SCOP 1.75: Family a.123.1.1: Nuclear receptor ligand-binding domain

Lineage for Family a.123.1.1: Nuclear receptor ligand-binding domain

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (1 family)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (33 proteins)

Proteins:

1. Androgen receptor [63621] (3 species)

   1. Species Chimpanzee (Pan troglodytes) [TaxId:9598] [109986] (8 PDB entries)
      Uniprot O97775 661-910 # 100% sequence identity to human sequence (Uniprot P10275 669-918)

   2. Species Human (Homo sapiens) [TaxId:9606] [63623] (36 PDB entries)
      Uniprot P10275 671-919

   3. Species Rat (Rattus norvegicus) [TaxId:10116] [63622] (7 PDB entries)

2. Bile acid receptor FXR [101433] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [101434] (4 PDB entries)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [101435] (2 PDB entries)

3. Ecdysone receptor [101436] (1 species)

   • Species Noctuid moth (Heliothis virescens) [TaxId:7102] [101437] (3 PDB entries)

4. Estrogen receptor alpha [48519] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [48520] (29 PDB entries)
     Uniprot P03372 307-551

5. Estrogen receptor beta [48521] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [48522] (19 PDB entries)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [48523] (4 PDB entries)

6. Glucocorticoid receptor [89140] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89141] (4 PDB entries)

7. Hepatocyte nuclear factor 4-alpha [109605] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [109987] (1 PDB entry)
      Uniprot P41235 139-369

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [89146] (1 PDB entry)

8. Hepatocyte nuclear factor 4-gamma [81918] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [81919] (1 PDB entry)

9. Nuclear hormone receptor HR38 [89144] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [89145] (1 PDB entry)

10. Orphan nuclear receptor ERR3 [81916] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [81917] (16 PDB entries)
      Uniprot O75454 233-458

11. Orphan nuclear receptor NR1I3 (CAR) [117014] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [117016] (2 PDB entries)
       Uniprot Q14994 103-352

    2. Species Mouse (Mus musculus) [TaxId:10090] [117015] (2 PDB entries)
       Uniprot O35627 109-358

12. Orphan nuclear receptor NR4A1 [158811] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [158812] (1 PDB entry)
      Uniprot P22736 363-595

13. Orphan nuclear receptor NR5a2 (LRH-1) [89147] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [89148] (1 PDB entry)

14. Orphan nuclear receptor NURR1 [89142] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89143] (1 PDB entry)

15. Orphan nuclear receptor ROR-alpha [81914] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [81915] (2 PDB entries)

16. Orphan nuclear receptor ROR-beta [74794] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [74795] (3 PDB entries)

17. Oxysterols receptor LXR-alpha [109988] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [109989] (1 PDB entry)
       Uniprot Q13133 207-445

    2. Species Mouse (Mus musculus) [TaxId:10090] [158810] (1 PDB entry)
       Uniprot Q9Z0Y9 203-443

18. Oxysterols receptor LXR-beta [89149] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89150] (6 PDB entries)
      Uniprot P55055 219-461

19. Peroxisome proliferator activated receptor alpha, PPAR-alpha [69109] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [69110] (5 PDB entries)

20. Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48525] (46 PDB entries)
      Uniprot P37231 232-505

21. Peroxisome proliferator-activated receptor delta, PPAR-DELTA [48526] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48527] (11 PDB entries)

22. Pregnane x receptor, PXR [63624] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63625] (6 PDB entries)

23. Progesterone receptor [48517] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48518] (7 PDB entries)
      Uniprot P06401 679-932

24. Retinoic acid receptor alpha (RAR-alpha) [48513] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48514] (1 PDB entry)

25. Retinoic acid receptor beta (RAR-beta) [117011] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [117013] (1 PDB entry)
       Uniprot P10826 182-416

    2. Species Mouse (Mus musculus) [TaxId:10090] [117012] (1 PDB entry)
       Uniprot P22605 209-453

26. Retinoic acid receptor gamma (RAR-gamma) [48515] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48516] (9 PDB entries)

27. Retinoid-X receptor alpha (RXR-alpha) [48510] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [48511] (18 PDB entries)
       Uniprot P19793 227-458

    2. Species Mouse (Mus musculus) [TaxId:10090] [48512] (2 PDB entries)
       Uniprot P28700 232-463

28. Retinoid-X receptor beta (RXR-beta) [74792] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74793] (2 PDB entries)
      Uniprot P28702 298-528

29. Steroid hormone receptor ERR1 [109990] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [109991] (2 PDB entries)
      Uniprot P11474 289-516

30. Thyroid hormone receptor alpha1 (TR-alpha1) [48532] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [88962] (1 PDB entry)

31. Thyroid hormone receptor beta (TR-beta) [48530] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48531] (11 PDB entries)
      Uniprot P10828 202-460

32. Ultraspiracle protein, usp [48534] (2 species)
    the ortholog of RXRs in insects

    1. Species Drosophila melanogaster [TaxId:7227] [48535] (1 PDB entry)

    2. Species Heliothis virescens [TaxId:7102] [63626] (4 PDB entries)

33. Vitamin D nuclear receptor [48528] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [48529] (13 PDB entries)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [101432] (12 PDB entries)

More info for Family a.123.1.1: Nuclear receptor ligand-binding domain

Timeline for Family a.123.1.1: Nuclear receptor ligand-binding domain:

• Family a.123.1.1: Nuclear receptor ligand-binding domain first appeared (with stable ids) in SCOP 1.55
  
• Family a.123.1.1: Nuclear receptor ligand-binding domain appears in SCOP 1.73
  
• Family a.123.1.1: Nuclear receptor ligand-binding domain appears in SCOPe 2.01
  
• Family a.123.1.1: Nuclear receptor ligand-binding domain appears in the current release, SCOPe 2.08