SCOP 1.69: Protein: Snake phospholipase A2

Lineage for Protein: Snake phospholipase A2

Root: SCOP 1.69
Class a: All alpha proteins [46456] (218 folds)
Fold a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
common core: 2 helices, disulfide-linked, and a calcium-binding loop
Superfamily a.133.1: Phospholipase A2, PLA2 [48619] (3 families)
Family a.133.1.2: Vertebrate phospholipase A2 [48623] (2 proteins)
Protein Snake phospholipase A2 [48624] (35 species)

Species:

Bothrops godmani [48645] (1 PDB entry)
Monomeric Lys-49 phospholipase A2 homologue
- Domain for 1god:
  - Domain d1goda_: 1god A: [19617]
Bothrops pirajai, Piratoxin-II (PRTX-II) [TaxId:113192] [48633] (1 PDB entry)
- Domains for 1qll:
  1. Domain d1qlla_: 1qll A: [19556]
  2. Domain d1qllb_: 1qll B: [19557]
Broad-banded copperhead (Agkistrodon contortrix laticinctus) [TaxId:37195] [101483] (3 PDB entries)
1. Domain for 1s8g:
  - Domain d1s8ga_: 1s8g A: [98733]
2. Domain for 1s8h:
  - Domain d1s8ha_: 1s8h A: [98734]
3. Domain for 1s8i:
  - Domain d1s8ia_: 1s8i A: [98735]
Chinese water moccasin (Agkistrodon halys pallas), different isoforms [48628] (9 PDB entries)
1. Domains for 1a2a:
  1. Domain d1a2aa_: 1a2a A: [19540]
  2. Domain d1a2ab_: 1a2a B: [19541]
  3. Domain d1a2ac_: 1a2a C: [19542]
  4. Domain d1a2ad_: 1a2a D: [19543]
  5. Domain d1a2ae_: 1a2a E: [19544]
  6. Domain d1a2af_: 1a2a F: [19545]
  7. Domain d1a2ag_: 1a2a G: [19546]
  8. Domain d1a2ah_: 1a2a H: [19547]
2. Domains for 1b4w:
  1. Domain d1b4wa_: 1b4w A: [19536]
  2. Domain d1b4wb_: 1b4w B: [19537]
  3. Domain d1b4wc_: 1b4w C: [19538]
  4. Domain d1b4wd_: 1b4w D: [19539]
3. Domains for 1bjj:
  1. Domain d1bjja_: 1bjj A: [19530]
  2. Domain d1bjjb_: 1bjj B: [19531]
  3. Domain d1bjjc_: 1bjj C: [19532]
  4. Domain d1bjjd_: 1bjj D: [19533]
  5. Domain d1bjje_: 1bjj E: [19534]
  6. Domain d1bjjf_: 1bjj F: [19535]
4. Domain for 1bk9:
  - Domain d1bk9__: 1bk9 - [19527]
5. Domains for 1c1j:
  1. Domain d1c1ja_: 1c1j A: [70061]
  2. Domain d1c1jb_: 1c1j B: [70062]
  3. Domain d1c1jc_: 1c1j C: [70063]
  4. Domain d1c1jd_: 1c1j D: [70064]
6. Domains for 1jia:
  1. Domain d1jiaa_: 1jia A: [19528]
  2. Domain d1jiab_: 1jia B: [19529]
7. Domain for 1m8r:
  - Domain d1m8ra_: 1m8r A: [78812]
8. Domain for 1m8s:
  - Domain d1m8sa_: 1m8s A: [78813]
9. Domain for 1psj:
  - Domain d1psj__: 1psj - [19526]
Eastern cottonmouth snake (Agkistridon piscivorus) [48629] (2 PDB entries)
1. Domain for 1ppa:
  - Domain d1ppa__: 1ppa - [19550]
2. Domains for 1vap:
  1. Domain d1vapa_: 1vap A: [19548]
  2. Domain d1vapb_: 1vap B: [19549]
Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [74796] (2 PDB entries)
monomeric Lys-49 phospholipase A2 homologue
1. Domain for 1mc2:
  - Domain d1mc2a_: 1mc2 A: [74622]
2. Domain for 1mg6:
  - Domain d1mg6a_: 1mg6 A: [79091]
Indian cobra (Naja naja naja) [48626] (3 PDB entries)
1. Domain for 1a3d:
  - Domain d1a3d__: 1a3d - [19517]
2. Domains for 1a3f:
  1. Domain d1a3fa_: 1a3f A: [19521]
  2. Domain d1a3fb_: 1a3f B: [19522]
  3. Domain d1a3fc_: 1a3f C: [19523]
3. Domains for 1psh:
  1. Domain d1psha_: 1psh A: [19518]
  2. Domain d1pshb_: 1psh B: [19519]
  3. Domain d1pshc_: 1psh C: [19520]
Indian cobra (Naja naja sagittifera), acidic isoform 1 [TaxId:195058] [89168] (1 PDB entry)
