SCOP 1.65: Family a.123.1.1: Nuclear receptor ligand-binding domain

Lineage for Family a.123.1.1: Nuclear receptor ligand-binding domain

1. Root: SCOP 1.65

2. Class a: All alpha proteins [46456] (179 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (1 family)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (25 proteins)

Proteins:

1. Androgen receptor [63621] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [63623] (1 PDB entry)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [63622] (3 PDB entries)

2. Estrogen receptor alpha [48519] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [48520] (12 PDB entries)

3. Estrogen receptor beta [48521] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [48522] (3 PDB entries)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [48523] (2 PDB entries)

4. Glucocorticoid receptor [89140] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89141] (3 PDB entries)

5. Hepatocyte nuclear factor 4-gamma [81918] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [81919] (1 PDB entry)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [89146] (1 PDB entry)

6. Nuclear hormone receptor HR38 [89144] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [89145] (1 PDB entry)

7. Orphan nuclear receptor ERR3 [81916] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [81917] (1 PDB entry)

8. Orphan nuclear receptor NR5a2 (LRH-1) [89147] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [89148] (1 PDB entry)

9. Orphan nuclear receptor NURR1 [89142] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89143] (1 PDB entry)

10. Orphan nuclear receptor ROR-alpha [81914] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [81915] (1 PDB entry)

11. Orphan nuclear receptor ROR-beta [74794] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [74795] (1 PDB entry)

12. Oxysterols receptor LXR-beta [89149] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89150] (1 PDB entry)

13. Peroxisome proliferator activated receptor alpha, PPAR-alpha [69109] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [69110] (3 PDB entries)

14. Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48525] (10 PDB entries)

15. Peroxisome proliferator-activated receptor delta, PPAR-DELTA [48526] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48527] (3 PDB entries)

16. Pregnane x receptor, PXR [63624] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63625] (3 PDB entries)

17. Progesterone receptor [48517] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48518] (2 PDB entries)

18. Retinoic acid receptor alpha (RAR-alpha) [48513] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48514] (1 PDB entry)

19. Retinoic acid receptor gamma (RAR-gamma) [48515] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48516] (9 PDB entries)

20. Retinoid-X receptor alpha (RXR-alpha) [48510] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [48511] (10 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [48512] (1 PDB entry)

21. Retinoid-X receptor beta (RXR-beta) [74792] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74793] (1 PDB entry)

22. Thyroid hormone receptor alpha1 (TR-alpha1) [48532] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [88962] (1 PDB entry)

23. Thyroid hormone receptor beta (TR-beta) [48530] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48531] (7 PDB entries)

24. Ultraspiracle protein, usp [48534] (2 species)
    the ortholog of RXRs in insects

    1. Species Drosophila melanogaster [TaxId:7227] [48535] (1 PDB entry)

    2. Species Heliothis virescens [TaxId:7102] [63626] (1 PDB entry)

25. Vitamin D nuclear receptor [48528] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [48529] (3 PDB entries)

More info for Family a.123.1.1: Nuclear receptor ligand-binding domain

Timeline for Family a.123.1.1: Nuclear receptor ligand-binding domain:

• Family a.123.1.1: Nuclear receptor ligand-binding domain first appeared (with stable ids) in SCOP 1.55
  
• Family a.123.1.1: Nuclear receptor ligand-binding domain appears in SCOP 1.63
  
• Family a.123.1.1: Nuclear receptor ligand-binding domain appears in SCOP 1.67
  
• Family a.123.1.1: Nuclear receptor ligand-binding domain appears in the current release, SCOPe 2.08