SCOP 1.71: Family a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain

Lineage for Family a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain

1. Root: SCOP 1.71

2. Class a: All alpha proteins [46456] (226 folds)

3. Fold a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
   multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

4. Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (10 families)
   N-terminal domain is Rossmann-fold with a family-specific C-terminal extension

5. Family a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain [48191] (2 proteins)

Proteins:

1. GDP-mannose 6-dehydrogenase, middle domain [89103] (1 species)
   forms segment-swapped dimer, unlike the homologous UDPGDH domain

   • Species Pseudomonas aeruginosa [TaxId:287] [89104] (3 PDB entries)

2. UDP-glucose dehydrogenase (UDPGDH), middle domain [48192] (1 species)

   • Species Streptococcus pyogenes [TaxId:1314] [48193] (2 PDB entries)

More info for Family a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain

Timeline for Family a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain:

• Family a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain first appeared (with stable ids) in SCOP 1.55, called Family a.100.1.4: UDP-glucose dehydrogenase (UDPGDH), middle domain
  
• Family a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain appears in SCOP 1.69
  
• Family a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain appears in SCOP 1.73
  
• Family a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain appears in the current release, SCOPe 2.08