- Domain for 1sz8:
  - Domain d1sz8a_: 1sz8 A: [99044]
Indian cobra (Naja naja sagittifera), calcium-free isoform 5 [TaxId:195058] [89172] (2 PDB entries)
1. Domain for 1mh7:
  - Domain d1mh7a_: 1mh7 A: [84962]
2. Domain for 1mh8:
  - Domain d1mh8a_: 1mh8 A: [84963]
    possibly another isoform with isoleucine at second position
Indian cobra (Naja naja sagittifera), isoform 2 [TaxId:195058] [89169] (2 PDB entries)
heterodimer of two different isoforms
1. Domain for 1mh2:
  - Domain d1mh2a_: 1mh2 A: [84960]
    zinc containing heterodimer of two different isoforms
2. Domain for 1s6b:
  - Domain d1s6ba_: 1s6b A: [98592]
    heterodimer of two different isoforms
Indian cobra (Naja naja sagittifera), isoform 3 [TaxId:195058] [89170] (2 PDB entries)
heterodimer of two different isoforms
1. Domain for 1mh2:
  - Domain d1mh2b_: 1mh2 B: [84961]
    zinc containing heterodimer of two different isoforms
2. Domain for 1s6b:
  - Domain d1s6bb_: 1s6b B: [98593]
    heterodimer of two different isoforms
Indian cobra (Naja naja sagittifera), isoform 4 [TaxId:195058] [89171] (5 PDB entries)
1. Domain for 1ln8:
  - Domain d1ln8a_: 1ln8 A: [84634]
2. Domain for 1mf4:
  - Domain d1mf4a_: 1mf4 A: [91261]
    complexed with a designed peptide inhibitor
3. Domain for 1oxr:
  - Domain d1oxra_: 1oxr A: [93714]
    complexed with aspirin
4. Domain for 1t37:
  - Domain d1t37a_: 1t37 A: [99116]
5. Domain for 1td7:
  - Domain d1td7a_: 1td7 A: [106771]
    yet another isoform, 98% identity
Indian cobra (Naja naja), a C49 isoform 2 [TaxId:35670] [89166] (1 PDB entry)
- Domain for 1ows:
  - Domain d1owsa_: 1ows A: [87491]
    zinc containing heterodimer of two different isoforms
Indian cobra (Naja naja), isoform 3 [TaxId:35670] [89167] (1 PDB entry)
- Domain for 1ows:
  - Domain d1owsb_: 1ows B: [87492]
    zinc containing heterodimer of two different isoforms
Indian krait (Bungarus caeruleus), different isoforms [TaxId:132961] [48636] (7 PDB entries)
1. Domain for 1dpy:
  - Domain d1dpya_: 1dpy A: [19562]
2. Domain for 1fe5:
  - Domain d1fe5a_: 1fe5 A: [19563]
3. Domains for 1g0z:
  1. Domain d1g0za_: 1g0z A: [83263]
  2. Domain d1g0zb_: 1g0z B: [83264]
4. Domains for 1g2x:
  1. Domain d1g2xa_: 1g2x A: [83265]
  2. Domain d1g2xb_: 1g2x B: [83266]
  3. Domain d1g2xc_: 1g2x C: [83267]
    trimeric isoform
5. Domain for 1po8:
  - Domain d1po8a_: 1po8 A: [94966]
6. Domain for 1tc8:
  - Domain d1tc8a_: 1tc8 A: [106758]
    74% sequence identity
7. Domains for 1u4j:
  1. Domain d1u4ja_: 1u4j A: [107673]
  2. Domain d1u4jb_: 1u4j B: [107674]
Jararacussu (Bothrops jararacussu) [TaxId:8726] [101487] (1 PDB entry)
- Domain for 1umv:
  - Domain d1umvx_: 1umv X: [99630]
    acidic, non-myotoxic phospholipase A2
King cobra (Ophiophagus hannah) [TaxId:8665] [81939] (1 PDB entry)
- Domains for 1gp7:
  1. Domain d1gp7a_: 1gp7 A: [76251]
  2. Domain d1gp7b_: 1gp7 B: [76252]
  3. Domain d1gp7c_: 1gp7 C: [76253]
King cobra (Ophiophagus hannah), an acidic isoform [TaxId:8665] [101482] (1 PDB entry)
- Domains for 1m8t:
  1. Domain d1m8ta_: 1m8t A: [91227]
  2. Domain d1m8tb_: 1m8t B: [91228]
  3. Domain d1m8tc_: 1m8t C: [91229]
  4. Domain d1m8td_: 1m8t D: [91230]
  5. Domain d1m8te_: 1m8t E: [91231]
  6. Domain d1m8tf_: 1m8t F: [91232]
Mainland tiger snake (Notechis scutatus scutatus), notechis II-5 [TaxId:8663] [48632] (1 PDB entry)
neurotoxic phospholipase a2
- Domains for 2not:
  1. Domain d2nota_: 2not A: [19554]
  2. Domain d2notb_: 2not B: [19555]
Mainland tiger snake (Notechis scutatus scutatus), notexin [TaxId:8663] [48631] (1 PDB entry)
presynaptic neurotoxic phospholipase A2
- Domain for 1ae7:
  - Domain d1ae7__: 1ae7 - [19553]
Many-banded krait (Bungarus multicinctus), beta2-bungarotoxin [TaxId:8616] [48642] (1 PDB entry)
- Domain for 1bun:
  - Domain d1buna_: 1bun A: [19614]
    Other proteins in same PDB: d1bunb_
Neuwied's lancehead (Bothrops neuwiedi pauloensis), different isoforms [TaxId:95649] [110032] (2 PDB entries)
1. Domains for 1pa0:
  1. Domain d1pa0a_: 1pa0 A: [104097]
  2. Domain d1pa0b_: 1pa0 B: [104098]
2. Domains for 1pc9:
  1. Domain d1pc9a_: 1pc9 A: [104107]
  2. Domain d1pc9b_: 1pc9 B: [104108]
Russell's viper (Vipera russelli) [TaxId:8707] [48634] (1 PDB entry)
anticoagulant class II phospholipase A2
- Domain for 1vip:
  - Domain d1vip__: 1vip - [19558]
Sand viper (Vipera ammodytes meridionalis), vipoxin catalytic subunit [TaxId:8704] [88518] (2 PDB entries)
1. Domain for 1aok:
  - Domain d1aokb_: 1aok B: [19561]
    complex with inhibitory subunit
2. Domain for 1jlt:
  - Domain d1jltb_: 1jlt B: [66868]
    complex with inhibitory subunit
Sand viper (Vipera ammodytes meridionalis), vipoxin inhibitor [TaxId:8704] [88517] (4 PDB entries)
1. Domain for 1aok:
  - Domain d1aoka_: 1aok A: [19560]
    complex with catalytic subunit
2. Domain for 1jlt:
  - Domain d1jlta_: 1jlt A: [66867]
    complex with catalytic subunit
3. Domains for 1q5t:
  1. Domain d1q5ta_: 1q5t A: [95932]
  2. Domain d1q5tb_: 1q5t B: [95933]
4. Domain for 1vpi:
  - Domain d1vpi__: 1vpi - [19559]
Saw-scaled viper (Echis carinatus) [TaxId:40353] [101486] (1 PDB entry)
- Domain for 1oz6:
  - Domain d1oz6a_: 1oz6 A: [93805]
Siamese russell's viper (Daboia russelli siamensis), RV4 catalytic subunit [TaxId:343250] [101485] (1 PDB entry)
- Domains for 1oqs:
  1. Domain d1oqsb_: 1oqs B: [93428]
  2. Domain d1oqsd_: 1oqs D: [93430]
  3. Domain d1oqsf_: 1oqs F: [93432]
  4. Domain d1oqsh_: 1oqs H: [93434]
    complex with inhibitory subunit
Siamese russell's viper (Daboia russelli siamensis), RV7 inhibitory subunit [TaxId:343250] [101484] (1 PDB entry)
- Domains for 1oqs:
  1. Domain d1oqsa_: 1oqs A: [93427]
  2. Domain d1oqsc_: 1oqs C: [93429]
  3. Domain d1oqse_: 1oqs E: [93431]
  4. Domain d1oqsg_: 1oqs G: [93433]
    complex with catalytic subunit
Small-eye snake (Micropechis ikaheka), different isoforms [TaxId:66188] [110033] (2 PDB entries)
1. Domains for 1ozy:
  1. Domain d1ozya_: 1ozy A: [104047]
  2. Domain d1ozyb_: 1ozy B: [104048]
2. Domains for 1p7o:
  1. Domain d1p7oa_: 1p7o A: [104076]
  2. Domain d1p7ob_: 1p7o B: [104077]
  3. Domain d1p7oc_: 1p7o C: [104078]
  4. Domain d1p7od_: 1p7o D: [104079]
  5. Domain d1p7oe_: 1p7o E: [104080]
  6. Domain d1p7of_: 1p7o F: [104081]
Snake (Bothrops pirajai), piratoxin III [TaxId:113192] [69123] (1 PDB entry)
Asp-49 phospholipase A2 homologue
- Domains for 1gmz:
  1. Domain d1gmza_: 1gmz A: [65356]
  2. Domain d1gmzb_: 1gmz B: [65357]
Snake (Daboia russelli pulchella) [48630] (26 PDB entries)
1. Domains for 1cl5:
  1. Domain d1cl5a_: 1cl5 A: [19551]
  2. Domain d1cl5b_: 1cl5 B: [19552]
    complexed with vitamin E
2. Domains for 1fb2:
  1. Domain d1fb2a_: 1fb2 A: [59758]
  2. Domain d1fb2b_: 1fb2 B: [59759]
3. Domains for 1fv0:
  1. Domain d1fv0a_: 1fv0 A: [70147]
  2. Domain d1fv0b_: 1fv0 B: [70148]
    complexed with aristolochic acid
4. Domains for 1jq8:
  1. Domain d1jq8a_: 1jq8 A: [77147]
  2. Domain d1jq8b_: 1jq8 B: [77148]
    complexed with a designed peptide inhibitor, chain P
5. Domains for 1jq9:
  1. Domain d1jq9a_: 1jq9 A: [77149]
  2. Domain d1jq9b_: 1jq9 B: [77150]
    complexed with a designed peptide inhibitor, chain P
6. Domains for 1kpm:
  1. Domain d1kpma_: 1kpm A: [72844]
  2. Domain d1kpmb_: 1kpm B: [72845]
    complexed with vitamin E
7. Domains for 1oxl:
  1. Domain d1oxla_: 1oxl A: [93702]
  2. Domain d1oxlb_: 1oxl B: [93703]
8. Domains for 1oyf:
  1. Domain d1oyfa_: 1oyf A: [87595]
  2. Domain d1oyfb_: 1oyf B: [87596]
9. Domain for 1q6v:
  - Domain d1q6va_: 1q6v A: [95999]
10. Domain for 1q7a:
  - Domain d1q7aa_: 1q7a A: [96025]
11. Domain for 1skg:
  - Domain d1skga_: 1skg A: [98901]
12. Domain for 1sqz:
  - Domain d1sqza_: 1sqz A: [98975]
13. Domain for 1sv3:
  - Domain d1sv3a_: 1sv3 A: [99015]
14. Domain for 1sv9:
  - Domain d1sv9a_: 1sv9 A: [99021]
15. Domain for 1sxk:
  - Domain d1sxka_: 1sxk A: [99027]
16. Domain for 1tdv:
  - Domain d1tdva_: 1tdv A: [106786]
17. Domain for 1tg1:
  - Domain d1tg1a_: 1tg1 A: [106888]
18. Domain for 1tg4:
  - Domain d1tg4a_: 1tg4 A: [106889]
19. Domain for 1tgm:
  - Domain d1tgma_: 1tgm A: [106900]
20. Domain for 1th6:
  - Domain d1th6a_: 1th6 A: [106907]
21. Domain for 1ti0:
  - Domain d1ti0a_: 1ti0 A: [106925]
22. Domain for 1tj9:
  - Domain d1tj9a_: 1tj9 A: [107015]
    different isoforms
23. Domain for 1tjk:
  - Domain d1tjka_: 1tjk A: [107026]
24. Domain for 1tjq:
  - Domain d1tjqa_: 1tjq A: [107049]
25. Domain for 1tk4:
  - Domain d1tk4a_: 1tk4 A: [107073]
26. Domains for 1tp2:
  1. Domain d1tp2a_: 1tp2 A: [107181]
  2. Domain d1tp2b_: 1tp2 B: [107182]
Taiwan cobra (Naja naja atra) [TaxId:8656] [48625] (2 PDB entries)
1. Domain for 1poa:
  - Domain d1poa__: 1poa - [19514]
2. Domains for 1pob:
  1. Domain d1poba_: 1pob A: [19515]
  2. Domain d1pobb_: 1pob B: [19516]
Terciopelo (Bothrops asper), myotoxin I [TaxId:8722] [48644] (1 PDB entry)
- Domains for 1clp:
  1. Domain d1clpa_: 1clp A: [19615]
  2. Domain d1clpb_: 1clp B: [19616]
Viper (Deinagkistrodon acutus) [TaxId:36307] [69122] (1 PDB entry)
- Domains for 1ijl:
  1. Domain d1ijla_: 1ijl A: [66163]
  2. Domain d1ijlb_: 1ijl B: [66164]
Western diamondback rattlesnake (Crotalus atrox) [TaxId:8730] [48627] (1 PDB entry)
- Domains for 1pp2:
  1. Domain d1pp2l_: 1pp2 L: [19525]
  2. Domain d1pp2r_: 1pp2 R: [19524]

More info for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2

Timeline for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2:

Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2 first appeared (with stable ids) in SCOP 1.55
Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2 appears in SCOP 1.67
Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2 appears in SCOP 1.71
Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2 appears in the current release, SCOPe 2.08