] [101486] (1 PDB entry) |
| Domain d1oz6a_: 1oz6 A: [93805] complexed with ca |
| Siamese russell's viper (Daboia russelli siamensis), RV4 catalytic subunit [TaxId:343250] [101485] (1 PDB entry) |
| Domain d1oqsb_: 1oqs B: [93428] |
| Domain d1oqsd_: 1oqs D: [93430] |
| Domain d1oqsf_: 1oqs F: [93432] |
| Domain d1oqsh_: 1oqs H: [93434] complex with inhibitory subunit |
| Siamese russell's viper (Daboia russelli siamensis), RV7 inhibitory subunit [TaxId:343250] [101484] (1 PDB entry) |
| Domain d1oqsa_: 1oqs A: [93427] |
| Domain d1oqsc_: 1oqs C: [93429] |
| Domain d1oqse_: 1oqs E: [93431] |
| Domain d1oqsg_: 1oqs G: [93433] complex with catalytic subunit |
| Small-eye snake (Micropechis ikaheka), different isoforms [TaxId:66188] [110033] (2 PDB entries) |
| Domain d1ozya_: 1ozy A: [104047] |
| Domain d1ozyb_: 1ozy B: [104048] complexed with so4 |
| Domain d1p7oa_: 1p7o A: [104076] |
| Domain d1p7ob_: 1p7o B: [104077] |
| Domain d1p7oc_: 1p7o C: [104078] |
| Domain d1p7od_: 1p7o D: [104079] |
| Domain d1p7oe_: 1p7o E: [104080] |
| Domain d1p7of_: 1p7o F: [104081] |
| Snake (Agkistrodon halys) [TaxId:8714] [48628] (9 PDB entries) |
| Domain d1a2aa_: 1a2a A: [19540] |
| Domain d1a2ab_: 1a2a B: [19541] |
| Domain d1a2ac_: 1a2a C: [19542] |
| Domain d1a2ad_: 1a2a D: [19543] |
| Domain d1a2ae_: 1a2a E: [19544] |
| Domain d1a2af_: 1a2a F: [19545] |
| Domain d1a2ag_: 1a2a G: [19546] |
| Domain d1a2ah_: 1a2a H: [19547] complexed with cl |
| Domain d1b4wa_: 1b4w A: [19536] |
| Domain d1b4wb_: 1b4w B: [19537] |
| Domain d1b4wc_: 1b4w C: [19538] |
| Domain d1b4wd_: 1b4w D: [19539] |
| Domain d1bjja_: 1bjj A: [19530] |
| Domain d1bjjb_: 1bjj B: [19531] |
| Domain d1bjjc_: 1bjj C: [19532] |
| Domain d1bjjd_: 1bjj D: [19533] |
| Domain d1bjje_: 1bjj E: [19534] |
| Domain d1bjjf_: 1bjj F: [19535] complexed with ca |
| Domain d1bk9a_: 1bk9 A: [19527] complexed with bu1, ca, pbp |
| Domain d1c1ja_: 1c1j A: [70061] |
| Domain d1c1jb_: 1c1j B: [70062] |
| Domain d1c1jc_: 1c1j C: [70063] |
| Domain d1c1jd_: 1c1j D: [70064] complexed with bog, cd |
| Domain d1jiaa_: 1jia A: [19528] |
| Domain d1jiab_: 1jia B: [19529] complexed with ca |
| Domain d1m8ra_: 1m8r A: [78812] complexed with bu1, cd |
| Domain d1m8sa_: 1m8s A: [78813] complexed with bu1, cd |
| Domain d1psja_: 1psj A: [19526] complexed with ca |
| Snake (Bothrops pirajai), piratoxin III [TaxId:113192] [69123] (1 PDB entry) |
| Domain d1gmza_: 1gmz A: [65356] |
| Domain d1gmzb_: 1gmz B: [65357] complexed with ioh |
| Snake (Daboia russellii pulchella), different isoforms [TaxId:97228] [48630] (47 PDB entries) |
| Domain d1cl5a_: 1cl5 A: [19551] |
| Domain d1cl5b_: 1cl5 B: [19552] complexed with vitamin E |
| Domain d1fb2a_: 1fb2 A: [59758] |
| Domain d1fb2b_: 1fb2 B: [59759] |
| Domain d1fv0a_: 1fv0 A: [70147] |
| Domain d1fv0b_: 1fv0 B: [70148] complexed with aristolochic acid complexed with 9ar, act, cry, dox, so4 |
| Domain d1jq8a_: 1jq8 A: [77147] |
| Domain d1jq8b_: 1jq8 B: [77148] complexed with a designed peptide inhibitor, chain P complexed with acy, so4 |
| Domain d1jq9a_: 1jq9 A: [77149] |
| Domain d1jq9b_: 1jq9 B: [77150] complexed with a designed peptide inhibitor, chain P complexed with acy |
| Domain d1kpma_: 1kpm A: [72844] |
| Domain d1kpmb_: 1kpm B: [72845] complexed with vitamin E complexed with acy, vit |
| Domain d1oxla_: 1oxl A: [93702] |
| Domain d1oxlb_: 1oxl B: [93703] complexed with co3, ida, so4 |
| Domain d1oyfa_: 1oyf A: [87595] |
| Domain d1oyfb_: 1oyf B: [87596] complexed with acy, mhn, so4 |
| Domain d1q6va_: 1q6v A: [95999] complexed with so4 |
| Domain d1q7aa_: 1q7a A: [96025] complexed with moh, opb, so4 |
| Domain d1skga_: 1skg A: [98901] complexed with moh, so4 |
| Domain d1sqza_: 1sqz A: [98975] complexed with cbz, so4 |
| Domain d1sv3a_: 1sv3 A: [99015] complexed with ann, so4 |
| Domain d1sv9a_: 1sv9 A: [99021] complexed with dif |
| Domain d1sxka_: 1sxk A: [99027] complexed with bha, so4 |
| Domain d1tdva_: 1tdv A: [106786] complexed with so4 |
| Domain d1tg1a_: 1tg1 A: [106888] complexed with acy, cbz, moh, so4 |
| Domain d1tg4a_: 1tg4 A: [106889] complexed with so4 |
| Domain d1tgma_: 1tgm A: [106900] complexed with ain, ca, so4 |
| Domain d1th6a_: 1th6 A: [106907] complexed with oin, so4 |
| Domain d1tj9a_: 1tj9 A: [107015] complexed with acy, so4 |
| Domain d1tjka_: 1tjk A: [107026] complexed with so4 |
| Domain d1tjqa_: 1tjq A: [107049] complexed with cbz, moh, so4 |
| Domain d1tk4a_: 1tk4 A: [107073] complexed with so4 |
| Domain d1tp2a_: 1tp2 A: [107181] |
| Domain d1tp2b_: 1tp2 B: [107182] complexed with acy, so4, tda |
| Domain d1y38a1: 1y38 A:1-133 [122580] automatically matched to d1cl5a_ complexed with g3p, na, pge, so4 |
| Domain d1y38b1: 1y38 B:1-133 [122581] automatically matched to d1cl5a_ complexed with g3p, na, pge, so4 |
| Domain d1zr8a1: 1zr8 A:1-133 [125528] automatically matched to d1cl5a_ complexed with acy, ajm, so4 |
| Domain d1zwpa1: 1zwp A:1-133 [125749] automatically matched to d1cl5a_ complexed with moh, nim, so4 |
| Domain d1zyxa1: 1zyx A:1-133 [125870] automatically matched to d1cl5a_ complexed with lcf, so4 |
| Domain d2arma1: 2arm A:1-133 [127208] automatically matched to d1cl5a_ complexed with oin, so4 |
| Domain d2b17a1: 2b17 A:1-133 [127661] automatically matched to d1cl5a_ complexed with dif, so4 |
| Domain d2dpza1: 2dpz A:1-133 [131618] automatically matched to d1cl5a_ complexed with so4, tyl |
| Domain d2dv8a1: 2dv8 A:1-133 [131764] automatically matched to d1cl5a_ complexed with imn, so4 |
| Domain d2fnxa1: 2fnx A:1-133 [133833] automatically matched to d1cl5a_ complexed with so4 |
| Domain d2g58a1: 2g58 A:1-133 [134645] automatically matched to d1cl5a_ complexed with phq, so4 |
| Domain d2gnsa1: 2gns A:1-133 [135416] automatically matched to d1cl5a_ complexed with so4 |
| Domain d2o1na1: 2o1n A:1-133 [138874] automatically matched to d1cl5a_ |
| Domain d2olia1: 2oli A:1-133 [139137] automatically matched to d1cl5a_ complexed with iop |
| Domain d2otfa1: 2otf A:1-133 [139312] automatically matched to d1cl5a_ complexed with 2tn |
| Domain d2otha1: 2oth A:1-133 [139313] automatically matched to d1cl5a_ complexed with ccn, imn, nim |
| Domain d2ouba1: 2oub A:1-133 [139377] automatically matched to d1cl5a_ complexed with 2tn |
| Domain d2oyfa1: 2oyf A:1-133 [139432] automatically matched to d1cl5a_ complexed with acy, iac, so4 |
| Domain d2pb8a1: 2pb8 A:1-133 [139646] automatically matched to d1cl5a_ complexed with act |
| Domain d2pmja1: 2pmj A:1-133 [139741] automatically matched to d1cl5a_ complexed with ccn, cou |
| Domain d2pwsa1: 2pws A:1-133 [139765] automatically matched to d1cl5a_ complexed with ibp |
| Domain d2pyca1: 2pyc A:1-133 [139780] automatically matched to d1cl5a_ complexed with act, ccn, so4 |
| Domain d2q1pa1: 2q1p A:1-133 [139787] automatically matched to d1cl5a_ complexed with pol, so4 |
| Taiwan cobra (Naja naja atra) [TaxId:8656] [48625] (2 PDB entries) |
| Domain d1poaa_: 1poa A: [19514] complexed with ca |
| Domain d1poba_: 1pob A: [19515] |
| Domain d1pobb_: 1pob B: [19516] complexed with ca, gel |
| Terciopelo (Bothrops asper), myotoxin I [TaxId:8722] [48644] (2 PDB entries) |
| Domain d1clpa_: 1clp A: [19615] |
| Domain d1clpb_: 1clp B: [19616] mutant |
| Domain d1y4la1: 1y4l A:1-133 [122624] automatically matched to d1clpa_ complexed with ipa, p33, svr |
| Domain d1y4lb1: 1y4l B:1-133 [122625] automatically matched to d1clpa_ complexed with ipa, p33, svr |
| Viper (Deinagkistrodon acutus) [TaxId:36307] [69122] (1 PDB entry) |
| Domain d1ijla_: 1ijl A: [66163] |
| Domain d1ijlb_: 1ijl B: [66164] complexed with ca, zn |
| Western diamondback rattlesnake (Crotalus atrox) [TaxId:8730] [48627] (1 PDB entry) |
| Domain d1pp2l_: 1pp2 L: [19525] |
| Domain d1pp2r_: 1pp2 R: [19524] |
Timeline for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2: