Lineage for Protein: Snake phospholipase A2

  1. Root: SCOP 1.73
  2. 631650Class a: All alpha proteins [46456] (258 folds)
  3. 649171Fold a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
    common core: 2 helices, disulfide-linked, and a calcium-binding loop
  4. 649172Superfamily a.133.1: Phospholipase A2, PLA2 [48619] (3 families) (S)
  5. 649177Family a.133.1.2: Vertebrate phospholipase A2 [48623] (2 proteins)
  6. 649265Protein Snake phospholipase A2 [48624] (35 species)

Species:

  1. 649266Bothrops pirajai, Piratoxin-II (PRTX-II) [TaxId:113192] [48633] (1 PDB entry)
  2. 649269Broad-banded copperhead (Agkistrodon contortrix laticinctus) [TaxId:37195] [101483] (3 PDB entries)
    1. Domain for 1s8g:
    2. Domain for 1s8h:
    3. Domain for 1s8i:
  3. 649273Cerrophidion godmani, formerly Bothrops godmani [TaxId:44722] [48645] (1 PDB entry)
    Monomeric Lys-49 phospholipase A2 homologue
  4. 649275Eastern cottonmouth snake (Agkistrodon piscivorus piscivorus) [TaxId:8716] [48629] (2 PDB entries)
    1. Domain for 1ppa:
    2. Domains for 1vap:
      1. 649276Domain d1vapa_: 1vap A: [19548]
      2. 649277Domain d1vapb_: 1vap B: [19549]
  5. 649279Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [74796] (2 PDB entries)
    monomeric Lys-49 phospholipase A2 homologue
    1. Domain for 1mc2:
    2. Domain for 1mg6:
  6. 649282Indian cobra (Naja naja sagittifera), acidic isoform 1 [TaxId:195058] [89168] (1 PDB entry)
  7. 649284Indian cobra (Naja naja sagittifera), calcium-free isoform 5 [TaxId:195058] [89172] (2 PDB entries)
    1. Domain for 1mh7:
    2. Domain for 1mh8:
      • 649285Domain d1mh8a_: 1mh8 A: [84963]
        possibly another isoform with isoleucine at second position
  8. 649287Indian cobra (Naja naja sagittifera), isoform 2 [TaxId:195058] [89169] (2 PDB entries)
    heterodimer of two different isoforms
    1. Domain for 1mh2:
      • 649289Domain d1mh2a_: 1mh2 A: [84960]
        zinc containing heterodimer of two different isoforms
        complexed with acy, zn
    2. Domain for 1s6b:
      • 649288Domain d1s6ba_: 1s6b A: [98592]
        heterodimer of two different isoforms
        complexed with acy, ca, po4
  9. 649290Indian cobra (Naja naja sagittifera), isoform 3 [TaxId:195058] [89170] (2 PDB entries)
    heterodimer of two different isoforms
    1. Domain for 1mh2:
      • 649292Domain d1mh2b_: 1mh2 B: [84961]
        zinc containing heterodimer of two different isoforms
        complexed with acy, zn
    2. Domain for 1s6b:
      • 649291Domain d1s6bb_: 1s6b B: [98593]
        heterodimer of two different isoforms
        complexed with acy, ca, po4
  10. 649293Indian cobra (Naja naja sagittifera), isoform 4 [TaxId:195058] [89171] (7 PDB entries)
    1. Domain for 1ln8:
    2. Domain for 1mf4:
      • 649296Domain d1mf4a_: 1mf4 A: [91261]
        complexed with a designed peptide inhibitor
        complexed with ca
    3. Domain for 1oxr:
    4. Domain for 1t37:
    5. Domain for 1td7:
    6. Domain for 1yxl:
    7. Domain for 1zm6:
  11. 649301Indian cobra (Naja naja) [TaxId:35670] [48626] (4 PDB entries)
    1. Domain for 1a3d:
    2. Domains for 1a3f:
      1. 649306Domain d1a3fa_: 1a3f A: [19521]
      2. 649307Domain d1a3fb_: 1a3f B: [19522]
      3. 649308Domain d1a3fc_: 1a3f C: [19523]
    3. Domains for 1psh:
      1. 649303Domain d1psha_: 1psh A: [19518]
      2. 649304Domain d1pshb_: 1psh B: [19519]
      3. 649305Domain d1pshc_: 1psh C: [19520]
        complexed with ca
    4. Domains for 1xxw:
      1. 649309Domain d1xxwa1: 1xxw A:1-120 [122431]
        automatically matched to d1a3d__
        complexed with acy, zn
      2. 649310Domain d1xxwb1: 1xxw B:1-119 [122432]
        automatically matched to d1a3d__
        complexed with acy, zn
  12. 649311Indian cobra (Naja naja), a C49 isoform 2 [TaxId:35670] [89166] (1 PDB entry)
    • Domain for 1ows:
      • 649312Domain d1owsa_: 1ows A: [87491]
        zinc containing heterodimer of two different isoforms
        complexed with nag, zn
  13. 649313Indian cobra (Naja naja), isoform 3 [TaxId:35670] [89167] (1 PDB entry)
    • Domain for 1ows:
      • 649314Domain d1owsb_: 1ows B: [87492]
        zinc containing heterodimer of two different isoforms
        complexed with nag, zn
  14. 649315Indian krait (Bungarus caeruleus), different isoforms [TaxId:132961] [48636] (8 PDB entries)
    1. Domain for 1dpy:
    2. Domain for 1fe5:
    3. Domains for 1g0z:
      1. 649316Domain d1g0za_: 1g0z A: [83263]
      2. 649317Domain d1g0zb_: 1g0z B: [83264]
        complexed with cl; mutant
    4. Domains for 1g2x:
      1. 649322Domain d1g2xa_: 1g2x A: [83265]
      2. 649323Domain d1g2xb_: 1g2x B: [83266]
      3. 649324Domain d1g2xc_: 1g2x C: [83267]
        trimeric isoform
    5. Domain for 1po8:
    6. Domain for 1tc8:
    7. Domains for 1u4j:
      1. 649318Domain d1u4ja_: 1u4j A: [107673]
      2. 649319Domain d1u4jb_: 1u4j B: [107674]
        complexed with acy, cl, man, na
    8. Domain for 2osn:
  15. 649328Jararacussu (Bothrops jararacussu) [TaxId:8726] [101487] (4 PDB entries)
    1. Domains for 1u73:
      1. 649332Domain d1u73a_: 1u73 A: [113075]
      2. 649333Domain d1u73b_: 1u73 B: [113076]
    2. Domain for 1umv:
      • 649331Domain d1umvx_: 1umv X: [99630]
        acidic, non-myotoxic phospholipase A2
        complexed with ca
    3. Domain for 1zl7:
    4. Domain for 1zlb:
  16. 649334King cobra (Ophiophagus hannah) [TaxId:8665] [81939] (1 PDB entry)
  17. 649338King cobra (Ophiophagus hannah), an acidic isoform [TaxId:8665] [101482] (1 PDB entry)
  18. 649345Mainland tiger snake (Notechis scutatus scutatus), notechis II-5 [TaxId:8663] [48632] (1 PDB entry)
    neurotoxic phospholipase a2
  19. 649348Mainland tiger snake (Notechis scutatus scutatus), notexin [TaxId:8663] [48631] (1 PDB entry)
    presynaptic neurotoxic phospholipase A2
  20. 649350Many-banded krait (Bungarus multicinctus), beta2-bungarotoxin [TaxId:8616] [48642] (1 PDB entry)
  21. 649352Neuwied's lancehead (Bothrops neuwiedi pauloensis), different isoforms [TaxId:95649] [110032] (2 PDB entries)
    1. Domains for 1pa0:
      1. 649353Domain d1pa0a_: 1pa0 A: [104097]
      2. 649354Domain d1pa0b_: 1pa0 B: [104098]
    2. Domains for 1pc9:
      1. 649355Domain d1pc9a_: 1pc9 A: [104107]
      2. 649356Domain d1pc9b_: 1pc9 B: [104108]
  22. 649357Russell's viper (Vipera russelli) [TaxId:8707] [48634] (1 PDB entry)
    anticoagulant class II phospholipase A2
  23. 649359Sand viper (Vipera ammodytes meridionalis), vipoxin catalytic subunit [TaxId:8704] [88518] (2 PDB entries)
    1. Domain for 1aok:
      • 649361Domain d1aokb_: 1aok B: [19561]
        complex with inhibitory subunit
        complexed with act
    2. Domain for 1jlt:
      • 649360Domain d1jltb_: 1jlt B: [66868]
        complex with inhibitory subunit
        complexed with mpd
  24. 649362Sand viper (Vipera ammodytes meridionalis), vipoxin inhibitor [TaxId:8704] [88517] (5 PDB entries)
    1. Domain for 1aok:
      • 649365Domain d1aoka_: 1aok A: [19560]
        complex with catalytic subunit
        complexed with act
    2. Domain for 1jlt:
      • 649363Domain d1jlta_: 1jlt A: [66867]
