SCOPe 2.06: Family a.104.1.1: Cytochrome P450

Lineage for Family a.104.1.1: Cytochrome P450

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.1: Cytochrome P450 [48265] (23 proteins)

Proteins:

1. Cyp119 [48278] (3 species)
   thermophilic P450

   1. Species Sulfolobus acidocaldarius [TaxId:330779] [311443] (4 PDB entries)

   2. Species Sulfolobus solfataricus [TaxId:2287] [48279] (6 PDB entries)

   3. Species Sulfolobus tokodaii [TaxId:111955] [109957] (2 PDB entries)
      Uniprot Q972I2

2. Cyp121 monooxygenase (P450 Mt2) [81865] (2 species)

   1. Species Mycobacterium bovis [TaxId:233413] [313826] (1 PDB entry)

   2. Species Mycobacterium tuberculosis [TaxId:1773] [81866] (35 PDB entries)

3. Cyp154a1 monooxygenase [101373] (1 species)

   • Species Streptomyces coelicolor [TaxId:1902] [101374] (1 PDB entry)

4. Cyp154c1 monooxygenase [81867] (1 species)
   functionalizes macrolide ring systems

   • Species Streptomyces coelicolor [TaxId:1902] [81868] (1 PDB entry)

5. Cyp158a2 [116991] (1 species)

   • Species Streptomyces coelicolor [TaxId:1902] [116992] (1 PDB entry)
     Uniprot Q9FCA6

6. Cyp175a1 [81869] (1 species)
   thermostable P450

   • Species Thermus thermophilus [TaxId:274] [81870] (2 PDB entries)
     Uniprot Q53W59

7. Cytochrome p450 14 alpha-sterol demethylase (cyp51) [48276] (1 species)

   • Species Mycobacterium tuberculosis [TaxId:1773] [48277] (5 PDB entries)
     Uniprot P0A512 P77901

8. Cytochrome p450 152a1 (Bs-beta) [89116] (1 species)

   • Species Bacillus subtilis [TaxId:1423] [89117] (1 PDB entry)

9. Cytochrome P450 bm-3 [48268] (2 species)

   1. Species Bacillus megaterium [TaxId:1348623] [342557] (1 PDB entry)

   2. Species Bacillus megaterium [TaxId:1404] [48269] (76 PDB entries)
      Uniprot P14779

10. Cytochrome P450-CAM [48266] (1 species)

    • Species Pseudomonas putida [TaxId:303] [48267] (115 PDB entries)
      Uniprot P00183

11. Cytochrome P450-ERYF [48272] (1 species)

    • Species Saccharopolyspora erythraea [TaxId:1836] [48273] (10 PDB entries)

12. Cytochrome P450-NOR, nitric reductase [48270] (1 species)

    • Species Fungus (Fusarium oxysporum) [TaxId:5507] [48271] (25 PDB entries)
      Uniprot P23295

13. Cytochrome P450-TERP [48274] (1 species)

    • Species Pseudomonas sp. [TaxId:306] [48275] (1 PDB entry)

14. Cytochrome P450epok [101369] (1 species)

    • Species Sorangium cellulosum [TaxId:56] [101370] (3 PDB entries)

15. Mammalian cytochrome p450 2b4 [101375] (1 species)

    • Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [101376] (10 PDB entries)
      Uniprot P00178

16. Mammalian cytochrome p450 2c5 [48280] (1 species)

    • Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [48281] (3 PDB entries)

17. Mammalian cytochrome p450 2c8 [101377] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101378] (5 PDB entries)

18. Mammalian cytochrome p450 2c9 [89118] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89119] (4 PDB entries)
      Uniprot P11712

19. Mammalian cytochrome P450 3a4 [109958] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [109959] (7 PDB entries)
      Uniprot P08684

20. p450 monoxygenase OxyB [81863] (1 species)
    implicated in an oxidative phenol coupling reaction during vancomycin biosynthesis

    • Species Amycolatopsis orientalis [TaxId:31958] [81864] (3 PDB entries)

21. p450 monoxygenase OxyC [101371] (1 species)
    implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis

    • Species Amycolatopsis orientalis [TaxId:31958] [101372] (1 PDB entry)

22. Vitamin D 25-hydroxylase Cyp2R1 [158749] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [158750] (4 PDB entries)
      Uniprot Q6VVX0 39-501

23. automated matches [190068] (9 species)
    not a true protein

    1. Species Bacillus megaterium [TaxId:1348623] [323366] (4 PDB entries)

    2. Species Bacillus megaterium [TaxId:1404] [188479] (5 PDB entries)

    3. Species Bacillus subtilis [TaxId:1423] [189037] (2 PDB entries)

    4. Species Human (Homo sapiens) [TaxId:9606] [189507] (49 PDB entries)

    5. Species Mycobacterium tuberculosis [TaxId:1773] [187002] (1 PDB entry)

    6. Species Mycobacterium tuberculosis [TaxId:83332] [187210] (6 PDB entries)

    7. Species Pseudomonas putida [TaxId:303] [186787] (9 PDB entries)

    8. Species Streptomyces coelicolor [TaxId:100226] [187338] (8 PDB entries)

    9. Species Streptomyces coelicolor [TaxId:1902] [189873] (2 PDB entries)

More info for Family a.104.1.1: Cytochrome P450

Timeline for Family a.104.1.1: Cytochrome P450:

• Family a.104.1.1: Cytochrome P450 first appeared (with stable ids) in SCOP 1.55
  
• Family a.104.1.1: Cytochrome P450 appears in SCOPe 2.05
  
• Family a.104.1.1: Cytochrome P450 appears in SCOPe 2.07
  
• Family a.104.1.1: Cytochrome P450 appears in the current release, SCOPe 2.08