        complex with catalytic subunit
        complexed with mpd
    3. Domains for 1q5t:
      1. 649366Domain d1q5ta_: 1q5t A: [95932]
      2. 649367Domain d1q5tb_: 1q5t B: [95933]
        complexed with so4
    4. Domains for 1rgb:
      1. 649368Domain d1rgba1: 1rgb A:1-133 [118769]
        automatically matched to d1vpi__
        complexed with eld
      2. 649369Domain d1rgbb1: 1rgb B:1-133 [118770]
        automatically matched to d1vpi__
        complexed with eld
      3. 649370Domain d1rgbk1: 1rgb K:1-133 [118771]
        automatically matched to d1vpi__
        complexed with eld
      4. 649371Domain d1rgbl1: 1rgb L:1-133 [118772]
        automatically matched to d1vpi__
        complexed with eld
    5. Domain for 1vpi:
  25. 649372Saw-scaled viper (Echis carinatus) [TaxId:40353] [101486] (1 PDB entry)
  26. 649374Siamese russell's viper (Daboia russelli siamensis), RV4 catalytic subunit [TaxId:343250] [101485] (1 PDB entry)
  27. 649379Siamese russell's viper (Daboia russelli siamensis), RV7 inhibitory subunit [TaxId:343250] [101484] (1 PDB entry)
  28. 649384Small-eye snake (Micropechis ikaheka), different isoforms [TaxId:66188] [110033] (2 PDB entries)
    1. Domains for 1ozy:
      1. 649391Domain d1ozya_: 1ozy A: [104047]
      2. 649392Domain d1ozyb_: 1ozy B: [104048]
        complexed with so4
    2. Domains for 1p7o:
      1. 649385Domain d1p7oa_: 1p7o A: [104076]
      2. 649386Domain d1p7ob_: 1p7o B: [104077]
      3. 649387Domain d1p7oc_: 1p7o C: [104078]
      4. 649388Domain d1p7od_: 1p7o D: [104079]
      5. 649389Domain d1p7oe_: 1p7o E: [104080]
      6. 649390Domain d1p7of_: 1p7o F: [104081]
  29. 649393Snake (Agkistrodon halys) [TaxId:8714] [48628] (9 PDB entries)
    1. Domains for 1a2a:
      1. 649414Domain d1a2aa_: 1a2a A: [19540]
      2. 649415Domain d1a2ab_: 1a2a B: [19541]
      3. 649416Domain d1a2ac_: 1a2a C: [19542]
      4. 649417Domain d1a2ad_: 1a2a D: [19543]
      5. 649418Domain d1a2ae_: 1a2a E: [19544]
      6. 649419Domain d1a2af_: 1a2a F: [19545]
      7. 649420Domain d1a2ag_: 1a2a G: [19546]
      8. 649421Domain d1a2ah_: 1a2a H: [19547]
        complexed with cl
    2. Domains for 1b4w:
      1. 649400Domain d1b4wa_: 1b4w A: [19536]
      2. 649401Domain d1b4wb_: 1b4w B: [19537]
      3. 649402Domain d1b4wc_: 1b4w C: [19538]
      4. 649403Domain d1b4wd_: 1b4w D: [19539]
    3. Domains for 1bjj:
      1. 649404Domain d1bjja_: 1bjj A: [19530]
      2. 649405Domain d1bjjb_: 1bjj B: [19531]
      3. 649406Domain d1bjjc_: 1bjj C: [19532]
      4. 649407Domain d1bjjd_: 1bjj D: [19533]
      5. 649408Domain d1bjje_: 1bjj E: [19534]
      6. 649409Domain d1bjjf_: 1bjj F: [19535]
        complexed with ca
    4. Domain for 1bk9:
    5. Domains for 1c1j:
      1. 649410Domain d1c1ja_: 1c1j A: [70061]
      2. 649411Domain d1c1jb_: 1c1j B: [70062]
      3. 649412Domain d1c1jc_: 1c1j C: [70063]
      4. 649413Domain d1c1jd_: 1c1j D: [70064]
        complexed with bog, cd
    6. Domains for 1jia:
      1. 649398Domain d1jiaa_: 1jia A: [19528]
      2. 649399Domain d1jiab_: 1jia B: [19529]
        complexed with ca
    7. Domain for 1m8r:
    8. Domain for 1m8s:
    9. Domain for 1psj:
  30. 649422Snake (Bothrops pirajai), piratoxin III [TaxId:113192] [69123] (1 PDB entry)
  31. 649425Snake (Daboia russellii pulchella), different isoforms [TaxId:97228] [48630] (47 PDB entries)
    1. Domains for 1cl5:
      1. 649471Domain d1cl5a_: 1cl5 A: [19551]
      2. 649472Domain d1cl5b_: 1cl5 B: [19552]
        complexed with vitamin E
    2. Domains for 1fb2:
      1. 649462Domain d1fb2a_: 1fb2 A: [59758]
      2. 649463Domain d1fb2b_: 1fb2 B: [59759]
    3. Domains for 1fv0:
      1. 649444Domain d1fv0a_: 1fv0 A: [70147]
      2. 649445Domain d1fv0b_: 1fv0 B: [70148]
        complexed with aristolochic acid
        complexed with 9ar, act, cry, dox, so4
    4. Domains for 1jq8:
      1. 649457Domain d1jq8a_: 1jq8 A: [77147]
      2. 649458Domain d1jq8b_: 1jq8 B: [77148]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy, so4
    5. Domains for 1jq9:
      1. 649450Domain d1jq9a_: 1jq9 A: [77149]
      2. 649451Domain d1jq9b_: 1jq9 B: [77150]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy
    6. Domains for 1kpm:
      1. 649452Domain d1kpma_: 1kpm A: [72844]
      2. 649453Domain d1kpmb_: 1kpm B: [72845]
        complexed with vitamin E
        complexed with acy, vit
    7. Domains for 1oxl:
      1. 649448Domain d1oxla_: 1oxl A: [93702]
      2. 649449Domain d1oxlb_: 1oxl B: [93703]
        complexed with co3, ida, so4
    8. Domains for 1oyf:
      1. 649473Domain d1oyfa_: 1oyf A: [87595]
      2. 649474Domain d1oyfb_: 1oyf B: [87596]
        complexed with acy, mhn, so4
    9. Domain for 1q6v:
    10. Domain for 1q7a:
    11. Domain for 1skg:
    12. Domain for 1sqz:
    13. Domain for 1sv3:
    14. Domain for 1sv9:
    15. Domain for 1sxk:
    16. Domain for 1tdv:
    17. Domain for 1tg1:
    18. Domain for 1tg4:
    19. Domain for 1tgm:
    20. Domain for 1th6:
    21. Domain for 1tj9:
    22. Domain for 1tjk:
    23. Domain for 1tjq:
    24. Domain for 1tk4:
    25. Domains for 1tp2:
      1. 649469Domain d1tp2a_: 1tp2 A: [107181]
      2. 649470Domain d1tp2b_: 1tp2 B: [107182]
        complexed with acy, so4, tda
    26. Domains for 1y38:
      1. 649475Domain d1y38a1: 1y38 A:1-133 [122580]
        automatically matched to d1cl5a_
        complexed with g3p, na, pge, so4
      2. 649476Domain d1y38b1: 1y38 B:1-133 [122581]
        automatically matched to d1cl5a_
        complexed with g3p, na, pge, so4
    27. Domain for 1zr8:
    28. Domain for 1zwp:
    29. Domain for 1zyx:
    30. Domain for 2arm:
    31. Domain for 2b17:
    32. Domain for 2dpz:
    33. Domain for 2dv8:
    34. Domain for 2fnx:
    35. Domain for 2g58:
    36. Domain for 2gns:
    37. Domain for 2o1n:
    38. Domain for 2oli:
    39. Domain for 2otf:
    40. Domain for 2oth:
    41. Domain for 2oub:
    42. Domain for 2oyf:
    43. Domain for 2pb8:
    44. Domain for 2pmj:
    45. Domain for 2pws:
    46. Domain for 2pyc:
    47. Domain for 2q1p:
  32. 649483Taiwan cobra (Naja naja atra) [TaxId:8656] [48625] (2 PDB entries)
    1. Domain for 1poa:
    2. Domains for 1pob:
      1. 649485Domain d1poba_: 1pob A: [19515]
      2. 649486Domain d1pobb_: 1pob B: [19516]
        complexed with ca, gel
  33. 649487Terciopelo (Bothrops asper), myotoxin I [TaxId:8722] [48644] (2 PDB entries)
    1. Domains for 1clp:
      1. 649490Domain d1clpa_: 1clp A: [19615]
      2. 649491Domain d1clpb_: 1clp B: [19616]
        mutant
    2. Domains for 1y4l:
      1. 649488Domain d1y4la1: 1y4l A:1-133 [122624]
        automatically matched to d1clpa_
        complexed with ipa, p33, svr
      2. 649489Domain d1y4lb1: 1y4l B:1-133 [122625]
        automatically matched to d1clpa_
        complexed with ipa, p33, svr
  34. 649492Viper (Deinagkistrodon acutus) [TaxId:36307] [69122] (1 PDB entry)
  35. 649495Western diamondback rattlesnake (Crotalus atrox) [TaxId:8730] [48627] (1 PDB entry)

More info for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2

Timeline for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2: